Serotonin depletion increases seizure susceptibility and worsens neuropathological outcomes in kainate model of epilepsy

•Effects of kainate on hippocampal structure and function are dose-dependent.•Serotonin depletion worsens neurological outcome after kainate treatment.•Low levels of serotonin is one of the major risk factors for epilepsy. Serotonin is implicated in the regulation of seizures, but whether or not it...

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Veröffentlicht in:	Brain research bulletin 2017-09, Vol.134, p.109-120
Hauptverfasser:	Maia, Gisela H., Brazete, Cátia S., Soares, Joana I., Luz, Liliana L., Lukoyanov, Nikolai V.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Hydroxytryptamine Animals Disease Models, Animal Disease Susceptibility - metabolism Dorsal raphe Epilepsy - metabolism Epilepsy - pathology Epilepsy - psychology Fenclonine Hippocampal formation Hippocampus - metabolism Hippocampus - pathology Kainate Kainic Acid Male Maze Learning - physiology Memory Disorders - metabolism Memory Disorders - pathology Neurons - metabolism Neurons - pathology Rats, Wistar Seizures - metabolism Seizures - pathology Seizures - psychology Serotonin - deficiency Spatial Memory - physiology Temporal lobe epilepsy
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