Sensitivity of the FPG protein towards alkylation damage in the comet assay

The comet assay (single cell gel electrophoresis) is widely used for the evaluation of DNA-damaging effects in genotoxicity testing and population monitoring. In its standard version at pH >13, DNA double strand breaks (DSB), DNA single strand breaks (SSB) and alkali-labile sites (ALS) lead to in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicology letters 2004-01, Vol.146 (2), p.151-158
Hauptverfasser:	Speit, Günter, Schütz, Petra, Bonzheim, Irina, Trenz, Kristina, Hoffmann, Heike
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating agents Alkylation Animals Biological and medical sciences Cells, Cultured Comet assay Comet Assay - methods Cricetinae DNA Damage DNA-Formamidopyrimidine Glycosylase - pharmacology formamidopyrimidine glycosylase FPG protein Human blood cells Humans Hydrogen peroxide Hydrogen-Ion Concentration Medical sciences Oxidation-Reduction pH value Sensitivity and Specificity Toxicology V79 cells
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!