Validation of Dissolution Testing with Biorelevant Media: An OrBiTo Study

Dissolution testing with biorelevant media has become widespread in the pharmaceutical industry as a means of better understanding how drugs and formulations behave in the gastrointestinal tract. Until now, however, there have been few attempts to gauge the reproducibility of results obtained with t...

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Veröffentlicht in:	Molecular pharmaceutics 2017-12, Vol.14 (12), p.4192-4201
Hauptverfasser:	Mann, James, Dressman, Jennifer, Rosenblatt, Karin, Ashworth, Lee, Muenster, Uwe, Frank, Kerstin, Hutchins, Paul, Williams, James, Klumpp, Lukas, Wielockx, Kristina, Berben, Philippe, Augustijns, Patrick, Holm, Rene, Hofmann, Michael, Patel, Sanjaykumar, Beato, Stefania, Ojala, Krista, Tomaszewska, Irena, Bruel, Jean-Luc, Butler, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopharmaceutics - instrumentation Biopharmaceutics - methods Biopharmaceutics - standards Chemistry, Pharmaceutical - instrumentation Chemistry, Pharmaceutical - methods Chemistry, Pharmaceutical - standards Drug Liberation Hydrogen-Ion Concentration Ibuprofen - pharmacokinetics Intestine, Small - metabolism Reproducibility of Results Solubility Stomach - metabolism Tablets Tosyl Compounds - pharmacokinetics
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