High expression of CD47 predicts adverse prognosis in Chinese patients and suppresses immune response in melanoma

Cluster of differentiation 47 (CD47) negatively regulates macrophage phagocytosis and is correlated with adverse survival of multiple cancers. In melanoma patients, especially in Chinese melanoma patients, its prognostic value is unclear. In this study, we aim to study the prognostic value of CD47 i...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2017-09, Vol.93, p.1190-1196
Hauptverfasser:	Fu, Wenhua, Li, Jisen, Zhang, Wei, Li, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor - metabolism CD47 CD47 Antigen - metabolism Cell Differentiation - physiology Cell Line, Tumor Disease-Free Survival Female Humans Immune response Immunohistochemistry - methods Macrophages - metabolism Macrophages - pathology Male Melanoma Melanoma - metabolism Melanoma - pathology Mice Mice, Inbred C57BL Middle Aged Phagocytosis - physiology Prognosis Survival
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