IL-7 Restores T Lymphocyte Immunometabolic Failure in Septic Shock Patients through mTOR Activation

T lymphocyte alterations are central to sepsis pathophysiology, whereas related mechanisms remain poorly understood. We hypothesized that metabolic alterations could play a role in sepsis-induced T lymphocyte dysfunction. Samples from septic shock patients were obtained at day 3 and compared with th...

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Veröffentlicht in:	The Journal of immunology (1950) 2017-09, Vol.199 (5), p.1606-1615
Hauptverfasser:	Venet, Fabienne, Demaret, Julie, Blaise, Benjamin J, Rouget, Christelle, Girardot, Thibaut, Idealisoa, Estellie, Rimmelé, Thomas, Mallet, François, Lepape, Alain, Textoris, Julien, Monneret, Guillaume
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Aged Aged, 80 and over AKT protein ATP Cell activation Cell Proliferation - drug effects Cells, Cultured Energy Metabolism - drug effects Female Glucose Glucose - metabolism Glucose Transporter Type 1 - genetics Glucose Transporter Type 1 - metabolism Glycolysis Glycolysis - drug effects Humans Immunotherapy - methods Interleukin 7 Interleukin-7 - immunology Interleukin-7 - therapeutic use Lymphocytes Lymphocytes T Magnetic resonance spectroscopy Male Metabolism Middle Aged NMR Nuclear magnetic resonance Nuclear Magnetic Resonance, Biomolecular Oxidative phosphorylation Oxidative Phosphorylation - drug effects Phosphorylation Rapamycin Sepsis Septic shock Shock, Septic - immunology Shock, Septic - therapy Sirolimus - pharmacology Spectroscopy Stimulation T-Lymphocytes - immunology T-Lymphocytes - metabolism TOR protein TOR Serine-Threonine Kinases - metabolism
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