UV-induced de novo protein synthesis enhances nucleotide excision repair efficiency in a transcription-dependent manner in S. cerevisiae

DNA damage results in the up-regulation of several genes involved in different cellular physiological processes, such as the nucleotide excision repair (NER) mechanism that copes with a broad range of DNA alterations, including the carcinogenic ultraviolet (UV) light-induced pyrimidine dimers (PDs)....

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Veröffentlicht in:	DNA repair 2003-11, Vol.2 (11), p.1185-1197
Hauptverfasser:	Al-Moghrabi, Nisreen M, Al-Sharif, Ibtehaj S, Aboussekhra, Abdelilah
Format:	Artikel
Sprache:	eng
Schlagworte:	cycloheximide Cycloheximide - pharmacology de novo protein synthesis DNA Damage DNA Repair DNA, Fungal - radiation effects GAL10 gene Nucleotide excision repair Protein Synthesis Inhibitors - pharmacology Pyrimidine Dimers - metabolism S. cerevisiae Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - biosynthesis Saccharomyces cerevisiae Proteins - radiation effects Transcription, Genetic Transcription-coupled repair Ultraviolet Rays URA3 gene UV damage
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