Solanum paniculatum L. decreases levels of inflammatory cytokines by reducing NFKB, TBET and GATA3 gene expression in vitro
Solanum paniculatum L., popularly known as jurubeba, is a common subtropical plant from Brazil, Paraguay, Bolivia and Argentina, that is used in folk medicine for the treatment of anemia, gastrointestinal disorders and inflammatory conditions in general. In addition to that, an ethnobotanical survey...
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| Veröffentlicht in: | Journal of ethnopharmacology 2017-09, Vol.209, p.32-40 |
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| creator | Rios, Raimon Silva, Hugo Bernardino Ferreira da Carneiro, Norma Vilany Queiroz Pires, Anaque de Oliveira Carneiro, Tamires Cana Brasil Costa, Ryan dos Santos Marques, Cintia Rodrigues Machado, Marta Santos Serafim Velozo, Eudes da Silva Silva, Telma M.G. da Silva, Tania M.S. da Conceição, Adilva de Souza Alcântara-Neves, Neuza Maria Figueiredo, Camila Alexandrina |
| description | Solanum paniculatum L., popularly known as jurubeba, is a common subtropical plant from Brazil, Paraguay, Bolivia and Argentina, that is used in folk medicine for the treatment of anemia, gastrointestinal disorders and inflammatory conditions in general. In addition to that, an ethnobotanical survey in “Todos os Santos” Bay have pointed out S. paniculatum as an herb to treat asthma. Previous publications have shown that S. paniculatum possesses antibiotic, antioxidant and modulatory effects on gastric acid secretion; however, its anti-inflammatory potential remains unexplored.
Herein, we analyzed the S. paniculatum fruits hexane extract (SpE) for the presence of stigmasterol and β-sitosterol and investigated the anti-inflammatory effect of SpE in vitro.
SpE was subjected to high-performance liquid chromatography (HPLC) for standardization and quantification of stigmasterol and β-sitosterol. Spleen cells from BALB/c mice were cultivated and stimulated with pokeweed mitogen and also exposed to 15, 30 and 60µg/mL of SpE. Following treatment, levels of IFN-γ, IL-4 and IL-10 in the culture supernatants were assessed by ELISA. We also evaluated nitric oxide (NO) production by murine LPS-stimulated peritoneal macrophages using the Griess technique. In addition, the ability of SpE to stabilize membranes was assessed using a model of hemolysis induced by heat on murine erythrocytes. Gene expression of Th1-cell-specific Tbx21 transcription factor (TBET), zinc-finger transcription factor-3 (GATA3), and nuclear factor-κB (NFKB) in murine spleen cells were assessed by quantitative Polymerase Chain Reaction (qRT-PCR).
SpE at 15, 30 and 60µg/mL significantly attenuated cell proliferation, decreased IL-4 release, reduced NO production and improved erythrocyte membrane stabilization in a concentration-dependent manner. SpE was also able to decrease the release of IFN-γ without altering IL-10 levels. The mechanism whereby SpE decreased inflammatory markers may be related to the reduction of NFKB, TBET and GATA3 gene expression.
This study is the first to test the anti-inflammatory action of S. paniculatum. Herein, we provided evidence for the popular use of S. paniculatum in inflammatory conditions. Additional studies must be conducted to further explore the anti-inflammatory potential of SpE and to elucidate possible clinical applications.
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| doi_str_mv | 10.1016/j.jep.2017.07.014 |
| format | Article |
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Herein, we analyzed the S. paniculatum fruits hexane extract (SpE) for the presence of stigmasterol and β-sitosterol and investigated the anti-inflammatory effect of SpE in vitro.
SpE was subjected to high-performance liquid chromatography (HPLC) for standardization and quantification of stigmasterol and β-sitosterol. Spleen cells from BALB/c mice were cultivated and stimulated with pokeweed mitogen and also exposed to 15, 30 and 60µg/mL of SpE. Following treatment, levels of IFN-γ, IL-4 and IL-10 in the culture supernatants were assessed by ELISA. We also evaluated nitric oxide (NO) production by murine LPS-stimulated peritoneal macrophages using the Griess technique. In addition, the ability of SpE to stabilize membranes was assessed using a model of hemolysis induced by heat on murine erythrocytes. Gene expression of Th1-cell-specific Tbx21 transcription factor (TBET), zinc-finger transcription factor-3 (GATA3), and nuclear factor-κB (NFKB) in murine spleen cells were assessed by quantitative Polymerase Chain Reaction (qRT-PCR).
SpE at 15, 30 and 60µg/mL significantly attenuated cell proliferation, decreased IL-4 release, reduced NO production and improved erythrocyte membrane stabilization in a concentration-dependent manner. SpE was also able to decrease the release of IFN-γ without altering IL-10 levels. The mechanism whereby SpE decreased inflammatory markers may be related to the reduction of NFKB, TBET and GATA3 gene expression.
This study is the first to test the anti-inflammatory action of S. paniculatum. Herein, we provided evidence for the popular use of S. paniculatum in inflammatory conditions. Additional studies must be conducted to further explore the anti-inflammatory potential of SpE and to elucidate possible clinical applications.
[Display omitted]</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2017.07.014</identifier><identifier>PMID: 28729226</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Animals ; Anti-inflammatory ; Cytokines - metabolism ; Ethnopharmacology ; GATA3 ; GATA3 Transcription Factor - genetics ; GATA3 Transcription Factor - metabolism ; Gene Expression Regulation - drug effects ; Inflammation - drug therapy ; Inflammation - metabolism ; Male ; Mice ; Mice, Inbred BALB C ; NF-kappa B - genetics ; NF-kappa B - metabolism ; NF-κB ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Solanum - chemistry ; Solanum paniculatum ; T-bet ; T-Box Domain Proteins - genetics ; T-Box Domain Proteins - metabolism</subject><ispartof>Journal of ethnopharmacology, 2017-09, Vol.209, p.32-40</ispartof><rights>2017 Elsevier Ireland Ltd</rights><rights>Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c268t-731d7ddc199ec81ada87b6d6ca63892b1ddcca63139976a707fd03ff59891c513</citedby><cites>FETCH-LOGICAL-c268t-731d7ddc199ec81ada87b6d6ca63892b1ddcca63139976a707fd03ff59891c513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2017.07.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28729226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rios, Raimon</creatorcontrib><creatorcontrib>Silva, Hugo Bernardino Ferreira da</creatorcontrib><creatorcontrib>Carneiro, Norma Vilany Queiroz</creatorcontrib><creatorcontrib>Pires, Anaque de Oliveira</creatorcontrib><creatorcontrib>Carneiro, Tamires Cana Brasil</creatorcontrib><creatorcontrib>Costa, Ryan dos Santos</creatorcontrib><creatorcontrib>Marques, Cintia Rodrigues</creatorcontrib><creatorcontrib>Machado, Marta Santos Serafim</creatorcontrib><creatorcontrib>Velozo, Eudes da Silva</creatorcontrib><creatorcontrib>Silva, Telma M.G. da</creatorcontrib><creatorcontrib>Silva, Tania M.S. da</creatorcontrib><creatorcontrib>Conceição, Adilva de Souza</creatorcontrib><creatorcontrib>Alcântara-Neves, Neuza Maria</creatorcontrib><creatorcontrib>Figueiredo, Camila Alexandrina</creatorcontrib><title>Solanum paniculatum L. decreases levels of inflammatory cytokines by reducing NFKB, TBET and GATA3 gene expression in vitro</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Solanum paniculatum L., popularly known as jurubeba, is a common subtropical plant from Brazil, Paraguay, Bolivia and Argentina, that is used in folk medicine for the treatment of anemia, gastrointestinal disorders and inflammatory conditions in general. In addition to that, an ethnobotanical survey in “Todos os Santos” Bay have pointed out S. paniculatum as an herb to treat asthma. Previous publications have shown that S. paniculatum possesses antibiotic, antioxidant and modulatory effects on gastric acid secretion; however, its anti-inflammatory potential remains unexplored.
Herein, we analyzed the S. paniculatum fruits hexane extract (SpE) for the presence of stigmasterol and β-sitosterol and investigated the anti-inflammatory effect of SpE in vitro.
SpE was subjected to high-performance liquid chromatography (HPLC) for standardization and quantification of stigmasterol and β-sitosterol. Spleen cells from BALB/c mice were cultivated and stimulated with pokeweed mitogen and also exposed to 15, 30 and 60µg/mL of SpE. Following treatment, levels of IFN-γ, IL-4 and IL-10 in the culture supernatants were assessed by ELISA. We also evaluated nitric oxide (NO) production by murine LPS-stimulated peritoneal macrophages using the Griess technique. In addition, the ability of SpE to stabilize membranes was assessed using a model of hemolysis induced by heat on murine erythrocytes. Gene expression of Th1-cell-specific Tbx21 transcription factor (TBET), zinc-finger transcription factor-3 (GATA3), and nuclear factor-κB (NFKB) in murine spleen cells were assessed by quantitative Polymerase Chain Reaction (qRT-PCR).
SpE at 15, 30 and 60µg/mL significantly attenuated cell proliferation, decreased IL-4 release, reduced NO production and improved erythrocyte membrane stabilization in a concentration-dependent manner. SpE was also able to decrease the release of IFN-γ without altering IL-10 levels. The mechanism whereby SpE decreased inflammatory markers may be related to the reduction of NFKB, TBET and GATA3 gene expression.
This study is the first to test the anti-inflammatory action of S. paniculatum. Herein, we provided evidence for the popular use of S. paniculatum in inflammatory conditions. Additional studies must be conducted to further explore the anti-inflammatory potential of SpE and to elucidate possible clinical applications.
[Display omitted]</description><subject>Animals</subject><subject>Anti-inflammatory</subject><subject>Cytokines - metabolism</subject><subject>Ethnopharmacology</subject><subject>GATA3</subject><subject>GATA3 Transcription Factor - genetics</subject><subject>GATA3 Transcription Factor - metabolism</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>NF-kappa B - genetics</subject><subject>NF-kappa B - metabolism</subject><subject>NF-κB</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Solanum - chemistry</subject><subject>Solanum paniculatum</subject><subject>T-bet</subject><subject>T-Box Domain Proteins - genetics</subject><subject>T-Box Domain Proteins - metabolism</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVoSDYfPyCXomMPtaux15ZFT5uQj9IlOWRzFlppHLS1JVeyly7589GyaY-FgRmYZ16Yh5ArYDkwqL9t8g0OecGA5ywVzI_IDBpeZLzi5ScyYyVvsobP4ZScxbhhjHGYsxNyWiRIFEU9I2_PvlNu6umgnNVTp8Y0L3NqUAdUESPtcItdpL6l1rWd6ns1-rCjejf6X9YlYL2jAc2krXulj3c_r7_S1fXtiipn6P1itSjpKzqk-GcIGKP1LuXQrR2DvyDHreoiXn70c_Jyd7u6eciWT_c_bhbLTBd1M2a8BMON0SAE6gaUUQ1f16bWqi4bUawh7fYzlELwWnHGW8PKtq1EI0BXUJ6TL4fcIfjfE8ZR9jZq7NLj6KcoIamoWMVEnVA4oDr4GAO2cgi2V2Engcm9c7mRybncO5csFczTzeeP-Gndo_l38VdyAr4fgOQRtxaDjNqi02hsQD1K4-1_4t8BViGSNQ</recordid><startdate>20170914</startdate><enddate>20170914</enddate><creator>Rios, Raimon</creator><creator>Silva, Hugo Bernardino Ferreira da</creator><creator>Carneiro, Norma Vilany Queiroz</creator><creator>Pires, Anaque de Oliveira</creator><creator>Carneiro, Tamires Cana Brasil</creator><creator>Costa, Ryan dos Santos</creator><creator>Marques, Cintia Rodrigues</creator><creator>Machado, Marta Santos Serafim</creator><creator>Velozo, Eudes da Silva</creator><creator>Silva, Telma M.G. da</creator><creator>Silva, Tania M.S. da</creator><creator>Conceição, Adilva de Souza</creator><creator>Alcântara-Neves, Neuza Maria</creator><creator>Figueiredo, Camila Alexandrina</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170914</creationdate><title>Solanum paniculatum L. decreases levels of inflammatory cytokines by reducing NFKB, TBET and GATA3 gene expression in vitro</title><author>Rios, Raimon ; 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In addition to that, an ethnobotanical survey in “Todos os Santos” Bay have pointed out S. paniculatum as an herb to treat asthma. Previous publications have shown that S. paniculatum possesses antibiotic, antioxidant and modulatory effects on gastric acid secretion; however, its anti-inflammatory potential remains unexplored.
Herein, we analyzed the S. paniculatum fruits hexane extract (SpE) for the presence of stigmasterol and β-sitosterol and investigated the anti-inflammatory effect of SpE in vitro.
SpE was subjected to high-performance liquid chromatography (HPLC) for standardization and quantification of stigmasterol and β-sitosterol. Spleen cells from BALB/c mice were cultivated and stimulated with pokeweed mitogen and also exposed to 15, 30 and 60µg/mL of SpE. Following treatment, levels of IFN-γ, IL-4 and IL-10 in the culture supernatants were assessed by ELISA. We also evaluated nitric oxide (NO) production by murine LPS-stimulated peritoneal macrophages using the Griess technique. In addition, the ability of SpE to stabilize membranes was assessed using a model of hemolysis induced by heat on murine erythrocytes. Gene expression of Th1-cell-specific Tbx21 transcription factor (TBET), zinc-finger transcription factor-3 (GATA3), and nuclear factor-κB (NFKB) in murine spleen cells were assessed by quantitative Polymerase Chain Reaction (qRT-PCR).
SpE at 15, 30 and 60µg/mL significantly attenuated cell proliferation, decreased IL-4 release, reduced NO production and improved erythrocyte membrane stabilization in a concentration-dependent manner. SpE was also able to decrease the release of IFN-γ without altering IL-10 levels. The mechanism whereby SpE decreased inflammatory markers may be related to the reduction of NFKB, TBET and GATA3 gene expression.
This study is the first to test the anti-inflammatory action of S. paniculatum. Herein, we provided evidence for the popular use of S. paniculatum in inflammatory conditions. Additional studies must be conducted to further explore the anti-inflammatory potential of SpE and to elucidate possible clinical applications.
[Display omitted]</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>28729226</pmid><doi>10.1016/j.jep.2017.07.014</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of ethnopharmacology, 2017-09, Vol.209, p.32-40 |
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| subjects | Animals Anti-inflammatory Cytokines - metabolism Ethnopharmacology GATA3 GATA3 Transcription Factor - genetics GATA3 Transcription Factor - metabolism Gene Expression Regulation - drug effects Inflammation - drug therapy Inflammation - metabolism Male Mice Mice, Inbred BALB C NF-kappa B - genetics NF-kappa B - metabolism NF-κB Plant Extracts - chemistry Plant Extracts - pharmacology Solanum - chemistry Solanum paniculatum T-bet T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism |
| title | Solanum paniculatum L. decreases levels of inflammatory cytokines by reducing NFKB, TBET and GATA3 gene expression in vitro |
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