Mechanism of Initiation, Association, and Formation of Amyloid Fibrils Modeled with the N‑Terminal Peptide Fragment, IKYLEFIS, of Myoglobin G‑Helix

Some peptides and proteins undergo self-aggregation under certain conditions, leading to amyloid fibrils formation, which is related to many disease conditions. It is important to understand such amyloid fibrils formation to provide mechanistic detail that governs the process. A predominantly α-heli...

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Veröffentlicht in:	The journal of physical chemistry. B 2017-08, Vol.121 (32), p.7536-7549
Hauptverfasser:	Patel, Sunita, Sasidhar, Yellamraju U, Chary, Kandala V. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amyloid - chemistry Amyloid beta-Peptides - chemistry Hydrogen Bonding Molecular Dynamics Simulation Myoglobin - chemistry Protein Conformation Protein Structure, Secondary Temperature Thermodynamics
Online-Zugang:	Volltext
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