Changing prevalence of severe congenital heart disease: Results from the National Register for Congenital Heart Defects in Germany
Objective To assess the prevalence of congenital heart disease (CHD) in Germany in relation to phenotypes, severity and gender. Design Cross‐sectional registry study. Setting We analyzed data from patients with CHD born between 1996 and 2015. Patients A total of 26 630 patients, registered with the...
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| Veröffentlicht in: | Congenital heart disease 2017-11, Vol.12 (6), p.787-793 |
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| creator | Pfitzer, Constanze Helm, Paul C. Ferentzi, Hannah Rosenthal, Lisa‐Maria Bauer, Ulrike M. M. Berger, Felix Schmitt, Katharina R. L. |
| description | Objective
To assess the prevalence of congenital heart disease (CHD) in Germany in relation to phenotypes, severity and gender.
Design
Cross‐sectional registry study.
Setting
We analyzed data from patients with CHD born between 1996 and 2015.
Patients
A total of 26 630 patients, registered with the NRCHD, were born between 1996 and 2015. 10 927 patients were excluded from the current analysis due to prior registration with the NRCHD under the German PAN Prevalence Study, which showed a potential bias in the inclusion of this patient population (proportion of mild cardiac lesions was comparatively high due to improved diagnostic capability for earlier identifying minor lesions). At least 15 703 patients with demographic data and detailed medical information were included in the current study.
Interventions
None.
Outcome Measures
Prevalence of CHD in Germany differentiated into gender, severity, and phenotype.
Results
In total, 15 703 patients with CHD (47.1% female) were included in this study. The five most common phenotypes were found to be ventricular septal defect (19.2%), atrial septal defect (13.0%), Tetralogy of Fallot (9.3%), univentricular heart (9.4%), and coractation of the aortae (7.0%). The prevalence of CHD in regard to severity changed over the duration of the observation period. From 1996 to 2007, the number of simple CHD rose steadily (P |
| doi_str_mv | 10.1111/chd.12515 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1921135076</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1921135076</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3535-59b3bd583891d70a64a8170ee7fde2078afe4660117c32b6b944b851fe90abab3</originalsourceid><addsrcrecordid>eNp10U1LwzAcx_Egis6Hg29AAl70MJc0TdN6k043QRREwVtJ23-2SJvMpJ3s6is3Oh9AsJf08MkXwg-hQ0rOaPhG1bw-oxGnfAMNqIjFkKSEbX7_i-xpB-16_0xInDCRbqOdKBU0o3E0QG_5XJqZNjO8cLCUDZgKsFXYwxIc4MqaGRjdyQbPQboO19qD9HCO78H3TeexcrbF3Rzwrey0NQHew0z7DhxW1uH8NzD9DIxBQRXuaYMn4FppVvtoS8nGw8HXuYcery4f8unw5m5ynV_cDCvGGR_yrGRlzVOWZrQWRCaxTKkgAELVEBGRSgVxkhBKRcWiMimzOC5TThVkRJayZHvoZN1dOPvSg--KVvsKmkYasL0vaBZRyjgRSaDHf-iz7V143IcShHPCmAjqdK0qZ713oIqF0610q4KS4mOYIgxTfA4T7NFXsS9bqH_k9xIBjNbgVTew-r9U5NPxOvkOH_yXuQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1970550337</pqid></control><display><type>article</type><title>Changing prevalence of severe congenital heart disease: Results from the National Register for Congenital Heart Defects in Germany</title><source>Tech Science Press</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Pfitzer, Constanze ; Helm, Paul C. ; Ferentzi, Hannah ; Rosenthal, Lisa‐Maria ; Bauer, Ulrike M. M. ; Berger, Felix ; Schmitt, Katharina R. L.</creator><creatorcontrib>Pfitzer, Constanze ; Helm, Paul C. ; Ferentzi, Hannah ; Rosenthal, Lisa‐Maria ; Bauer, Ulrike M. M. ; Berger, Felix ; Schmitt, Katharina R. L.</creatorcontrib><description>Objective
To assess the prevalence of congenital heart disease (CHD) in Germany in relation to phenotypes, severity and gender.
Design
Cross‐sectional registry study.
Setting
We analyzed data from patients with CHD born between 1996 and 2015.
Patients
A total of 26 630 patients, registered with the NRCHD, were born between 1996 and 2015. 10 927 patients were excluded from the current analysis due to prior registration with the NRCHD under the German PAN Prevalence Study, which showed a potential bias in the inclusion of this patient population (proportion of mild cardiac lesions was comparatively high due to improved diagnostic capability for earlier identifying minor lesions). At least 15 703 patients with demographic data and detailed medical information were included in the current study.
Interventions
None.
Outcome Measures
Prevalence of CHD in Germany differentiated into gender, severity, and phenotype.
Results
In total, 15 703 patients with CHD (47.1% female) were included in this study. The five most common phenotypes were found to be ventricular septal defect (19.2%), atrial septal defect (13.0%), Tetralogy of Fallot (9.3%), univentricular heart (9.4%), and coractation of the aortae (7.0%). The prevalence of CHD in regard to severity changed over the duration of the observation period. From 1996 to 2007, the number of simple CHD rose steadily (P < .001), whereas the number of severe CHD has grown significantly since 2008/2009 (P < .001). In regard to gender, the prevalence of simple CHD was higher in females, whereas complex lesions were more common in males (P < .001).
Conclusions
Our study shows a growing number of registered severe CHD in the recent decade in Germany. This development is noteworthy as it implicates a growing demand for first intensive hospital care, expert pediatric cardiologic aftercare, and consequently higher economic impact for this patient population.</description><identifier>ISSN: 1747-079X</identifier><identifier>EISSN: 1747-0803</identifier><identifier>DOI: 10.1111/chd.12515</identifier><identifier>PMID: 28719142</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Cardiovascular disease ; Child ; Child, Preschool ; Congenital diseases ; congenital heart disease ; Cross-Sectional Studies ; Demographics ; Diagnostic systems ; Economic impact ; Female ; Gender ; Germany - epidemiology ; Heart ; Heart Defects, Congenital - diagnosis ; Heart Defects, Congenital - epidemiology ; Humans ; Impact analysis ; Infant ; Lesions ; Male ; Patients ; Phenotype ; Population Surveillance ; prenatal diagnostic ; Prevalence ; Registries ; Retrospective Studies ; Severity of Illness Index ; Sex Distribution ; Young Adult</subject><ispartof>Congenital heart disease, 2017-11, Vol.12 (6), p.787-793</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-59b3bd583891d70a64a8170ee7fde2078afe4660117c32b6b944b851fe90abab3</citedby><cites>FETCH-LOGICAL-c3535-59b3bd583891d70a64a8170ee7fde2078afe4660117c32b6b944b851fe90abab3</cites><orcidid>0000-0003-1956-5573 ; 0000-0002-1868-4266</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fchd.12515$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fchd.12515$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28719142$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pfitzer, Constanze</creatorcontrib><creatorcontrib>Helm, Paul C.</creatorcontrib><creatorcontrib>Ferentzi, Hannah</creatorcontrib><creatorcontrib>Rosenthal, Lisa‐Maria</creatorcontrib><creatorcontrib>Bauer, Ulrike M. M.</creatorcontrib><creatorcontrib>Berger, Felix</creatorcontrib><creatorcontrib>Schmitt, Katharina R. L.</creatorcontrib><title>Changing prevalence of severe congenital heart disease: Results from the National Register for Congenital Heart Defects in Germany</title><title>Congenital heart disease</title><addtitle>Congenit Heart Dis</addtitle><description>Objective
To assess the prevalence of congenital heart disease (CHD) in Germany in relation to phenotypes, severity and gender.
Design
Cross‐sectional registry study.
Setting
We analyzed data from patients with CHD born between 1996 and 2015.
Patients
A total of 26 630 patients, registered with the NRCHD, were born between 1996 and 2015. 10 927 patients were excluded from the current analysis due to prior registration with the NRCHD under the German PAN Prevalence Study, which showed a potential bias in the inclusion of this patient population (proportion of mild cardiac lesions was comparatively high due to improved diagnostic capability for earlier identifying minor lesions). At least 15 703 patients with demographic data and detailed medical information were included in the current study.
Interventions
None.
Outcome Measures
Prevalence of CHD in Germany differentiated into gender, severity, and phenotype.
Results
In total, 15 703 patients with CHD (47.1% female) were included in this study. The five most common phenotypes were found to be ventricular septal defect (19.2%), atrial septal defect (13.0%), Tetralogy of Fallot (9.3%), univentricular heart (9.4%), and coractation of the aortae (7.0%). The prevalence of CHD in regard to severity changed over the duration of the observation period. From 1996 to 2007, the number of simple CHD rose steadily (P < .001), whereas the number of severe CHD has grown significantly since 2008/2009 (P < .001). In regard to gender, the prevalence of simple CHD was higher in females, whereas complex lesions were more common in males (P < .001).
Conclusions
Our study shows a growing number of registered severe CHD in the recent decade in Germany. This development is noteworthy as it implicates a growing demand for first intensive hospital care, expert pediatric cardiologic aftercare, and consequently higher economic impact for this patient population.</description><subject>Adolescent</subject><subject>Cardiovascular disease</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Congenital diseases</subject><subject>congenital heart disease</subject><subject>Cross-Sectional Studies</subject><subject>Demographics</subject><subject>Diagnostic systems</subject><subject>Economic impact</subject><subject>Female</subject><subject>Gender</subject><subject>Germany - epidemiology</subject><subject>Heart</subject><subject>Heart Defects, Congenital - diagnosis</subject><subject>Heart Defects, Congenital - epidemiology</subject><subject>Humans</subject><subject>Impact analysis</subject><subject>Infant</subject><subject>Lesions</subject><subject>Male</subject><subject>Patients</subject><subject>Phenotype</subject><subject>Population Surveillance</subject><subject>prenatal diagnostic</subject><subject>Prevalence</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>Sex Distribution</subject><subject>Young Adult</subject><issn>1747-079X</issn><issn>1747-0803</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10U1LwzAcx_Egis6Hg29AAl70MJc0TdN6k043QRREwVtJ23-2SJvMpJ3s6is3Oh9AsJf08MkXwg-hQ0rOaPhG1bw-oxGnfAMNqIjFkKSEbX7_i-xpB-16_0xInDCRbqOdKBU0o3E0QG_5XJqZNjO8cLCUDZgKsFXYwxIc4MqaGRjdyQbPQboO19qD9HCO78H3TeexcrbF3Rzwrey0NQHew0z7DhxW1uH8NzD9DIxBQRXuaYMn4FppVvtoS8nGw8HXuYcery4f8unw5m5ynV_cDCvGGR_yrGRlzVOWZrQWRCaxTKkgAELVEBGRSgVxkhBKRcWiMimzOC5TThVkRJayZHvoZN1dOPvSg--KVvsKmkYasL0vaBZRyjgRSaDHf-iz7V143IcShHPCmAjqdK0qZ713oIqF0610q4KS4mOYIgxTfA4T7NFXsS9bqH_k9xIBjNbgVTew-r9U5NPxOvkOH_yXuQ</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Pfitzer, Constanze</creator><creator>Helm, Paul C.</creator><creator>Ferentzi, Hannah</creator><creator>Rosenthal, Lisa‐Maria</creator><creator>Bauer, Ulrike M. M.</creator><creator>Berger, Felix</creator><creator>Schmitt, Katharina R. L.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>JQ2</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1956-5573</orcidid><orcidid>https://orcid.org/0000-0002-1868-4266</orcidid></search><sort><creationdate>201711</creationdate><title>Changing prevalence of severe congenital heart disease: Results from the National Register for Congenital Heart Defects in Germany</title><author>Pfitzer, Constanze ; Helm, Paul C. ; Ferentzi, Hannah ; Rosenthal, Lisa‐Maria ; Bauer, Ulrike M. M. ; Berger, Felix ; Schmitt, Katharina R. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-59b3bd583891d70a64a8170ee7fde2078afe4660117c32b6b944b851fe90abab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Cardiovascular disease</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Congenital diseases</topic><topic>congenital heart disease</topic><topic>Cross-Sectional Studies</topic><topic>Demographics</topic><topic>Diagnostic systems</topic><topic>Economic impact</topic><topic>Female</topic><topic>Gender</topic><topic>Germany - epidemiology</topic><topic>Heart</topic><topic>Heart Defects, Congenital - diagnosis</topic><topic>Heart Defects, Congenital - epidemiology</topic><topic>Humans</topic><topic>Impact analysis</topic><topic>Infant</topic><topic>Lesions</topic><topic>Male</topic><topic>Patients</topic><topic>Phenotype</topic><topic>Population Surveillance</topic><topic>prenatal diagnostic</topic><topic>Prevalence</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>Sex Distribution</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pfitzer, Constanze</creatorcontrib><creatorcontrib>Helm, Paul C.</creatorcontrib><creatorcontrib>Ferentzi, Hannah</creatorcontrib><creatorcontrib>Rosenthal, Lisa‐Maria</creatorcontrib><creatorcontrib>Bauer, Ulrike M. M.</creatorcontrib><creatorcontrib>Berger, Felix</creatorcontrib><creatorcontrib>Schmitt, Katharina R. L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Congenital heart disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pfitzer, Constanze</au><au>Helm, Paul C.</au><au>Ferentzi, Hannah</au><au>Rosenthal, Lisa‐Maria</au><au>Bauer, Ulrike M. M.</au><au>Berger, Felix</au><au>Schmitt, Katharina R. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changing prevalence of severe congenital heart disease: Results from the National Register for Congenital Heart Defects in Germany</atitle><jtitle>Congenital heart disease</jtitle><addtitle>Congenit Heart Dis</addtitle><date>2017-11</date><risdate>2017</risdate><volume>12</volume><issue>6</issue><spage>787</spage><epage>793</epage><pages>787-793</pages><issn>1747-079X</issn><eissn>1747-0803</eissn><abstract>Objective
To assess the prevalence of congenital heart disease (CHD) in Germany in relation to phenotypes, severity and gender.
Design
Cross‐sectional registry study.
Setting
We analyzed data from patients with CHD born between 1996 and 2015.
Patients
A total of 26 630 patients, registered with the NRCHD, were born between 1996 and 2015. 10 927 patients were excluded from the current analysis due to prior registration with the NRCHD under the German PAN Prevalence Study, which showed a potential bias in the inclusion of this patient population (proportion of mild cardiac lesions was comparatively high due to improved diagnostic capability for earlier identifying minor lesions). At least 15 703 patients with demographic data and detailed medical information were included in the current study.
Interventions
None.
Outcome Measures
Prevalence of CHD in Germany differentiated into gender, severity, and phenotype.
Results
In total, 15 703 patients with CHD (47.1% female) were included in this study. The five most common phenotypes were found to be ventricular septal defect (19.2%), atrial septal defect (13.0%), Tetralogy of Fallot (9.3%), univentricular heart (9.4%), and coractation of the aortae (7.0%). The prevalence of CHD in regard to severity changed over the duration of the observation period. From 1996 to 2007, the number of simple CHD rose steadily (P < .001), whereas the number of severe CHD has grown significantly since 2008/2009 (P < .001). In regard to gender, the prevalence of simple CHD was higher in females, whereas complex lesions were more common in males (P < .001).
Conclusions
Our study shows a growing number of registered severe CHD in the recent decade in Germany. This development is noteworthy as it implicates a growing demand for first intensive hospital care, expert pediatric cardiologic aftercare, and consequently higher economic impact for this patient population.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28719142</pmid><doi>10.1111/chd.12515</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1956-5573</orcidid><orcidid>https://orcid.org/0000-0002-1868-4266</orcidid></addata></record> |
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| ispartof | Congenital heart disease, 2017-11, Vol.12 (6), p.787-793 |
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| source | Tech Science Press; MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Cardiovascular disease Child Child, Preschool Congenital diseases congenital heart disease Cross-Sectional Studies Demographics Diagnostic systems Economic impact Female Gender Germany - epidemiology Heart Heart Defects, Congenital - diagnosis Heart Defects, Congenital - epidemiology Humans Impact analysis Infant Lesions Male Patients Phenotype Population Surveillance prenatal diagnostic Prevalence Registries Retrospective Studies Severity of Illness Index Sex Distribution Young Adult |
| title | Changing prevalence of severe congenital heart disease: Results from the National Register for Congenital Heart Defects in Germany |
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