Determination of the Relationship between Expression and Functional Activity of Multidrug Resistance-Associated Protein 1 using Scanning Electrochemical Microscopy

Cancer cells can develop multidrug resistance (MDR) after prolonged exposure to chemotherapeutic drugs, which is a severe impediment to successful treatment. MDR is typically associated with transmembrane proteins mediating efflux of administered drugs, thereby keeping their intracellular concentrat...

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Veröffentlicht in:	Analytical chemistry (Washington) 2017-09, Vol.89 (17), p.8988-8994
Hauptverfasser:	Polcari, David, Hernández-Castro, Javier Alejandro, Li, Kebin, Geissler, Matthias, Mauzeroll, Janine
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Cell adhesion Cells Chemistry Chemotherapy Cytometry Doxorubicin Efflux Electrochemistry Flow cytometry Light microscopy Membrane proteins Multidrug resistance Multidrug resistant organisms Optical microscopy Plastics Proteins Scanning Substrates Windows (intervals)
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