Effect of Serial Use of Bone Morphogenetic Protein 2 and Fibroblast Growth Factor 2 on Periodontal Tissue Regeneration
This study evaluates the synergistic effect of serial application of bone morphogenetic protein 2 (BMP2) and fibroblast growth factor 2 (FGF2) on both new bone formation and periodontal tissue regeneration using 1-wall intrabony defect in mongrel dogs. One-wall defects were created at the mesial asp...
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| Veröffentlicht in: | Implant dentistry 2017-10, Vol.26 (5), p.664-673 |
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| container_issue | 5 |
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| container_title | Implant dentistry |
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| creator | Lee, Ah-Reum Choi, Hyunmin Kim, Jee-Hwan Cho, Sung-Won Park, Young-Bum |
| description | This study evaluates the synergistic effect of serial application of bone morphogenetic protein 2 (BMP2) and fibroblast growth factor 2 (FGF2) on both new bone formation and periodontal tissue regeneration using 1-wall intrabony defect in mongrel dogs.
One-wall defects were created at the mesial aspect of the mandibular first molars of 6 male mongrel dogs. Each mandibular defect received 1 of the 2 experimental treatments randomly (BMP2 or BMP2 + FGF2), and it was allowed to heal for either 4 or 8 weeks postoperatively. Histologic and histomorphometric analyses were performed for the evaluation of the overall healing patterns of new bone formation and periodontal tissue regeneration.
The results showed that after 8 weeks, serial application of BMP2 and FGF2 significantly improved the periodontal tissue regeneration, whereas application of BMP2 only showed greater new bone formation after 4 weeks.
The serial application of BMP2 and FGF2 may have synergistic effects on periodontal tissue regeneration over time. |
| doi_str_mv | 10.1097/ID.0000000000000624 |
| format | Article |
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One-wall defects were created at the mesial aspect of the mandibular first molars of 6 male mongrel dogs. Each mandibular defect received 1 of the 2 experimental treatments randomly (BMP2 or BMP2 + FGF2), and it was allowed to heal for either 4 or 8 weeks postoperatively. Histologic and histomorphometric analyses were performed for the evaluation of the overall healing patterns of new bone formation and periodontal tissue regeneration.
The results showed that after 8 weeks, serial application of BMP2 and FGF2 significantly improved the periodontal tissue regeneration, whereas application of BMP2 only showed greater new bone formation after 4 weeks.
The serial application of BMP2 and FGF2 may have synergistic effects on periodontal tissue regeneration over time.</description><identifier>ISSN: 1056-6163</identifier><identifier>EISSN: 1538-2982</identifier><identifier>DOI: 10.1097/ID.0000000000000624</identifier><identifier>PMID: 28719568</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Bone Morphogenetic Protein 2 - administration & dosage ; Bone Morphogenetic Protein 2 - therapeutic use ; Bone Regeneration - drug effects ; Dentistry ; Dogs ; Drug Synergism ; Fibroblast Growth Factor 2 - administration & dosage ; Fibroblast Growth Factor 2 - therapeutic use ; Guided Tissue Regeneration, Periodontal - methods ; Male ; Mandible - diagnostic imaging ; Mandible - pathology ; Periodontium - diagnostic imaging ; Periodontium - pathology ; X-Ray Microtomography</subject><ispartof>Implant dentistry, 2017-10, Vol.26 (5), p.664-673</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-3fcd860df28546d4c6eb13706b5a968f047edfa530121bb3deaf011cb21b8223</citedby><cites>FETCH-LOGICAL-c371t-3fcd860df28546d4c6eb13706b5a968f047edfa530121bb3deaf011cb21b8223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28719568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Ah-Reum</creatorcontrib><creatorcontrib>Choi, Hyunmin</creatorcontrib><creatorcontrib>Kim, Jee-Hwan</creatorcontrib><creatorcontrib>Cho, Sung-Won</creatorcontrib><creatorcontrib>Park, Young-Bum</creatorcontrib><title>Effect of Serial Use of Bone Morphogenetic Protein 2 and Fibroblast Growth Factor 2 on Periodontal Tissue Regeneration</title><title>Implant dentistry</title><addtitle>Implant Dent</addtitle><description>This study evaluates the synergistic effect of serial application of bone morphogenetic protein 2 (BMP2) and fibroblast growth factor 2 (FGF2) on both new bone formation and periodontal tissue regeneration using 1-wall intrabony defect in mongrel dogs.
One-wall defects were created at the mesial aspect of the mandibular first molars of 6 male mongrel dogs. Each mandibular defect received 1 of the 2 experimental treatments randomly (BMP2 or BMP2 + FGF2), and it was allowed to heal for either 4 or 8 weeks postoperatively. Histologic and histomorphometric analyses were performed for the evaluation of the overall healing patterns of new bone formation and periodontal tissue regeneration.
The results showed that after 8 weeks, serial application of BMP2 and FGF2 significantly improved the periodontal tissue regeneration, whereas application of BMP2 only showed greater new bone formation after 4 weeks.
The serial application of BMP2 and FGF2 may have synergistic effects on periodontal tissue regeneration over time.</description><subject>Animals</subject><subject>Bone Morphogenetic Protein 2 - administration & dosage</subject><subject>Bone Morphogenetic Protein 2 - therapeutic use</subject><subject>Bone Regeneration - drug effects</subject><subject>Dentistry</subject><subject>Dogs</subject><subject>Drug Synergism</subject><subject>Fibroblast Growth Factor 2 - administration & dosage</subject><subject>Fibroblast Growth Factor 2 - therapeutic use</subject><subject>Guided Tissue Regeneration, Periodontal - methods</subject><subject>Male</subject><subject>Mandible - diagnostic imaging</subject><subject>Mandible - pathology</subject><subject>Periodontium - diagnostic imaging</subject><subject>Periodontium - pathology</subject><subject>X-Ray Microtomography</subject><issn>1056-6163</issn><issn>1538-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUMtOwzAQtBCIlsIXICEfuaT4kTjOEfqiUhEVlHPkOGsalMbFdkD8PalaEGL3sDvamVlpELqkZEhJlt7Mx0PytwSLj1CfJlxGLJPsuNtJIiJBBe-hM-_fCGFdy1PUYzKlWSJkH31MjAEdsDX4GVylavziYYfubAP4wbrt2r5CA6HSeOlsgKrBDKumxNOqcLaolQ945uxnWOOp0sG67mwbvOzMbGmb0DmuKu9bwE-wM3IqVLY5RydG1R4uDnOAVtPJanQfLR5n89HtItI8pSHiRpdSkNIwmcSijLWAgvKUiCJRmZCGxCmURiWcUEaLgpegDKFUFx2SjPEBut7bbp19b8GHfFN5DXWtGrCtz2nGCM-oSLKOyvdU7az3Dky-ddVGua-cknyXdz4f5__z7lRXhwdtsYHyV_MTMP8GxXd6-g</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Lee, Ah-Reum</creator><creator>Choi, Hyunmin</creator><creator>Kim, Jee-Hwan</creator><creator>Cho, Sung-Won</creator><creator>Park, Young-Bum</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201710</creationdate><title>Effect of Serial Use of Bone Morphogenetic Protein 2 and Fibroblast Growth Factor 2 on Periodontal Tissue Regeneration</title><author>Lee, Ah-Reum ; Choi, Hyunmin ; Kim, Jee-Hwan ; Cho, Sung-Won ; Park, Young-Bum</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-3fcd860df28546d4c6eb13706b5a968f047edfa530121bb3deaf011cb21b8223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Bone Morphogenetic Protein 2 - administration & dosage</topic><topic>Bone Morphogenetic Protein 2 - therapeutic use</topic><topic>Bone Regeneration - drug effects</topic><topic>Dentistry</topic><topic>Dogs</topic><topic>Drug Synergism</topic><topic>Fibroblast Growth Factor 2 - administration & dosage</topic><topic>Fibroblast Growth Factor 2 - therapeutic use</topic><topic>Guided Tissue Regeneration, Periodontal - methods</topic><topic>Male</topic><topic>Mandible - diagnostic imaging</topic><topic>Mandible - pathology</topic><topic>Periodontium - diagnostic imaging</topic><topic>Periodontium - pathology</topic><topic>X-Ray Microtomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Ah-Reum</creatorcontrib><creatorcontrib>Choi, Hyunmin</creatorcontrib><creatorcontrib>Kim, Jee-Hwan</creatorcontrib><creatorcontrib>Cho, Sung-Won</creatorcontrib><creatorcontrib>Park, Young-Bum</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Implant dentistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Ah-Reum</au><au>Choi, Hyunmin</au><au>Kim, Jee-Hwan</au><au>Cho, Sung-Won</au><au>Park, Young-Bum</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Serial Use of Bone Morphogenetic Protein 2 and Fibroblast Growth Factor 2 on Periodontal Tissue Regeneration</atitle><jtitle>Implant dentistry</jtitle><addtitle>Implant Dent</addtitle><date>2017-10</date><risdate>2017</risdate><volume>26</volume><issue>5</issue><spage>664</spage><epage>673</epage><pages>664-673</pages><issn>1056-6163</issn><eissn>1538-2982</eissn><abstract>This study evaluates the synergistic effect of serial application of bone morphogenetic protein 2 (BMP2) and fibroblast growth factor 2 (FGF2) on both new bone formation and periodontal tissue regeneration using 1-wall intrabony defect in mongrel dogs.
One-wall defects were created at the mesial aspect of the mandibular first molars of 6 male mongrel dogs. Each mandibular defect received 1 of the 2 experimental treatments randomly (BMP2 or BMP2 + FGF2), and it was allowed to heal for either 4 or 8 weeks postoperatively. Histologic and histomorphometric analyses were performed for the evaluation of the overall healing patterns of new bone formation and periodontal tissue regeneration.
The results showed that after 8 weeks, serial application of BMP2 and FGF2 significantly improved the periodontal tissue regeneration, whereas application of BMP2 only showed greater new bone formation after 4 weeks.
The serial application of BMP2 and FGF2 may have synergistic effects on periodontal tissue regeneration over time.</abstract><cop>United States</cop><pmid>28719568</pmid><doi>10.1097/ID.0000000000000624</doi><tpages>10</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; EZB Electronic Journals Library |
| subjects | Animals Bone Morphogenetic Protein 2 - administration & dosage Bone Morphogenetic Protein 2 - therapeutic use Bone Regeneration - drug effects Dentistry Dogs Drug Synergism Fibroblast Growth Factor 2 - administration & dosage Fibroblast Growth Factor 2 - therapeutic use Guided Tissue Regeneration, Periodontal - methods Male Mandible - diagnostic imaging Mandible - pathology Periodontium - diagnostic imaging Periodontium - pathology X-Ray Microtomography |
| title | Effect of Serial Use of Bone Morphogenetic Protein 2 and Fibroblast Growth Factor 2 on Periodontal Tissue Regeneration |
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