Temporal aspects of spatial task performance during intermittent hypoxia in the rat: evidence for neurogenesis
Intermittent hypoxia (IH) during sleep, such as occurs in obstructive sleep apnea, leads to degenerative changes in the hippocampus, and is associated with spatial learning deficits in the adult rat. We report that in Sprague–Dawley rats the initial IH‐induced impairments in spatial learning are fol...
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| Veröffentlicht in: | The European journal of neuroscience 2003-10, Vol.18 (8), p.2335-2342 |
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| container_title | The European journal of neuroscience |
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| creator | Gozal, David Row, Barry W. Gozal, Evelyne Kheirandish, Leila Neville, Jennifer J. Brittian, Kenneth R. Sachleben Jr, Leroy R. Guo, Shang Z. |
| description | Intermittent hypoxia (IH) during sleep, such as occurs in obstructive sleep apnea, leads to degenerative changes in the hippocampus, and is associated with spatial learning deficits in the adult rat. We report that in Sprague–Dawley rats the initial IH‐induced impairments in spatial learning are followed by a partial functional recovery over time, despite continuing IH exposure. These functional changes coincide with initial decreases in basal neurogenesis as shown by the number of positively colabelled cells for BrdU and neurofilament in the dentate gyrus of the hippocampus, and are followed by increased expression of neuronal progenitors and mature neurons (nestin and BrdU‐neurofilament positively labelled cells, respectively). In contrast, no changes occurred during the course of IH exposures in the expression of the synaptic proteins synaptophysin, SNAP25, and drebrin. Collectively, these findings indicate that the occurrence of IH during the lights on period results in a biphasic pattern of neurogenesis in the hippocampus of adult rats, and may account for the observed partial recovery of spatial function. |
| doi_str_mv | 10.1046/j.1460-9568.2003.02947.x |
| format | Article |
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We report that in Sprague–Dawley rats the initial IH‐induced impairments in spatial learning are followed by a partial functional recovery over time, despite continuing IH exposure. These functional changes coincide with initial decreases in basal neurogenesis as shown by the number of positively colabelled cells for BrdU and neurofilament in the dentate gyrus of the hippocampus, and are followed by increased expression of neuronal progenitors and mature neurons (nestin and BrdU‐neurofilament positively labelled cells, respectively). In contrast, no changes occurred during the course of IH exposures in the expression of the synaptic proteins synaptophysin, SNAP25, and drebrin. 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We report that in Sprague–Dawley rats the initial IH‐induced impairments in spatial learning are followed by a partial functional recovery over time, despite continuing IH exposure. These functional changes coincide with initial decreases in basal neurogenesis as shown by the number of positively colabelled cells for BrdU and neurofilament in the dentate gyrus of the hippocampus, and are followed by increased expression of neuronal progenitors and mature neurons (nestin and BrdU‐neurofilament positively labelled cells, respectively). In contrast, no changes occurred during the course of IH exposures in the expression of the synaptic proteins synaptophysin, SNAP25, and drebrin. Collectively, these findings indicate that the occurrence of IH during the lights on period results in a biphasic pattern of neurogenesis in the hippocampus of adult rats, and may account for the observed partial recovery of spatial function.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Blotting, Western</subject><subject>Bromodeoxyuridine - metabolism</subject><subject>Cues</subject><subject>drebrin</subject><subject>Escape Reaction</subject><subject>Hippocampus - metabolism</subject><subject>Hippocampus - pathology</subject><subject>Hypoxia - physiopathology</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Maze Learning</subject><subject>Neurons - metabolism</subject><subject>Oxygen - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reaction Time</subject><subject>Recovery of Function</subject><subject>SNAP25</subject><subject>Spatial Behavior - physiology</subject><subject>spatial learning</subject><subject>synaptic plasticity</subject><subject>synaptophysin</subject><subject>Time Factors</subject><issn>0953-816X</issn><issn>1460-9568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi0EosvCX0A-cUsYx4mdIHFAVT-ApUioqNysaTJpvc0XtgO7_x6HXZUrJ49n3mdGehjjAlIBuXq7TUWuIKkKVaYZgEwhq3Kd7p6w1ePgKVtBVcikFOrHCXvh_RYASpUXz9lJDGWZqIoVG66pn0aHHUc_UR08H1vuJww2tgL6Bz6Ra0fX41ATb2Znhztuh0CutyHQEPj9fhp3FmOTh3viDsM7Tr9sQwsQST7Q7MY7Gshb_5I9a7Hz9Or4rtn387Pr08tk8_Xi4-mHTVLnIHXSYqErDSKTWigtUIESWIsabwHLpmo0KCxLKrXOq7yARsRv1tZUKtSYKSnX7M1h7-TGnzP5YHrra-o6HGicvRFVFuVEc2tWHoK1G7131JrJ2R7d3ggwi2uzNYtSsyg1i2vz17XZRfT18cZ821PzDzzKjYH3h8Bv29H-vxebs09XSxX55MBbH2j3yKN7MEpLXZibqwsD8tuX883nG3Mp_wDBop3_</recordid><startdate>200310</startdate><enddate>200310</enddate><creator>Gozal, David</creator><creator>Row, Barry W.</creator><creator>Gozal, Evelyne</creator><creator>Kheirandish, Leila</creator><creator>Neville, Jennifer J.</creator><creator>Brittian, Kenneth R.</creator><creator>Sachleben Jr, Leroy R.</creator><creator>Guo, Shang Z.</creator><general>Blackwell Science, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope></search><sort><creationdate>200310</creationdate><title>Temporal aspects of spatial task performance during intermittent hypoxia in the rat: evidence for neurogenesis</title><author>Gozal, David ; Row, Barry W. ; Gozal, Evelyne ; Kheirandish, Leila ; Neville, Jennifer J. ; Brittian, Kenneth R. ; Sachleben Jr, Leroy R. ; Guo, Shang Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4037-fa5797012371671a6061ac1cab0a8d9d706a88e87749450d16a82fce86a7a2633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Blotting, Western</topic><topic>Bromodeoxyuridine - metabolism</topic><topic>Cues</topic><topic>drebrin</topic><topic>Escape Reaction</topic><topic>Hippocampus - metabolism</topic><topic>Hippocampus - pathology</topic><topic>Hypoxia - physiopathology</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Maze Learning</topic><topic>Neurons - metabolism</topic><topic>Oxygen - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reaction Time</topic><topic>Recovery of Function</topic><topic>SNAP25</topic><topic>Spatial Behavior - physiology</topic><topic>spatial learning</topic><topic>synaptic plasticity</topic><topic>synaptophysin</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gozal, David</creatorcontrib><creatorcontrib>Row, Barry W.</creatorcontrib><creatorcontrib>Gozal, Evelyne</creatorcontrib><creatorcontrib>Kheirandish, Leila</creatorcontrib><creatorcontrib>Neville, Jennifer J.</creatorcontrib><creatorcontrib>Brittian, Kenneth R.</creatorcontrib><creatorcontrib>Sachleben Jr, Leroy R.</creatorcontrib><creatorcontrib>Guo, Shang Z.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><jtitle>The European journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gozal, David</au><au>Row, Barry W.</au><au>Gozal, Evelyne</au><au>Kheirandish, Leila</au><au>Neville, Jennifer J.</au><au>Brittian, Kenneth R.</au><au>Sachleben Jr, Leroy R.</au><au>Guo, Shang Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temporal aspects of spatial task performance during intermittent hypoxia in the rat: evidence for neurogenesis</atitle><jtitle>The European journal of neuroscience</jtitle><addtitle>Eur J Neurosci</addtitle><date>2003-10</date><risdate>2003</risdate><volume>18</volume><issue>8</issue><spage>2335</spage><epage>2342</epage><pages>2335-2342</pages><issn>0953-816X</issn><eissn>1460-9568</eissn><abstract>Intermittent hypoxia (IH) during sleep, such as occurs in obstructive sleep apnea, leads to degenerative changes in the hippocampus, and is associated with spatial learning deficits in the adult rat. We report that in Sprague–Dawley rats the initial IH‐induced impairments in spatial learning are followed by a partial functional recovery over time, despite continuing IH exposure. These functional changes coincide with initial decreases in basal neurogenesis as shown by the number of positively colabelled cells for BrdU and neurofilament in the dentate gyrus of the hippocampus, and are followed by increased expression of neuronal progenitors and mature neurons (nestin and BrdU‐neurofilament positively labelled cells, respectively). In contrast, no changes occurred during the course of IH exposures in the expression of the synaptic proteins synaptophysin, SNAP25, and drebrin. 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| subjects | Animals Apoptosis Blotting, Western Bromodeoxyuridine - metabolism Cues drebrin Escape Reaction Hippocampus - metabolism Hippocampus - pathology Hypoxia - physiopathology Immunohistochemistry Male Maze Learning Neurons - metabolism Oxygen - metabolism Rats Rats, Sprague-Dawley Reaction Time Recovery of Function SNAP25 Spatial Behavior - physiology spatial learning synaptic plasticity synaptophysin Time Factors |
| title | Temporal aspects of spatial task performance during intermittent hypoxia in the rat: evidence for neurogenesis |
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