Asymmetric Synthesis of α,α‐Disubstituted Allylic Amines through Palladium‐Catalyzed Allylic Substitution

The first asymmetric synthesis of important α,α‐disubstituted N‐alkyl allyl amine scaffolds through allylic substitution is reported. This approach is based on palladium catalysis and features ample scope with respect to both the allylic precursor and amine reagent, and high asymmetric induction wit...

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Veröffentlicht in:	Angewandte Chemie International Edition 2017-09, Vol.56 (39), p.11797-11801
Hauptverfasser:	Guo, Wusheng, Cai, Aijie, Xie, Jianing, Kleij, Arjan W.
Format:	Artikel
Sprache:	eng
Schlagworte:	allylic amines allylic substitution enantioselectivity palladium regioselectivity
Online-Zugang:	Volltext
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