Liver toxicities typically induced by first-generation adenoviral vectors can be reduced by use of E1, E2b-deleted adenoviral vectors

Adenoviral vectors from which the E1 region has been deleted ([E1(-)] Ad) are known to induce strong immune responses after systemic delivery. In this study we have evaluated liver toxicities in mice after intravenous injection with high doses of [E1(-)] or modified [E1(-), E2b(-)] Ad vectors (both...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human gene therapy 2003-12, Vol.14 (18), p.1715-1726
Hauptverfasser:	EVERETT, R. S, HODGES, B. L, DING, E. Y, XU, F, SERRA, D, AMALFITANO, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - pathogenicity Adenovirus Adenovirus E1 Proteins - genetics Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Disease Models, Animal Fundamental and applied biological sciences. Psychology Gene therapy Gene Transfer Techniques Genetic Therapy - adverse effects Genetic Vectors Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Lac Operon - genetics Liver - pathology Liver - virology Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, SCID Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!