Vinyl Acetate Decreases Intracellular pH in Rat Nasal Epithelial Cells

Vinyl acetate is a synthetic organic ester that has been shown to produce nasal tumors in rats following exposure to 600 ppm in air. The proposed mechanism of action involves the metabolism of vinyl acetate by carboxylesterases and the production of protons leading to cellular acidification. While v...

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Veröffentlicht in:	Toxicological sciences 2003-10, Vol.75 (2), p.423-431
Hauptverfasser:	Lantz, R. Clark, Orozco, Jason, Bogdanffy, Matthew S.
Format:	Artikel
Sprache:	eng
Schlagworte:	acidification Animals Benzopyrans Biological and medical sciences Carboxylesterase - antagonists & inhibitors Carcinogenesis, carcinogens and anticarcinogens Cells, Cultured Chemical agents confocal microscopy dose-response Dose-Response Relationship, Drug Drug Antagonism Enzyme Inhibitors - pharmacology epithelial cells Hydrogen-Ion Concentration - drug effects Male Medical sciences Microscopy, Confocal Naphthols - metabolism nasal epithelial cells Nitrophenols - pharmacology Olfactory Mucosa - drug effects Olfactory Mucosa - metabolism Olfactory Mucosa - pathology Rats Rats, Inbred Strains Rhodamines - metabolism Tumors vinyl acetate Vinyl Compounds - toxicity
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