Associations between gastric dilatation-volvulus in Great Danes and specific alleles of the canine immune-system genes DLA88, DRB1, and TLR5

OBJECTIVE To determine whether specific alleles of candidate genes of the major histocompatibility complex (MHC) and innate immune system were associated with gastric dilatation-volvulus (GDV) in Great Danes. ANIMALS 42 healthy Great Danes (control group) and 39 Great Danes with ≥ 1 GDV episode. PRO...

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Veröffentlicht in:	American journal of veterinary research 2017-08, Vol.78 (8), p.934-945
Hauptverfasser:	Harkey, Michael A, Villagran, Alexandra M, Venkataraman, Gopalakrishnan M, Leisenring, Wendy M, Hullar, Meredith A J, Torok-Storb, Beverly J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Autophagy-Related Proteins - genetics Dog Diseases - etiology Dog Diseases - genetics Dogs Female Gastric Dilatation - genetics Gastric Dilatation - veterinary Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class II - genetics Major Histocompatibility Complex - genetics Male Multivariate Analysis Nod2 Signaling Adaptor Protein - genetics Proportional Hazards Models Stomach Volvulus - genetics Stomach Volvulus - veterinary Toll-Like Receptor 5 - genetics
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