Development of a New Immunoassay for Human Cathepsin K-Generated Periostin Fragments as a Serum Biomarker for Cortical Bone

Periostin is a matricellular protein mainly expressed by periosteal cells and osteocytes in bone, but is also present in several other tissues. Available immunoassays use antibodies of unclear specificity. The aim of the study was to develop a bone-specific periostin ELISA based on the detection of...

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Veröffentlicht in:	Calcified tissue international 2017-11, Vol.101 (5), p.501-509
Hauptverfasser:	Garnero, Patrick, Bonnet, Nicolas, Ferrari, Serge L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Biochemistry Biomarkers - blood Biomedical and Life Sciences Bone mineral density Cancellous bone Cathepsin K Cathepsin K - metabolism Cell Adhesion Molecules - chemistry Cell Adhesion Molecules - metabolism Cell Biology Collagen Computed tomography Cortical bone Cortical Bone - chemistry Endocrinology Enzyme-Linked Immunosorbent Assay Female Hip Humans Immunohistochemistry Life Sciences Mice Original Research Orthopedics Osteoclasts Osteocytes Osteoporosis Peptide Fragments - analysis Peptide Fragments - blood Polyclonal antibodies Post-menopause Postmenopause Radius Serum levels Tibia
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