Chitosan oligosaccharides protect nucleus pulposus cells from hydrogen peroxide-induced apoptosis in a rat experimental model

Chitosan has been investigated for its protective effect on nucleus pulposus (NP) cells against intervertebral disc degeneration(IDD), but its high molecular weight prohibits its clinical application. The low molecular derivatives, chitosan oligosaccharides (COS) are easier to absorb; however, the p...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2017-09, Vol.93, p.807-815
Hauptverfasser:	Jia, Peng, Yu, Ling, Tao, Chunjie, Dai, Guo, Zhang, Zhengpei, Liu, Shiqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Chitosan - pharmacology Chitosan oligosaccharides Hydrogen Peroxide - pharmacology Intervertebral Disc - drug effects Intervertebral Disc - metabolism Intervertebral disc degeneration Intervertebral Disc Degeneration - drug therapy Intervertebral Disc Degeneration - metabolism Male Models, Animal Nucleus pulposus Nucleus Pulposus - drug effects Nucleus Pulposus - metabolism Oligosaccharides - pharmacology Oxidative Stress - drug effects Phosphatidylinositol 3-Kinases - metabolism PI3K/Akt pathway Protective Agents - pharmacology Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Signal Transduction - drug effects
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