Antitumor efficacy of Venezuelan equine encephalitis virus replicon particles encoding mutated HPV16 E6 and E7 genes

An effective vaccine for treating human papillomavirus (HPV)-associated malignancies such as cervical cancer should elicit strong T cell-mediated immunity (CMI) against the E6 and/or E7 proteins necessary for the malignant state. We have developed Venezuelan equine encephalitis (VEE) virus replicon...

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Veröffentlicht in:	Vaccine 2004-01, Vol.22 (3), p.520-527
Hauptverfasser:	Cassetti, M.Cristina, McElhiney, Sue P., Shahabi, Vafa, Pullen, Jeffrey K., Le Poole, I.Caroline, Eiben, Gretchen L., Smith, Larry R., Kast, W.Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	AE6 gene AE7 gene Alphavirus Animals Antineoplastic agents Biological and medical sciences Cell Survival - drug effects CTL E6 gene E7 gene Encephalitis Virus, Venezuelan Equine - immunology Female Fundamental and applied biological sciences. Psychology Genes, p53 - genetics Genes, Viral - immunology histocompatibility antigen HLA Human papillomavirus Human papillomavirus 16 Immunization Immunotherapy Medical sciences Mice Mice, Inbred C57BL Microbiology Mutagenesis - genetics Neoplasm Transplantation Oncogene Proteins, Viral - genetics Oncogene Proteins, Viral - immunology Papilloma - prevention & control Papilloma - virology Papillomaviridae - immunology Papillomavirus E7 Proteins Pharmacology. Drug treatments Phenotype Replicon - immunology Repressor Proteins Tumor therapy Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Venezuelan equine encephalitis virus Virology
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