Association of clinical and serological parameters of systemic lupus erythematosus patients with Epstein‐Barr virus antibody profile
Epstein‐Barr viral infection is one of the known environmental factors involved in development of Systemic Lupus Erythematous (SLE). Though not much is known about the exact role of Epstein‐Barr virus (EBV) in SLE pathogenesis, the theory of switching of lytic and lysogenic cycles of EBV in memory B...
Gespeichert in:
| Veröffentlicht in: | Journal of medical virology 2018-03, Vol.90 (3), p.559-563 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 563 |
|---|---|
| container_issue | 3 |
| container_start_page | 559 |
| container_title | Journal of medical virology |
| container_volume | 90 |
| creator | Chougule, Durga Nadkar, Milind Rajadhyaksha, Anjali Pandit‐Shende, Pallavi Surve, Prathamesh Dawkar, Nausheen Khadilkar, Prasad Patwardhan, Manisha Kaveri, Srini Ghosh, Kanjaksha Pradhan, Vandana |
| description | Epstein‐Barr viral infection is one of the known environmental factors involved in development of Systemic Lupus Erythematous (SLE). Though not much is known about the exact role of Epstein‐Barr virus (EBV) in SLE pathogenesis, the theory of switching of lytic and lysogenic cycles of EBV in memory B cells fits well with the periods of waning disease activity and intermittent flares in SLE patients. In this study, we investigate the association of EBV antibody profile with clinical and serological parameters in SLE. Eighty‐seven clinically diagnosed SLE patients fulfilling the American College of Rheumatology (ACR) classification criteria and fifty healthy individuals were enrolled in this case control study. Anti‐VCA IgM, anti‐VCA IgG, and anti‐EBNA IgG were detected by ELISA technique. Antibodies concentrations between two groups were compared using Mann‐Whitney whereas the difference in categorical data was compared using Chi‐square considering statistical significance at P |
| doi_str_mv | 10.1002/jmv.24904 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1922509552</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1985662682</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3534-867915b93a5977bfb62571df6bcc355fd826de48c7e6df1b70090414fef61a603</originalsourceid><addsrcrecordid>eNp10bFu1TAUBmALgeilMPACyBILDGltJ7aTsVSFglqxAGvkOMfUV0kcfJxW2ZiYeUaepL69hQGpk3WkT_-xzk_IS86OOGPieDteH4mqYdUjsuGsUUXDNH9MNoxXqlCKywPyDHHLGKsbIZ6SA1HrsmK62pBfJ4jBepN8mGhw1A5-8tYM1Ew9RYhhCN_v5tlEM0KCiDuGKyYYvaXDMi9IIa7pCkaTAuZpzmkwJaQ3Pl3RszlTP_35-fudiZFe-5iJmZLvQr_SOQbnB3hOnjgzILy4fw_J1_dnX07Pi4vPHz6enlwUtpRlVdRKN1x2TWlko3XnOiWk5r1Tnc1Aur4WqoeqthpU73inGctX4ZUDp7hRrDwkb_a5ee-PBTC1o0cLw2AmCAu2PN9HskZKkenr_-g2LHHKv8uqlkoJVe_U272yMSBGcO0c_Wji2nLW7sppczntXTnZvrpPXLoR-n_ybxsZHO_BTT7J-nBS--ny2z7yFuZmnHM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1985662682</pqid></control><display><type>article</type><title>Association of clinical and serological parameters of systemic lupus erythematosus patients with Epstein‐Barr virus antibody profile</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Chougule, Durga ; Nadkar, Milind ; Rajadhyaksha, Anjali ; Pandit‐Shende, Pallavi ; Surve, Prathamesh ; Dawkar, Nausheen ; Khadilkar, Prasad ; Patwardhan, Manisha ; Kaveri, Srini ; Ghosh, Kanjaksha ; Pradhan, Vandana</creator><creatorcontrib>Chougule, Durga ; Nadkar, Milind ; Rajadhyaksha, Anjali ; Pandit‐Shende, Pallavi ; Surve, Prathamesh ; Dawkar, Nausheen ; Khadilkar, Prasad ; Patwardhan, Manisha ; Kaveri, Srini ; Ghosh, Kanjaksha ; Pradhan, Vandana</creatorcontrib><description>Epstein‐Barr viral infection is one of the known environmental factors involved in development of Systemic Lupus Erythematous (SLE). Though not much is known about the exact role of Epstein‐Barr virus (EBV) in SLE pathogenesis, the theory of switching of lytic and lysogenic cycles of EBV in memory B cells fits well with the periods of waning disease activity and intermittent flares in SLE patients. In this study, we investigate the association of EBV antibody profile with clinical and serological parameters in SLE. Eighty‐seven clinically diagnosed SLE patients fulfilling the American College of Rheumatology (ACR) classification criteria and fifty healthy individuals were enrolled in this case control study. Anti‐VCA IgM, anti‐VCA IgG, and anti‐EBNA IgG were detected by ELISA technique. Antibodies concentrations between two groups were compared using Mann‐Whitney whereas the difference in categorical data was compared using Chi‐square considering statistical significance at P < 0.05. This study demonstrated a significant increase in EBV VCA‐IgG, VCA‐IgM, and EBNA‐IgG antibodies levels of SLE patients when compared to healthy controls (P < 0.05). High seroprevalence was seen in both the study groups for EBV VCA‐IgG and EBNA‐IgG antibodies when compared to VCA‐IgM antibodies. A significant increase was noted in the anti‐VCA‐IgG levels with dsDNA autoantibody positivity (P < 0.05). Though there was no significant association between EBV antibody profile and clinical manifestations, 100% seropositivity for anti‐VCA‐IgG was seen in SLE patients with renal manifestations. Association of anti‐VCA IgG levels with presence of anti‐dsDNA antibodies suggests a possible role of EBV as an environmental trigger in pathogenesis of SLE.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.24904</identifier><identifier>PMID: 28734074</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Anti-DNA antibodies ; Antibodies ; Autoantibodies ; Autoimmune diseases ; autoimmunity molecular mimicry ; Chronic conditions ; EBV antibodies ; Environmental factors ; Enzyme-linked immunosorbent assay ; Epstein-Barr virus ; Epstein‐Barr virus (EBV) ; Health risk assessment ; Immunoglobulin G ; Immunoglobulin M ; Immunoglobulins ; Immunological memory ; Kidneys ; Lupus ; Lymphocytes B ; Memory cells ; Pathogenesis ; Patients ; Serology ; Statistical tests ; Systemic lupus erythematosus ; systemic lupus erythematosus (SLE) ; Virology ; Viruses</subject><ispartof>Journal of medical virology, 2018-03, Vol.90 (3), p.559-563</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3534-867915b93a5977bfb62571df6bcc355fd826de48c7e6df1b70090414fef61a603</citedby><orcidid>0000-0003-2717-3123</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.24904$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.24904$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28734074$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chougule, Durga</creatorcontrib><creatorcontrib>Nadkar, Milind</creatorcontrib><creatorcontrib>Rajadhyaksha, Anjali</creatorcontrib><creatorcontrib>Pandit‐Shende, Pallavi</creatorcontrib><creatorcontrib>Surve, Prathamesh</creatorcontrib><creatorcontrib>Dawkar, Nausheen</creatorcontrib><creatorcontrib>Khadilkar, Prasad</creatorcontrib><creatorcontrib>Patwardhan, Manisha</creatorcontrib><creatorcontrib>Kaveri, Srini</creatorcontrib><creatorcontrib>Ghosh, Kanjaksha</creatorcontrib><creatorcontrib>Pradhan, Vandana</creatorcontrib><title>Association of clinical and serological parameters of systemic lupus erythematosus patients with Epstein‐Barr virus antibody profile</title><title>Journal of medical virology</title><addtitle>J Med Virol</addtitle><description>Epstein‐Barr viral infection is one of the known environmental factors involved in development of Systemic Lupus Erythematous (SLE). Though not much is known about the exact role of Epstein‐Barr virus (EBV) in SLE pathogenesis, the theory of switching of lytic and lysogenic cycles of EBV in memory B cells fits well with the periods of waning disease activity and intermittent flares in SLE patients. In this study, we investigate the association of EBV antibody profile with clinical and serological parameters in SLE. Eighty‐seven clinically diagnosed SLE patients fulfilling the American College of Rheumatology (ACR) classification criteria and fifty healthy individuals were enrolled in this case control study. Anti‐VCA IgM, anti‐VCA IgG, and anti‐EBNA IgG were detected by ELISA technique. Antibodies concentrations between two groups were compared using Mann‐Whitney whereas the difference in categorical data was compared using Chi‐square considering statistical significance at P < 0.05. This study demonstrated a significant increase in EBV VCA‐IgG, VCA‐IgM, and EBNA‐IgG antibodies levels of SLE patients when compared to healthy controls (P < 0.05). High seroprevalence was seen in both the study groups for EBV VCA‐IgG and EBNA‐IgG antibodies when compared to VCA‐IgM antibodies. A significant increase was noted in the anti‐VCA‐IgG levels with dsDNA autoantibody positivity (P < 0.05). Though there was no significant association between EBV antibody profile and clinical manifestations, 100% seropositivity for anti‐VCA‐IgG was seen in SLE patients with renal manifestations. Association of anti‐VCA IgG levels with presence of anti‐dsDNA antibodies suggests a possible role of EBV as an environmental trigger in pathogenesis of SLE.</description><subject>Anti-DNA antibodies</subject><subject>Antibodies</subject><subject>Autoantibodies</subject><subject>Autoimmune diseases</subject><subject>autoimmunity molecular mimicry</subject><subject>Chronic conditions</subject><subject>EBV antibodies</subject><subject>Environmental factors</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Epstein-Barr virus</subject><subject>Epstein‐Barr virus (EBV)</subject><subject>Health risk assessment</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin M</subject><subject>Immunoglobulins</subject><subject>Immunological memory</subject><subject>Kidneys</subject><subject>Lupus</subject><subject>Lymphocytes B</subject><subject>Memory cells</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Serology</subject><subject>Statistical tests</subject><subject>Systemic lupus erythematosus</subject><subject>systemic lupus erythematosus (SLE)</subject><subject>Virology</subject><subject>Viruses</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp10bFu1TAUBmALgeilMPACyBILDGltJ7aTsVSFglqxAGvkOMfUV0kcfJxW2ZiYeUaepL69hQGpk3WkT_-xzk_IS86OOGPieDteH4mqYdUjsuGsUUXDNH9MNoxXqlCKywPyDHHLGKsbIZ6SA1HrsmK62pBfJ4jBepN8mGhw1A5-8tYM1Ew9RYhhCN_v5tlEM0KCiDuGKyYYvaXDMi9IIa7pCkaTAuZpzmkwJaQ3Pl3RszlTP_35-fudiZFe-5iJmZLvQr_SOQbnB3hOnjgzILy4fw_J1_dnX07Pi4vPHz6enlwUtpRlVdRKN1x2TWlko3XnOiWk5r1Tnc1Aur4WqoeqthpU73inGctX4ZUDp7hRrDwkb_a5ee-PBTC1o0cLw2AmCAu2PN9HskZKkenr_-g2LHHKv8uqlkoJVe_U272yMSBGcO0c_Wji2nLW7sppczntXTnZvrpPXLoR-n_ybxsZHO_BTT7J-nBS--ny2z7yFuZmnHM</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Chougule, Durga</creator><creator>Nadkar, Milind</creator><creator>Rajadhyaksha, Anjali</creator><creator>Pandit‐Shende, Pallavi</creator><creator>Surve, Prathamesh</creator><creator>Dawkar, Nausheen</creator><creator>Khadilkar, Prasad</creator><creator>Patwardhan, Manisha</creator><creator>Kaveri, Srini</creator><creator>Ghosh, Kanjaksha</creator><creator>Pradhan, Vandana</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2717-3123</orcidid></search><sort><creationdate>201803</creationdate><title>Association of clinical and serological parameters of systemic lupus erythematosus patients with Epstein‐Barr virus antibody profile</title><author>Chougule, Durga ; Nadkar, Milind ; Rajadhyaksha, Anjali ; Pandit‐Shende, Pallavi ; Surve, Prathamesh ; Dawkar, Nausheen ; Khadilkar, Prasad ; Patwardhan, Manisha ; Kaveri, Srini ; Ghosh, Kanjaksha ; Pradhan, Vandana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3534-867915b93a5977bfb62571df6bcc355fd826de48c7e6df1b70090414fef61a603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anti-DNA antibodies</topic><topic>Antibodies</topic><topic>Autoantibodies</topic><topic>Autoimmune diseases</topic><topic>autoimmunity molecular mimicry</topic><topic>Chronic conditions</topic><topic>EBV antibodies</topic><topic>Environmental factors</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Epstein-Barr virus</topic><topic>Epstein‐Barr virus (EBV)</topic><topic>Health risk assessment</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin M</topic><topic>Immunoglobulins</topic><topic>Immunological memory</topic><topic>Kidneys</topic><topic>Lupus</topic><topic>Lymphocytes B</topic><topic>Memory cells</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Serology</topic><topic>Statistical tests</topic><topic>Systemic lupus erythematosus</topic><topic>systemic lupus erythematosus (SLE)</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chougule, Durga</creatorcontrib><creatorcontrib>Nadkar, Milind</creatorcontrib><creatorcontrib>Rajadhyaksha, Anjali</creatorcontrib><creatorcontrib>Pandit‐Shende, Pallavi</creatorcontrib><creatorcontrib>Surve, Prathamesh</creatorcontrib><creatorcontrib>Dawkar, Nausheen</creatorcontrib><creatorcontrib>Khadilkar, Prasad</creatorcontrib><creatorcontrib>Patwardhan, Manisha</creatorcontrib><creatorcontrib>Kaveri, Srini</creatorcontrib><creatorcontrib>Ghosh, Kanjaksha</creatorcontrib><creatorcontrib>Pradhan, Vandana</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chougule, Durga</au><au>Nadkar, Milind</au><au>Rajadhyaksha, Anjali</au><au>Pandit‐Shende, Pallavi</au><au>Surve, Prathamesh</au><au>Dawkar, Nausheen</au><au>Khadilkar, Prasad</au><au>Patwardhan, Manisha</au><au>Kaveri, Srini</au><au>Ghosh, Kanjaksha</au><au>Pradhan, Vandana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of clinical and serological parameters of systemic lupus erythematosus patients with Epstein‐Barr virus antibody profile</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J Med Virol</addtitle><date>2018-03</date><risdate>2018</risdate><volume>90</volume><issue>3</issue><spage>559</spage><epage>563</epage><pages>559-563</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>Epstein‐Barr viral infection is one of the known environmental factors involved in development of Systemic Lupus Erythematous (SLE). Though not much is known about the exact role of Epstein‐Barr virus (EBV) in SLE pathogenesis, the theory of switching of lytic and lysogenic cycles of EBV in memory B cells fits well with the periods of waning disease activity and intermittent flares in SLE patients. In this study, we investigate the association of EBV antibody profile with clinical and serological parameters in SLE. Eighty‐seven clinically diagnosed SLE patients fulfilling the American College of Rheumatology (ACR) classification criteria and fifty healthy individuals were enrolled in this case control study. Anti‐VCA IgM, anti‐VCA IgG, and anti‐EBNA IgG were detected by ELISA technique. Antibodies concentrations between two groups were compared using Mann‐Whitney whereas the difference in categorical data was compared using Chi‐square considering statistical significance at P < 0.05. This study demonstrated a significant increase in EBV VCA‐IgG, VCA‐IgM, and EBNA‐IgG antibodies levels of SLE patients when compared to healthy controls (P < 0.05). High seroprevalence was seen in both the study groups for EBV VCA‐IgG and EBNA‐IgG antibodies when compared to VCA‐IgM antibodies. A significant increase was noted in the anti‐VCA‐IgG levels with dsDNA autoantibody positivity (P < 0.05). Though there was no significant association between EBV antibody profile and clinical manifestations, 100% seropositivity for anti‐VCA‐IgG was seen in SLE patients with renal manifestations. Association of anti‐VCA IgG levels with presence of anti‐dsDNA antibodies suggests a possible role of EBV as an environmental trigger in pathogenesis of SLE.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28734074</pmid><doi>10.1002/jmv.24904</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-2717-3123</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0146-6615 |
| ispartof | Journal of medical virology, 2018-03, Vol.90 (3), p.559-563 |
| issn | 0146-6615 1096-9071 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1922509552 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Anti-DNA antibodies Antibodies Autoantibodies Autoimmune diseases autoimmunity molecular mimicry Chronic conditions EBV antibodies Environmental factors Enzyme-linked immunosorbent assay Epstein-Barr virus Epstein‐Barr virus (EBV) Health risk assessment Immunoglobulin G Immunoglobulin M Immunoglobulins Immunological memory Kidneys Lupus Lymphocytes B Memory cells Pathogenesis Patients Serology Statistical tests Systemic lupus erythematosus systemic lupus erythematosus (SLE) Virology Viruses |
| title | Association of clinical and serological parameters of systemic lupus erythematosus patients with Epstein‐Barr virus antibody profile |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T00%3A50%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20clinical%20and%20serological%20parameters%20of%20systemic%20lupus%20erythematosus%20patients%20with%20Epstein%E2%80%90Barr%20virus%20antibody%20profile&rft.jtitle=Journal%20of%20medical%20virology&rft.au=Chougule,%20Durga&rft.date=2018-03&rft.volume=90&rft.issue=3&rft.spage=559&rft.epage=563&rft.pages=559-563&rft.issn=0146-6615&rft.eissn=1096-9071&rft_id=info:doi/10.1002/jmv.24904&rft_dat=%3Cproquest_cross%3E1985662682%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1985662682&rft_id=info:pmid/28734074&rfr_iscdi=true |