Mechanism of Nicotinamide Inhibition and Transglycosidation by Sir2 Histone/Protein Deacetylases

Silent information regulator 2 (Sir2) enzymes catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine ϵ-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins have been show...

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Veröffentlicht in:	The Journal of biological chemistry 2003-12, Vol.278 (51), p.50985-50998
Hauptverfasser:	Jackson, Michael D., Schmidt, Manning T., Oppenheimer, Norman J., Denu, John M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Catalysis Glycosylation Histone Deacetylases - genetics Histone Deacetylases - physiology Humans Kinetics Models, Chemical NAD - chemistry Niacinamide - antagonists & inhibitors nicotinamide O-acetyl-ADP-ribose Pyridines - chemistry Ribose - chemistry Silent Information Regulator Proteins, Saccharomyces cerevisiae - genetics Silent Information Regulator Proteins, Saccharomyces cerevisiae - physiology Sir2 protein Sirtuin 1 Sirtuin 2 Sirtuins - genetics Sirtuins - physiology
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