PSMB8 as a Candidate Marker of Responsiveness to Preoperative Radiation Therapy in Rectal Cancer Patients

The ability to predict individual responsiveness to cancer therapy is urgently needed. This is particularly true for patients with locally advanced rectal cancer (LARC) because a large proportion are resistant to preoperative chemoradiation therapy (CRT). In this study, we sought to identify markers...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2017-08, Vol.98 (5), p.1164-1173
Hauptverfasser:	Ha, Ye Jin, Tak, Ka Hee, Kim, Chan Wook, Roh, Seon Ae, Choi, Eun Kyung, Cho, Dong Hyung, Kim, Jeong Hwan, Kim, Seon Kyu, Kim, Seon Young, Kim, Yong Sung, Kim, Jin Cheon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Caspase 3 - genetics Caspase 3 - metabolism Cation Transport Proteins - genetics Cation Transport Proteins - metabolism Cell Death Cell Line, Tumor Gene Expression Profiling - methods Gene Knockdown Techniques Gene Silencing Genetic Markers Heterografts Humans Male Mice Mice, Inbred BALB C Mice, Nude Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Preoperative Care - methods Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Radiation Tolerance - genetics Real-Time Polymerase Chain Reaction Rectal Neoplasms - genetics Rectal Neoplasms - pathology Rectal Neoplasms - radiotherapy Rectal Neoplasms - surgery Sequence Analysis, RNA - methods Tumor Stem Cell Assay Up-Regulation
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