Structuring of the 3′ Splice Site by U2AF65

Recognition of the 3′ splice site in mammalian introns is accomplished by association of the splicing factor U2AF with the precursor mRNA (pre-mRNA) in a multiprotein splicing commitment complex. It is well established that this interaction involves binding of the large U2AF65 subunit to sequences u...

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Veröffentlicht in:	The Journal of biological chemistry 2003-12, Vol.278 (50), p.50572-50577
Hauptverfasser:	Kent, Oliver A., Reayi, Ayube, Foong, Louise, Chilibeck, Kaari A., MacMillan, Andrew M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Crystallography, X-Ray DNA, Complementary - metabolism Edetic Acid - pharmacology Escherichia coli - metabolism Gene Deletion Models, Biological Models, Chemical Models, Molecular Mutation Nuclear Proteins Protein Binding Protein Conformation Protein Structure, Secondary Protein Structure, Tertiary Ribonucleoproteins - chemistry Ribonucleoproteins - genetics RNA - metabolism RNA Splicing RNA, Messenger - metabolism Spliceosomes - metabolism Splicing Factor U2AF U2AF65 protein
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