Regional cerebral glucose metabolism in systemic lupus erythematosus patients with major depressive disorder
Abstract Objectives Depression is frequently observed in patients with systemic lupus erythematosus (SLE). Neuropsychiatric SLE (NPSLE) patients often exhibit cerebral hypometabolism, but the association between cerebral metabolism and depression remains unclear. To elucidate the features of cerebra...
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| Veröffentlicht in: | Journal of the neurological sciences 2017-08, Vol.379, p.127-130 |
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| creator | Saito, Tomoyuki Tamura, Maasa Chiba, Yuhei Katsuse, Omi Suda, Akira Kamada, Ayuko Ikura, Takahiro Abe, Kie Ogawa, Matsuyoshi Minegishi, Kaoru Yoshimi, Ryusuke Kirino, Yohei Ihata, Atsushi Hirayasu, Yoshio |
| description | Abstract Objectives Depression is frequently observed in patients with systemic lupus erythematosus (SLE). Neuropsychiatric SLE (NPSLE) patients often exhibit cerebral hypometabolism, but the association between cerebral metabolism and depression remains unclear. To elucidate the features of cerebral metabolism in SLE patients with depression, we performed brain 18F-fluoro- d -glucose positron emission tomography (FDG-PET) on SLE patients with and without major depressive disorder. Methods We performed brain FDG-PET on 20 SLE subjects (5 male, 15 female). The subjects were divided into two groups: subjects with major depressive disorder (DSLE) and subjects without major depressive disorder (non-DSLE). Cerebral glucose metabolism was analyzed using the three-dimensional stereotactic surface projection (3D-SSP) program. Regional metabolism was evaluated by stereotactic extraction estimation (SEE), in which the whole brain was divided into segments. Results Every SLE subject exhibited cerebral hypometabolism, in contrast to the normal healthy subjects. Regional analysis revealed a significantly lower ER in the left medial frontal gyrus ( p = 0.0055) and the right medial frontal gyrus ( p = 0.0022) in the DSLE group than in the non-DSLE group. Conclusion Hypometabolism in the medial frontal gyrus may be related to major depressive disorder in SLE. Larger studies are needed to clarify this relationship. |
| doi_str_mv | 10.1016/j.jns.2017.05.059 |
| format | Article |
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Neuropsychiatric SLE (NPSLE) patients often exhibit cerebral hypometabolism, but the association between cerebral metabolism and depression remains unclear. To elucidate the features of cerebral metabolism in SLE patients with depression, we performed brain 18F-fluoro- d -glucose positron emission tomography (FDG-PET) on SLE patients with and without major depressive disorder. Methods We performed brain FDG-PET on 20 SLE subjects (5 male, 15 female). The subjects were divided into two groups: subjects with major depressive disorder (DSLE) and subjects without major depressive disorder (non-DSLE). Cerebral glucose metabolism was analyzed using the three-dimensional stereotactic surface projection (3D-SSP) program. Regional metabolism was evaluated by stereotactic extraction estimation (SEE), in which the whole brain was divided into segments. Results Every SLE subject exhibited cerebral hypometabolism, in contrast to the normal healthy subjects. Regional analysis revealed a significantly lower ER in the left medial frontal gyrus ( p = 0.0055) and the right medial frontal gyrus ( p = 0.0022) in the DSLE group than in the non-DSLE group. Conclusion Hypometabolism in the medial frontal gyrus may be related to major depressive disorder in SLE. Larger studies are needed to clarify this relationship.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/j.jns.2017.05.059</identifier><identifier>PMID: 28716225</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Case-Control Studies ; Depression ; Depressive Disorder, Major - complications ; Depressive Disorder, Major - metabolism ; Female ; Fluorodeoxyglucose F18 - metabolism ; Functional Neuroimaging ; Glucose - metabolism ; Humans ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - metabolism ; Major depressive disorder ; Male ; Neurology ; Neuropsychiatric systemic lupus erythematosus ; Positron emission tomography ; Prefrontal Cortex - metabolism ; Systemic lupus erythematosus ; Young Adult</subject><ispartof>Journal of the neurological sciences, 2017-08, Vol.379, p.127-130</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-e067a76927e3c836ab9da2de8d6728ef0affd0911740fb7dba071638769f77af3</citedby><cites>FETCH-LOGICAL-c408t-e067a76927e3c836ab9da2de8d6728ef0affd0911740fb7dba071638769f77af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022510X17303659$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28716225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saito, Tomoyuki</creatorcontrib><creatorcontrib>Tamura, Maasa</creatorcontrib><creatorcontrib>Chiba, Yuhei</creatorcontrib><creatorcontrib>Katsuse, Omi</creatorcontrib><creatorcontrib>Suda, Akira</creatorcontrib><creatorcontrib>Kamada, Ayuko</creatorcontrib><creatorcontrib>Ikura, Takahiro</creatorcontrib><creatorcontrib>Abe, Kie</creatorcontrib><creatorcontrib>Ogawa, Matsuyoshi</creatorcontrib><creatorcontrib>Minegishi, Kaoru</creatorcontrib><creatorcontrib>Yoshimi, Ryusuke</creatorcontrib><creatorcontrib>Kirino, Yohei</creatorcontrib><creatorcontrib>Ihata, Atsushi</creatorcontrib><creatorcontrib>Hirayasu, Yoshio</creatorcontrib><title>Regional cerebral glucose metabolism in systemic lupus erythematosus patients with major depressive disorder</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Abstract Objectives Depression is frequently observed in patients with systemic lupus erythematosus (SLE). Neuropsychiatric SLE (NPSLE) patients often exhibit cerebral hypometabolism, but the association between cerebral metabolism and depression remains unclear. To elucidate the features of cerebral metabolism in SLE patients with depression, we performed brain 18F-fluoro- d -glucose positron emission tomography (FDG-PET) on SLE patients with and without major depressive disorder. Methods We performed brain FDG-PET on 20 SLE subjects (5 male, 15 female). The subjects were divided into two groups: subjects with major depressive disorder (DSLE) and subjects without major depressive disorder (non-DSLE). Cerebral glucose metabolism was analyzed using the three-dimensional stereotactic surface projection (3D-SSP) program. Regional metabolism was evaluated by stereotactic extraction estimation (SEE), in which the whole brain was divided into segments. Results Every SLE subject exhibited cerebral hypometabolism, in contrast to the normal healthy subjects. Regional analysis revealed a significantly lower ER in the left medial frontal gyrus ( p = 0.0055) and the right medial frontal gyrus ( p = 0.0022) in the DSLE group than in the non-DSLE group. Conclusion Hypometabolism in the medial frontal gyrus may be related to major depressive disorder in SLE. Larger studies are needed to clarify this relationship.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Depression</subject><subject>Depressive Disorder, Major - complications</subject><subject>Depressive Disorder, Major - metabolism</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18 - metabolism</subject><subject>Functional Neuroimaging</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Lupus Erythematosus, Systemic - metabolism</subject><subject>Major depressive disorder</subject><subject>Male</subject><subject>Neurology</subject><subject>Neuropsychiatric systemic lupus erythematosus</subject><subject>Positron emission tomography</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Systemic lupus erythematosus</subject><subject>Young Adult</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd2L1TAQxYMo7nX1D_BF8uhLr5N026QIgizrBywIfoBvIU2mu6ltUzPpyv3vzeWuPvggDCQD5xw4v2HsuYC9ANG-GvfjQnsJQu2hKdM9YDuhla4areuHbAcgZdUI-H7GnhCNANBq3T1mZ1Ir0UrZ7Nj0GW9CXOzEHSbsU_ncTJuLhHzGbPs4BZp5WDgdKOMcHJ-2dSOO6ZBvcbY5UtlWmwMumfivkG_5bMeYuMc1IVG4Q-4DxeQxPWWPBjsRPrt_z9m3d1dfLz9U15_ef7x8e125C9C5QmiVVW0nFdZO163tO2-lR-1bJTUOYIfBQyeEuoChV763UOrUulgGpexQn7OXp9w1xZ8bUjZzIIfTZBeMGxnRSSHqQqApUnGSuhSJEg5mTWG26WAEmCNkM5oC2RwhG2jKdMXz4j5-62f0fx1_qBbB65MAS8m7gMmQK3wc-pDQZeNj-G_8m3_cbgpLcHb6gQekMW6p3Ku0MCQNmC_HKx-PLFQNdVsCfgOQYaUB</recordid><startdate>20170815</startdate><enddate>20170815</enddate><creator>Saito, Tomoyuki</creator><creator>Tamura, Maasa</creator><creator>Chiba, Yuhei</creator><creator>Katsuse, Omi</creator><creator>Suda, Akira</creator><creator>Kamada, Ayuko</creator><creator>Ikura, Takahiro</creator><creator>Abe, Kie</creator><creator>Ogawa, Matsuyoshi</creator><creator>Minegishi, Kaoru</creator><creator>Yoshimi, Ryusuke</creator><creator>Kirino, Yohei</creator><creator>Ihata, Atsushi</creator><creator>Hirayasu, Yoshio</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170815</creationdate><title>Regional cerebral glucose metabolism in systemic lupus erythematosus patients with major depressive disorder</title><author>Saito, Tomoyuki ; Tamura, Maasa ; Chiba, Yuhei ; Katsuse, Omi ; Suda, Akira ; Kamada, Ayuko ; Ikura, Takahiro ; Abe, Kie ; Ogawa, Matsuyoshi ; Minegishi, Kaoru ; Yoshimi, Ryusuke ; Kirino, Yohei ; Ihata, Atsushi ; Hirayasu, Yoshio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-e067a76927e3c836ab9da2de8d6728ef0affd0911740fb7dba071638769f77af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Depression</topic><topic>Depressive Disorder, Major - complications</topic><topic>Depressive Disorder, Major - metabolism</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18 - metabolism</topic><topic>Functional Neuroimaging</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Lupus Erythematosus, Systemic - metabolism</topic><topic>Major depressive disorder</topic><topic>Male</topic><topic>Neurology</topic><topic>Neuropsychiatric systemic lupus erythematosus</topic><topic>Positron emission tomography</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Systemic lupus erythematosus</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saito, Tomoyuki</creatorcontrib><creatorcontrib>Tamura, Maasa</creatorcontrib><creatorcontrib>Chiba, Yuhei</creatorcontrib><creatorcontrib>Katsuse, Omi</creatorcontrib><creatorcontrib>Suda, Akira</creatorcontrib><creatorcontrib>Kamada, Ayuko</creatorcontrib><creatorcontrib>Ikura, Takahiro</creatorcontrib><creatorcontrib>Abe, Kie</creatorcontrib><creatorcontrib>Ogawa, Matsuyoshi</creatorcontrib><creatorcontrib>Minegishi, Kaoru</creatorcontrib><creatorcontrib>Yoshimi, Ryusuke</creatorcontrib><creatorcontrib>Kirino, Yohei</creatorcontrib><creatorcontrib>Ihata, Atsushi</creatorcontrib><creatorcontrib>Hirayasu, Yoshio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saito, Tomoyuki</au><au>Tamura, Maasa</au><au>Chiba, Yuhei</au><au>Katsuse, Omi</au><au>Suda, Akira</au><au>Kamada, Ayuko</au><au>Ikura, Takahiro</au><au>Abe, Kie</au><au>Ogawa, Matsuyoshi</au><au>Minegishi, Kaoru</au><au>Yoshimi, Ryusuke</au><au>Kirino, Yohei</au><au>Ihata, Atsushi</au><au>Hirayasu, Yoshio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional cerebral glucose metabolism in systemic lupus erythematosus patients with major depressive disorder</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2017-08-15</date><risdate>2017</risdate><volume>379</volume><spage>127</spage><epage>130</epage><pages>127-130</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><abstract>Abstract Objectives Depression is frequently observed in patients with systemic lupus erythematosus (SLE). Neuropsychiatric SLE (NPSLE) patients often exhibit cerebral hypometabolism, but the association between cerebral metabolism and depression remains unclear. To elucidate the features of cerebral metabolism in SLE patients with depression, we performed brain 18F-fluoro- d -glucose positron emission tomography (FDG-PET) on SLE patients with and without major depressive disorder. Methods We performed brain FDG-PET on 20 SLE subjects (5 male, 15 female). The subjects were divided into two groups: subjects with major depressive disorder (DSLE) and subjects without major depressive disorder (non-DSLE). Cerebral glucose metabolism was analyzed using the three-dimensional stereotactic surface projection (3D-SSP) program. Regional metabolism was evaluated by stereotactic extraction estimation (SEE), in which the whole brain was divided into segments. Results Every SLE subject exhibited cerebral hypometabolism, in contrast to the normal healthy subjects. Regional analysis revealed a significantly lower ER in the left medial frontal gyrus ( p = 0.0055) and the right medial frontal gyrus ( p = 0.0022) in the DSLE group than in the non-DSLE group. Conclusion Hypometabolism in the medial frontal gyrus may be related to major depressive disorder in SLE. Larger studies are needed to clarify this relationship.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28716225</pmid><doi>10.1016/j.jns.2017.05.059</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Case-Control Studies Depression Depressive Disorder, Major - complications Depressive Disorder, Major - metabolism Female Fluorodeoxyglucose F18 - metabolism Functional Neuroimaging Glucose - metabolism Humans Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - metabolism Major depressive disorder Male Neurology Neuropsychiatric systemic lupus erythematosus Positron emission tomography Prefrontal Cortex - metabolism Systemic lupus erythematosus Young Adult |
| title | Regional cerebral glucose metabolism in systemic lupus erythematosus patients with major depressive disorder |
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