Selective induction of DNA damage, G2 abrogation, and mitochondrial apoptosis by leaf extract of traditional medicinal plant Wrightia arborea in K562 cells

Plants have proved to be an important source of anti-cancer drugs. Wrightia arborea , an Indian Ayurvedic medicinal plant, is used traditionally to treat a variety of ailments. This study evaluates the antiproliferative/apoptotic potential of Wrightia arborea leaf extracts, prepared in different org...

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Veröffentlicht in:	Protoplasma 2018, Vol.255 (1), p.203-216
Hauptverfasser:	Lakshmipriya, T., Soumya, T., Jayasree, P. R., Manish Kumar, P. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biomedical and Life Sciences Calcium Camptothecin Cancer Caspase-3 Cell Biology Cell cycle Cell death CHK1 protein Chloroform Comet assay Deoxyribonucleic acid Depolarization DNA DNA damage DNA fragmentation Flow cytometry Herbal medicine Leaves Leukemia Life Sciences Lymphocytes Medicinal plants Membrane potential Original Article Plant Sciences Poly(ADP-ribose) polymerase Tumor cell lines Western blotting Wrightia arborea Zoology
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