Altered pulmonary gas transfer capacity and capillary blood volume in pediatric Crohn's disease

Objectives To describe diffusing capacity for carbon monoxide (DLCO) and its components, that is, membrane diffusing capacity (DmCO) and pulmonary capillary blood volume (Vc) in children with Crohn's disease (CD), and to investigate the correlation between these parameters and disease activity....

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Veröffentlicht in:	Pediatric pulmonology 2017-08, Vol.52 (8), p.1051-1056
Hauptverfasser:	Verstraete, Marie, Choukroun, Marie‐Luce, Siao‐Him Fa, Valerie, Fayon, Michael, Rebouissoux, Laurent, Enaud, Raphael, Lamireau, Thierry
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Sprache:	eng
Schlagworte:	Adolescent Blood Volume Capillaries - physiology Carbon monoxide Carbon Monoxide - metabolism Child Crohn Disease - metabolism Crohn Disease - physiopathology Crohn's disease Health risk assessment Humans Lung - physiopathology membrane diffusing capacity Nitric Oxide - metabolism Pulmonary Diffusing Capacity pulmonary diffusing capacity for carbon monoxide respiratory function tests
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container_title	Pediatric pulmonology
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creator	Verstraete, Marie Choukroun, Marie‐Luce Siao‐Him Fa, Valerie Fayon, Michael Rebouissoux, Laurent Enaud, Raphael Lamireau, Thierry
description	Objectives To describe diffusing capacity for carbon monoxide (DLCO) and its components, that is, membrane diffusing capacity (DmCO) and pulmonary capillary blood volume (Vc) in children with Crohn's disease (CD), and to investigate the correlation between these parameters and disease activity. Working Hypothesis The most common lung function abnormalities are a reduced pulmonary DLCO and small airways disorders which are in many instances, clinically silent. No valid explanations have been proposed regarding the modifications in gas transfer capacity in active CD. Methods DLCO, DmCO, and Vc were measured in 25 CD children by the simultaneous single breath lung diffusing capacity method using nitric oxide (NO) and carbon monoxide (CO) transfer. These parameters were analyzed in relation to the CD disease activity index. Results DLCO (90.7 ± 4.5% vs 128.5 ± 4.7%; P
doi_str_mv	10.1002/ppul.23703
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Working Hypothesis The most common lung function abnormalities are a reduced pulmonary DLCO and small airways disorders which are in many instances, clinically silent. No valid explanations have been proposed regarding the modifications in gas transfer capacity in active CD. Methods DLCO, DmCO, and Vc were measured in 25 CD children by the simultaneous single breath lung diffusing capacity method using nitric oxide (NO) and carbon monoxide (CO) transfer. These parameters were analyzed in relation to the CD disease activity index. Results DLCO (90.7 ± 4.5% vs 128.5 ± 4.7%; P < 0.001), Dm (92.4 ± 5.9% vs 125.6 ± 6.3%; P < 0.001), and Vc (72.6 ± 3.7% vs 104.4 ± 4.0%; P < 0.001) were significantly decreased in the active CD group in comparison with the inactive CD group. DLCO (r = −0.60; P < 0.01), DmCO (r = −0.45; P < 0.01), and Vc (r = −0.60; P < 0.01) were inversely correlated to the PCDAI. In 8 patients who participated to the study at initial diagnosis then during remission, DmCO and Vc increased significantly between the active and the inactive period of the disease. Conclusion Pulmonary diffusing capacity is impaired in children with active CD, mainly because of a decrease of the pulmonary capillary volume.]]></description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.23703</identifier><identifier>PMID: 28719106</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Blood Volume ; Capillaries - physiology ; Carbon monoxide ; Carbon Monoxide - metabolism ; Child ; Crohn Disease - metabolism ; Crohn Disease - physiopathology ; Crohn's disease ; Health risk assessment ; Humans ; Lung - physiopathology ; membrane diffusing capacity ; Nitric Oxide - metabolism ; Pulmonary Diffusing Capacity ; pulmonary diffusing capacity for carbon monoxide ; respiratory function tests</subject><ispartof>Pediatric pulmonology, 2017-08, Vol.52 (8), p.1051-1056</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3573-14afd32e62b6744a3a75850154a499ba9dd9be78ed2ef809ea7a280a2575a68b3</citedby><cites>FETCH-LOGICAL-c3573-14afd32e62b6744a3a75850154a499ba9dd9be78ed2ef809ea7a280a2575a68b3</cites><orcidid>0000-0002-5777-8492 ; 0000-0003-1223-1108</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fppul.23703$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fppul.23703$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28719106$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verstraete, Marie</creatorcontrib><creatorcontrib>Choukroun, Marie‐Luce</creatorcontrib><creatorcontrib>Siao‐Him Fa, Valerie</creatorcontrib><creatorcontrib>Fayon, Michael</creatorcontrib><creatorcontrib>Rebouissoux, Laurent</creatorcontrib><creatorcontrib>Enaud, Raphael</creatorcontrib><creatorcontrib>Lamireau, Thierry</creatorcontrib><title>Altered pulmonary gas transfer capacity and capillary blood volume in pediatric Crohn's disease</title><title>Pediatric pulmonology</title><addtitle>Pediatr Pulmonol</addtitle><description><![CDATA[Objectives To describe diffusing capacity for carbon monoxide (DLCO) and its components, that is, membrane diffusing capacity (DmCO) and pulmonary capillary blood volume (Vc) in children with Crohn's disease (CD), and to investigate the correlation between these parameters and disease activity. Working Hypothesis The most common lung function abnormalities are a reduced pulmonary DLCO and small airways disorders which are in many instances, clinically silent. No valid explanations have been proposed regarding the modifications in gas transfer capacity in active CD. Methods DLCO, DmCO, and Vc were measured in 25 CD children by the simultaneous single breath lung diffusing capacity method using nitric oxide (NO) and carbon monoxide (CO) transfer. These parameters were analyzed in relation to the CD disease activity index. Results DLCO (90.7 ± 4.5% vs 128.5 ± 4.7%; P < 0.001), Dm (92.4 ± 5.9% vs 125.6 ± 6.3%; P < 0.001), and Vc (72.6 ± 3.7% vs 104.4 ± 4.0%; P < 0.001) were significantly decreased in the active CD group in comparison with the inactive CD group. DLCO (r = −0.60; P < 0.01), DmCO (r = −0.45; P < 0.01), and Vc (r = −0.60; P < 0.01) were inversely correlated to the PCDAI. In 8 patients who participated to the study at initial diagnosis then during remission, DmCO and Vc increased significantly between the active and the inactive period of the disease. Conclusion Pulmonary diffusing capacity is impaired in children with active CD, mainly because of a decrease of the pulmonary capillary volume.]]></description><subject>Adolescent</subject><subject>Blood Volume</subject><subject>Capillaries - physiology</subject><subject>Carbon monoxide</subject><subject>Carbon Monoxide - metabolism</subject><subject>Child</subject><subject>Crohn Disease - metabolism</subject><subject>Crohn Disease - physiopathology</subject><subject>Crohn's disease</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Lung - physiopathology</subject><subject>membrane diffusing capacity</subject><subject>Nitric Oxide - metabolism</subject><subject>Pulmonary Diffusing Capacity</subject><subject>pulmonary diffusing capacity for carbon monoxide</subject><subject>respiratory function tests</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1r3DAQBmBRUppt0kt-QBDk0FJwqg9Lso5h6RcsNIfmLMbWuFWwLUeyW_bfV5tNeuihJzHo4WXmJeSCs2vOmPgwz-twLaRh8gXZcGZtxWqrT8imMUpVutHylLzO-Z6x8mf5K3IqGsMtZ3pD3M2wYEJPS8YYJ0h7-gMyXRJMucdEO5ihC8uewuQPQxiGg2mHGD39FYd1RBomOqMPsKTQ0W2KP6e3mfqQETKek5c9DBnfPL1n5O7Tx-_bL9Xu2-ev25td1UllZMVr6L0UqEWrTV2DBKMaxbiqoba2Beu9bdE06AX2DbMIBkTDQCijQDetPCPvjrlzig8r5sWNIXdYtp0wrtlxKziXSnBT6NU_9D6uaSrbFcWtVsIwXdT7o-pSzDlh7-YUxnK748wdaneH2t1j7QVfPkWu7Yj-L33uuQB-BL_DgPv_RLnb27vdMfQPJ22NUw</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Verstraete, Marie</creator><creator>Choukroun, Marie‐Luce</creator><creator>Siao‐Him Fa, Valerie</creator><creator>Fayon, Michael</creator><creator>Rebouissoux, Laurent</creator><creator>Enaud, Raphael</creator><creator>Lamireau, Thierry</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5777-8492</orcidid><orcidid>https://orcid.org/0000-0003-1223-1108</orcidid></search><sort><creationdate>201708</creationdate><title>Altered pulmonary gas transfer capacity and capillary blood volume in pediatric Crohn's disease</title><author>Verstraete, Marie ; Choukroun, Marie‐Luce ; Siao‐Him Fa, Valerie ; Fayon, Michael ; Rebouissoux, Laurent ; Enaud, Raphael ; Lamireau, Thierry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3573-14afd32e62b6744a3a75850154a499ba9dd9be78ed2ef809ea7a280a2575a68b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Blood Volume</topic><topic>Capillaries - physiology</topic><topic>Carbon monoxide</topic><topic>Carbon Monoxide - metabolism</topic><topic>Child</topic><topic>Crohn Disease - metabolism</topic><topic>Crohn Disease - physiopathology</topic><topic>Crohn's disease</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Lung - physiopathology</topic><topic>membrane diffusing capacity</topic><topic>Nitric Oxide - metabolism</topic><topic>Pulmonary Diffusing Capacity</topic><topic>pulmonary diffusing capacity for carbon monoxide</topic><topic>respiratory function tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verstraete, Marie</creatorcontrib><creatorcontrib>Choukroun, Marie‐Luce</creatorcontrib><creatorcontrib>Siao‐Him Fa, Valerie</creatorcontrib><creatorcontrib>Fayon, Michael</creatorcontrib><creatorcontrib>Rebouissoux, Laurent</creatorcontrib><creatorcontrib>Enaud, Raphael</creatorcontrib><creatorcontrib>Lamireau, Thierry</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verstraete, Marie</au><au>Choukroun, Marie‐Luce</au><au>Siao‐Him Fa, Valerie</au><au>Fayon, Michael</au><au>Rebouissoux, Laurent</au><au>Enaud, Raphael</au><au>Lamireau, Thierry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered pulmonary gas transfer capacity and capillary blood volume in pediatric Crohn's disease</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr Pulmonol</addtitle><date>2017-08</date><risdate>2017</risdate><volume>52</volume><issue>8</issue><spage>1051</spage><epage>1056</epage><pages>1051-1056</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><abstract><![CDATA[Objectives To describe diffusing capacity for carbon monoxide (DLCO) and its components, that is, membrane diffusing capacity (DmCO) and pulmonary capillary blood volume (Vc) in children with Crohn's disease (CD), and to investigate the correlation between these parameters and disease activity. Working Hypothesis The most common lung function abnormalities are a reduced pulmonary DLCO and small airways disorders which are in many instances, clinically silent. No valid explanations have been proposed regarding the modifications in gas transfer capacity in active CD. Methods DLCO, DmCO, and Vc were measured in 25 CD children by the simultaneous single breath lung diffusing capacity method using nitric oxide (NO) and carbon monoxide (CO) transfer. These parameters were analyzed in relation to the CD disease activity index. Results DLCO (90.7 ± 4.5% vs 128.5 ± 4.7%; P < 0.001), Dm (92.4 ± 5.9% vs 125.6 ± 6.3%; P < 0.001), and Vc (72.6 ± 3.7% vs 104.4 ± 4.0%; P < 0.001) were significantly decreased in the active CD group in comparison with the inactive CD group. DLCO (r = −0.60; P < 0.01), DmCO (r = −0.45; P < 0.01), and Vc (r = −0.60; P < 0.01) were inversely correlated to the PCDAI. In 8 patients who participated to the study at initial diagnosis then during remission, DmCO and Vc increased significantly between the active and the inactive period of the disease. Conclusion Pulmonary diffusing capacity is impaired in children with active CD, mainly because of a decrease of the pulmonary capillary volume.]]></abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28719106</pmid><doi>10.1002/ppul.23703</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5777-8492</orcidid><orcidid>https://orcid.org/0000-0003-1223-1108</orcidid></addata></record>
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subjects	Adolescent Blood Volume Capillaries - physiology Carbon monoxide Carbon Monoxide - metabolism Child Crohn Disease - metabolism Crohn Disease - physiopathology Crohn's disease Health risk assessment Humans Lung - physiopathology membrane diffusing capacity Nitric Oxide - metabolism Pulmonary Diffusing Capacity pulmonary diffusing capacity for carbon monoxide respiratory function tests
title	Altered pulmonary gas transfer capacity and capillary blood volume in pediatric Crohn's disease
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