Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats

Systemic administration of a Connexin43 mimetic peptide, Peptide5, has been shown to reduce secondary tissue damage and improve functional recovery after spinal cord injury (SCI). This study investigated safety measures and potential off-target effects of Peptide5 systemic administration. Rats were...

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Veröffentlicht in:	Experimental brain research 2017-10, Vol.235 (10), p.3033-3048
Hauptverfasser:	Mao, Yilin, Nguyen, Tara, Tonkin, Ryan S., Lees, Justin G., Warren, Caitlyn, O’Carroll, Simon J., Nicholson, Louise F. B., Green, Colin R., Moalem-Taylor, Gila, Gorrie, Catherine A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes Biomedical and Life Sciences Biomedicine Care and treatment Chemokines Connexin 43 Connexins Cytokines Growth factors Health aspects Injury analysis Neurology Neurosciences Oligodendrocytes Peptides Physiological aspects Plasma levels Rats Recovery of function Research Article Rodents Safety measures Spinal cord Spinal cord injuries
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