Comprehensive Model for Allosteric Regulation of Mammalian Ribonucleotide Reductase: Refinements and Consequences

Reduction of NDPs by murine ribonucleotide reductase (mRR) requires catalytic (mR1) and free radical-containing (mR2) subunits and is regulated by nucleoside triphosphate allosteric effectors. Here we present the results of several studies that refine the recently presented comprehensive model for t...

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Veröffentlicht in:	Biochemistry (Easton) 2003-02, Vol.42 (6), p.1696-1706
Hauptverfasser:	Kashlan, Ossama B, Cooperman, Barry S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - chemistry Allosteric Regulation - genetics Animals Asparagine - genetics Aspartic Acid - genetics Cytidine Diphosphate - chemistry Deoxyadenine Nucleotides - chemistry Dimerization Enzyme Activation - genetics Guanosine Diphosphate - chemistry Kinetics Light Magnesium - chemistry Mice Models, Chemical Mutagenesis, Site-Directed Protein Subunits - antagonists & inhibitors Protein Subunits - chemistry Protein Subunits - genetics Recombinant Proteins - antagonists & inhibitors Recombinant Proteins - chemistry Recombinant Proteins - genetics Ribonucleotide Reductases - antagonists & inhibitors Ribonucleotide Reductases - chemistry Ribonucleotide Reductases - genetics Scattering, Radiation Substrate Specificity - genetics Thymine Nucleotides - chemistry Tumor Cells, Cultured
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