Structural Features of Europium(II)‐Containing Cryptates That Influence Relaxivity
EuII‐containing complexes were studied with respect to properties relevant to their use as contrast agents for magnetic resonance imaging. The influences of molecular parameters and field strength on relaxivity were studied for a series of EuII‐containing cryptates and their adducts with β‐cyclodext...
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| Veröffentlicht in: | Chemistry : a European journal 2017-11, Vol.23 (61), p.15404-15414 |
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| container_issue | 61 |
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| container_title | Chemistry : a European journal |
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| creator | Lenora, Chamika U. Carniato, Fabio Shen, Yimin Latif, Zahid Haacke, E. Mark Martin, Philip D. Botta, Mauro Allen, Matthew J. |
| description | EuII‐containing complexes were studied with respect to properties relevant to their use as contrast agents for magnetic resonance imaging. The influences of molecular parameters and field strength on relaxivity were studied for a series of EuII‐containing cryptates and their adducts with β‐cyclodextrins, poly‐β‐cyclodextrins, and human serum albumin. Solid‐ and solution‐phase characterization of EuII‐containing complexes is presented that demonstrates the presence of inner‐sphere molecules of water. Additionally, relaxivity, water‐exchange rate, rotational correlation time, and electronic relaxation times were determined using variable‐temperature 17O NMR, nuclear magnetic relaxation dispersion, and electron paramagnetic resonance spectroscopic techniques. These results are expected to be instrumental in the design of future EuII‐based contrast agents.
Agents from the crypt: EuII‐containing cryptates were studied as contrast agents. The relationship between relaxivity, field strength, and molecular parameters for EuII‐containing cryptates are discussed using Solomon–Bloembergen–Morgan theory (see figure). |
| doi_str_mv | 10.1002/chem.201702158 |
| format | Article |
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Agents from the crypt: EuII‐containing cryptates were studied as contrast agents. The relationship between relaxivity, field strength, and molecular parameters for EuII‐containing cryptates are discussed using Solomon–Bloembergen–Morgan theory (see figure).</description><identifier>ISSN: 0947-6539</identifier><identifier>EISSN: 1521-3765</identifier><identifier>DOI: 10.1002/chem.201702158</identifier><identifier>PMID: 28707809</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Adducts ; Chemistry ; Contrast agents ; cryptands ; Cyclodextrins ; Electron paramagnetic resonance ; Europium ; Field strength ; Human serum albumin ; lanthanides ; Magnetic induction ; Magnetic properties ; Magnetic relaxation ; Magnetic resonance imaging ; Resonance ; Serum albumin</subject><ispartof>Chemistry : a European journal, 2017-11, Vol.23 (61), p.15404-15414</ispartof><rights>2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4508-39d7ac0af16dd33fe30972d0b7582d9c29b37e5fe231105f5e42b9895765222f3</citedby><cites>FETCH-LOGICAL-c4508-39d7ac0af16dd33fe30972d0b7582d9c29b37e5fe231105f5e42b9895765222f3</cites><orcidid>0000-0003-4192-355X ; 0000-0002-6868-8759</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fchem.201702158$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fchem.201702158$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28707809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lenora, Chamika U.</creatorcontrib><creatorcontrib>Carniato, Fabio</creatorcontrib><creatorcontrib>Shen, Yimin</creatorcontrib><creatorcontrib>Latif, Zahid</creatorcontrib><creatorcontrib>Haacke, E. Mark</creatorcontrib><creatorcontrib>Martin, Philip D.</creatorcontrib><creatorcontrib>Botta, Mauro</creatorcontrib><creatorcontrib>Allen, Matthew J.</creatorcontrib><title>Structural Features of Europium(II)‐Containing Cryptates That Influence Relaxivity</title><title>Chemistry : a European journal</title><addtitle>Chemistry</addtitle><description>EuII‐containing complexes were studied with respect to properties relevant to their use as contrast agents for magnetic resonance imaging. The influences of molecular parameters and field strength on relaxivity were studied for a series of EuII‐containing cryptates and their adducts with β‐cyclodextrins, poly‐β‐cyclodextrins, and human serum albumin. Solid‐ and solution‐phase characterization of EuII‐containing complexes is presented that demonstrates the presence of inner‐sphere molecules of water. Additionally, relaxivity, water‐exchange rate, rotational correlation time, and electronic relaxation times were determined using variable‐temperature 17O NMR, nuclear magnetic relaxation dispersion, and electron paramagnetic resonance spectroscopic techniques. These results are expected to be instrumental in the design of future EuII‐based contrast agents.
Agents from the crypt: EuII‐containing cryptates were studied as contrast agents. The relationship between relaxivity, field strength, and molecular parameters for EuII‐containing cryptates are discussed using Solomon–Bloembergen–Morgan theory (see figure).</description><subject>Adducts</subject><subject>Chemistry</subject><subject>Contrast agents</subject><subject>cryptands</subject><subject>Cyclodextrins</subject><subject>Electron paramagnetic resonance</subject><subject>Europium</subject><subject>Field strength</subject><subject>Human serum albumin</subject><subject>lanthanides</subject><subject>Magnetic induction</subject><subject>Magnetic properties</subject><subject>Magnetic relaxation</subject><subject>Magnetic resonance imaging</subject><subject>Resonance</subject><subject>Serum albumin</subject><issn>0947-6539</issn><issn>1521-3765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqF0M9O3DAQBnALFcFCufZYReoFDlnG43UcH6togZVASHQ5R95kXILyZ2vHLXvjEXhGngSjBSr10pPn8JtP44-xLxymHABPqzvqpghcAXKZ77AJl8hToTL5iU1Az1SaSaH32YH39wCgMyH22D7mClQOesKWP0YXqjE40yZnZOJAPhlsMg9uWDehO14sTp4fn4qhH03TN_3PpHCb9WjGyJZ3ZkwWvW0D9RUlN9Sah-Z3M24-s11rWk9Hb-8huz2bL4uL9PL6fFF8v0yrmYQ8FbpWpgJjeVbXQlgSoBXWsFIyx1pXqFdCkbSEgnOQVtIMVzrXMv4OEa04ZMfb3LUbfgXyY9k1vqK2NT0NwZdcIyDMAHWk3_6h90NwfbwuKplnXOeooppuVeUG7x3Zcu2azrhNyaF87bt87bv86DsufH2LDauO6g_-XnAEegv-NC1t_hNXFhfzq7_hL0ofjDE</recordid><startdate>20171102</startdate><enddate>20171102</enddate><creator>Lenora, Chamika U.</creator><creator>Carniato, Fabio</creator><creator>Shen, Yimin</creator><creator>Latif, Zahid</creator><creator>Haacke, E. Mark</creator><creator>Martin, Philip D.</creator><creator>Botta, Mauro</creator><creator>Allen, Matthew J.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4192-355X</orcidid><orcidid>https://orcid.org/0000-0002-6868-8759</orcidid></search><sort><creationdate>20171102</creationdate><title>Structural Features of Europium(II)‐Containing Cryptates That Influence Relaxivity</title><author>Lenora, Chamika U. ; Carniato, Fabio ; Shen, Yimin ; Latif, Zahid ; Haacke, E. 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Solid‐ and solution‐phase characterization of EuII‐containing complexes is presented that demonstrates the presence of inner‐sphere molecules of water. Additionally, relaxivity, water‐exchange rate, rotational correlation time, and electronic relaxation times were determined using variable‐temperature 17O NMR, nuclear magnetic relaxation dispersion, and electron paramagnetic resonance spectroscopic techniques. These results are expected to be instrumental in the design of future EuII‐based contrast agents.
Agents from the crypt: EuII‐containing cryptates were studied as contrast agents. The relationship between relaxivity, field strength, and molecular parameters for EuII‐containing cryptates are discussed using Solomon–Bloembergen–Morgan theory (see figure).</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28707809</pmid><doi>10.1002/chem.201702158</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-4192-355X</orcidid><orcidid>https://orcid.org/0000-0002-6868-8759</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adducts Chemistry Contrast agents cryptands Cyclodextrins Electron paramagnetic resonance Europium Field strength Human serum albumin lanthanides Magnetic induction Magnetic properties Magnetic relaxation Magnetic resonance imaging Resonance Serum albumin |
| title | Structural Features of Europium(II)‐Containing Cryptates That Influence Relaxivity |
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