A genome‐wide association study for equine recurrent airway obstruction in European Warmblood horses reveals a suggestive new quantitative trait locus on chromosome 13
Summary Recurrent airway obstruction (RAO), also known as heaves, is an asthma‐like respiratory disease. Its development is strongly influenced by environmental risk factors such as sensitization and exposure to moldy hay, straw bedding and stabling indoors. A hereditary component has been documente...
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| Veröffentlicht in: | Animal genetics 2017-12, Vol.48 (6), p.691-693 |
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| creator | Schnider, D. Rieder, S. Leeb, T. Gerber, V. Neuditschko, M. |
| description | Summary
Recurrent airway obstruction (RAO), also known as heaves, is an asthma‐like respiratory disease. Its development is strongly influenced by environmental risk factors such as sensitization and exposure to moldy hay, straw bedding and stabling indoors. A hereditary component has been documented in previous studies; however, so far no causative genetic variant that influences the risk of developing RAO has been identified. In this study, we revised an existing dataset and selected 384 horses for genotyping on the Affymetrix high‐density equine SNP array. We performed an allelic case–control genome‐wide association study, which revealed a suggestively significant association on equine chromosome 13 at 32 843 309 bp. This SNP is located in the protein‐coding gene TXNDC11, which is possibly involved in the folding process of the multiprotein complexes DUOX1 and DUOX2. In humans, these proteins are known to take part in regulating the production of H2O2 in the respiratory tract epithelium as well as in MUC5AC mucin expression. Therefore, TXNDC11 may be considered a functional candidate gene, and further research is needed to explore its potential role in RAO‐affected horses. |
| doi_str_mv | 10.1111/age.12583 |
| format | Article |
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Recurrent airway obstruction (RAO), also known as heaves, is an asthma‐like respiratory disease. Its development is strongly influenced by environmental risk factors such as sensitization and exposure to moldy hay, straw bedding and stabling indoors. A hereditary component has been documented in previous studies; however, so far no causative genetic variant that influences the risk of developing RAO has been identified. In this study, we revised an existing dataset and selected 384 horses for genotyping on the Affymetrix high‐density equine SNP array. We performed an allelic case–control genome‐wide association study, which revealed a suggestively significant association on equine chromosome 13 at 32 843 309 bp. This SNP is located in the protein‐coding gene TXNDC11, which is possibly involved in the folding process of the multiprotein complexes DUOX1 and DUOX2. In humans, these proteins are known to take part in regulating the production of H2O2 in the respiratory tract epithelium as well as in MUC5AC mucin expression. Therefore, TXNDC11 may be considered a functional candidate gene, and further research is needed to explore its potential role in RAO‐affected horses.</description><identifier>ISSN: 0268-9146</identifier><identifier>EISSN: 1365-2052</identifier><identifier>DOI: 10.1111/age.12583</identifier><identifier>PMID: 28737212</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Airway management ; Airway Obstruction - genetics ; Airway Obstruction - veterinary ; Animals ; Asthma ; Bedding ; Carrier Proteins - genetics ; Case-Control Studies ; Chromosome 13 ; Environmental risk ; Epithelium ; Gene expression ; Genetic Association Studies ; Genetic diversity ; Genetic variance ; genetics ; Genome-wide association studies ; Genomes ; genome‐wide association study ; Genotype ; Genotyping ; Horse Diseases - genetics ; Horses ; Horses - genetics ; Hydrogen peroxide ; Mucin ; multiprotein complexes DUOX1 and DUOX2 ; Polymorphism, Single Nucleotide ; Protein folding ; Proteins ; Quantitative Trait Loci ; Respiratory tract ; Risk analysis ; Risk factors ; Single-nucleotide polymorphism ; Straw ; TXNDC11 gene</subject><ispartof>Animal genetics, 2017-12, Vol.48 (6), p.691-693</ispartof><rights>2017 Stichting International Foundation for Animal Genetics</rights><rights>2017 Stichting International Foundation for Animal Genetics.</rights><rights>Copyright © 2017 Stichting International Foundation for Animal Genetics</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-f4fe15452d8d9ff47d4e7e481fa472c0748d25b1c1f80dd87394bb76b78d9d673</citedby><cites>FETCH-LOGICAL-c3533-f4fe15452d8d9ff47d4e7e481fa472c0748d25b1c1f80dd87394bb76b78d9d673</cites><orcidid>0000-0003-0553-4880 ; 0000-0002-4658-2187</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fage.12583$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fage.12583$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28737212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schnider, D.</creatorcontrib><creatorcontrib>Rieder, S.</creatorcontrib><creatorcontrib>Leeb, T.</creatorcontrib><creatorcontrib>Gerber, V.</creatorcontrib><creatorcontrib>Neuditschko, M.</creatorcontrib><title>A genome‐wide association study for equine recurrent airway obstruction in European Warmblood horses reveals a suggestive new quantitative trait locus on chromosome 13</title><title>Animal genetics</title><addtitle>Anim Genet</addtitle><description>Summary
Recurrent airway obstruction (RAO), also known as heaves, is an asthma‐like respiratory disease. Its development is strongly influenced by environmental risk factors such as sensitization and exposure to moldy hay, straw bedding and stabling indoors. A hereditary component has been documented in previous studies; however, so far no causative genetic variant that influences the risk of developing RAO has been identified. In this study, we revised an existing dataset and selected 384 horses for genotyping on the Affymetrix high‐density equine SNP array. We performed an allelic case–control genome‐wide association study, which revealed a suggestively significant association on equine chromosome 13 at 32 843 309 bp. This SNP is located in the protein‐coding gene TXNDC11, which is possibly involved in the folding process of the multiprotein complexes DUOX1 and DUOX2. In humans, these proteins are known to take part in regulating the production of H2O2 in the respiratory tract epithelium as well as in MUC5AC mucin expression. Therefore, TXNDC11 may be considered a functional candidate gene, and further research is needed to explore its potential role in RAO‐affected horses.</description><subject>Airway management</subject><subject>Airway Obstruction - genetics</subject><subject>Airway Obstruction - veterinary</subject><subject>Animals</subject><subject>Asthma</subject><subject>Bedding</subject><subject>Carrier Proteins - genetics</subject><subject>Case-Control Studies</subject><subject>Chromosome 13</subject><subject>Environmental risk</subject><subject>Epithelium</subject><subject>Gene expression</subject><subject>Genetic Association Studies</subject><subject>Genetic diversity</subject><subject>Genetic variance</subject><subject>genetics</subject><subject>Genome-wide association studies</subject><subject>Genomes</subject><subject>genome‐wide association study</subject><subject>Genotype</subject><subject>Genotyping</subject><subject>Horse Diseases - genetics</subject><subject>Horses</subject><subject>Horses - genetics</subject><subject>Hydrogen peroxide</subject><subject>Mucin</subject><subject>multiprotein complexes DUOX1 and DUOX2</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Protein folding</subject><subject>Proteins</subject><subject>Quantitative Trait Loci</subject><subject>Respiratory tract</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Single-nucleotide polymorphism</subject><subject>Straw</subject><subject>TXNDC11 gene</subject><issn>0268-9146</issn><issn>1365-2052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAURi1ERYfCghdAltjAIq3_EjvLUTUtSJW6AbGMHPtm6iqxZ-y4o9n1EXiNvhZPgpkpLJC4G0tXx0ef7ofQO0rOaZkLvYZzymrFX6AF5U1dMVKzl2hBWKOqlormFL1O6Z4Qoqikr9ApU5JLRtkCPS3xGnyY4Ofjj52zgHVKwTg9u-BxmrPd4yFEDNvsPOAIJscIfsbaxZ3e49CnOWZzoJ3HqxzDBrTH33Wc-jEEi-9CTJDKzwfQY8Iap7xeQ5rdA2APO7zN2s9u1ofFHLWb8RhMTrgYzV0MU0glHab8DToZigHePr9n6NvV6uvl5-rm9vrL5fKmMrzmvBrEALQWNbPKtsMgpBUgQSg6aCGZIVIoy-qeGjooYm05RCv6Xja9LLxtJD9DH4_eTQzbXJJ2k0sGxlF7CDl1tGWckpbTpqAf_kHvQ46-pCtUw1WjKBWF-nSkTAwpRRi6TXSTjvuOku53f13przv0V9j3z8bcT2D_kn8KK8DFEdi5Efb_N3XL69VR-QtDaai5</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Schnider, D.</creator><creator>Rieder, S.</creator><creator>Leeb, T.</creator><creator>Gerber, V.</creator><creator>Neuditschko, M.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0553-4880</orcidid><orcidid>https://orcid.org/0000-0002-4658-2187</orcidid></search><sort><creationdate>201712</creationdate><title>A genome‐wide association study for equine recurrent airway obstruction in European Warmblood horses reveals a suggestive new quantitative trait locus on chromosome 13</title><author>Schnider, D. ; Rieder, S. ; Leeb, T. ; Gerber, V. ; Neuditschko, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-f4fe15452d8d9ff47d4e7e481fa472c0748d25b1c1f80dd87394bb76b78d9d673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Airway management</topic><topic>Airway Obstruction - genetics</topic><topic>Airway Obstruction - veterinary</topic><topic>Animals</topic><topic>Asthma</topic><topic>Bedding</topic><topic>Carrier Proteins - genetics</topic><topic>Case-Control Studies</topic><topic>Chromosome 13</topic><topic>Environmental risk</topic><topic>Epithelium</topic><topic>Gene expression</topic><topic>Genetic Association Studies</topic><topic>Genetic diversity</topic><topic>Genetic variance</topic><topic>genetics</topic><topic>Genome-wide association studies</topic><topic>Genomes</topic><topic>genome‐wide association study</topic><topic>Genotype</topic><topic>Genotyping</topic><topic>Horse Diseases - genetics</topic><topic>Horses</topic><topic>Horses - genetics</topic><topic>Hydrogen peroxide</topic><topic>Mucin</topic><topic>multiprotein complexes DUOX1 and DUOX2</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Protein folding</topic><topic>Proteins</topic><topic>Quantitative Trait Loci</topic><topic>Respiratory tract</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Single-nucleotide polymorphism</topic><topic>Straw</topic><topic>TXNDC11 gene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schnider, D.</creatorcontrib><creatorcontrib>Rieder, S.</creatorcontrib><creatorcontrib>Leeb, T.</creatorcontrib><creatorcontrib>Gerber, V.</creatorcontrib><creatorcontrib>Neuditschko, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Animal genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schnider, D.</au><au>Rieder, S.</au><au>Leeb, T.</au><au>Gerber, V.</au><au>Neuditschko, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A genome‐wide association study for equine recurrent airway obstruction in European Warmblood horses reveals a suggestive new quantitative trait locus on chromosome 13</atitle><jtitle>Animal genetics</jtitle><addtitle>Anim Genet</addtitle><date>2017-12</date><risdate>2017</risdate><volume>48</volume><issue>6</issue><spage>691</spage><epage>693</epage><pages>691-693</pages><issn>0268-9146</issn><eissn>1365-2052</eissn><abstract>Summary
Recurrent airway obstruction (RAO), also known as heaves, is an asthma‐like respiratory disease. Its development is strongly influenced by environmental risk factors such as sensitization and exposure to moldy hay, straw bedding and stabling indoors. A hereditary component has been documented in previous studies; however, so far no causative genetic variant that influences the risk of developing RAO has been identified. In this study, we revised an existing dataset and selected 384 horses for genotyping on the Affymetrix high‐density equine SNP array. We performed an allelic case–control genome‐wide association study, which revealed a suggestively significant association on equine chromosome 13 at 32 843 309 bp. This SNP is located in the protein‐coding gene TXNDC11, which is possibly involved in the folding process of the multiprotein complexes DUOX1 and DUOX2. In humans, these proteins are known to take part in regulating the production of H2O2 in the respiratory tract epithelium as well as in MUC5AC mucin expression. Therefore, TXNDC11 may be considered a functional candidate gene, and further research is needed to explore its potential role in RAO‐affected horses.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28737212</pmid><doi>10.1111/age.12583</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0003-0553-4880</orcidid><orcidid>https://orcid.org/0000-0002-4658-2187</orcidid></addata></record> |
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| ispartof | Animal genetics, 2017-12, Vol.48 (6), p.691-693 |
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| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Airway management Airway Obstruction - genetics Airway Obstruction - veterinary Animals Asthma Bedding Carrier Proteins - genetics Case-Control Studies Chromosome 13 Environmental risk Epithelium Gene expression Genetic Association Studies Genetic diversity Genetic variance genetics Genome-wide association studies Genomes genome‐wide association study Genotype Genotyping Horse Diseases - genetics Horses Horses - genetics Hydrogen peroxide Mucin multiprotein complexes DUOX1 and DUOX2 Polymorphism, Single Nucleotide Protein folding Proteins Quantitative Trait Loci Respiratory tract Risk analysis Risk factors Single-nucleotide polymorphism Straw TXNDC11 gene |
| title | A genome‐wide association study for equine recurrent airway obstruction in European Warmblood horses reveals a suggestive new quantitative trait locus on chromosome 13 |
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