Treatment strategies for rectal cancer with synchronous liver metastases: surgical and oncological outcomes with propensity-score analysis
Background The optimal sequence of surgery for rectal cancer (RC) with synchronous liver metastases (SLM) is controversial. Objectives The primary objective was to explore differences between the rectum first (RF) and the liver first strategy (LF) to achieve the complete resection (CR) of both tumor...
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| Veröffentlicht in: | Clinical & translational oncology 2018-02, Vol.20 (2), p.221-229 |
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| creator | Salvador-Rosés, H. López-Ben, S. Planellas, P. Canals, E. Casellas-Robert, M. Farrés, R. Ramos, E. Codina-Cazador, A. Figueras, J. |
| description | Background
The optimal sequence of surgery for rectal cancer (RC) with synchronous liver metastases (SLM) is controversial.
Objectives
The primary objective was to explore differences between the rectum first (RF) and the liver first strategy (LF) to achieve the complete resection (CR) of both tumors.
Methods
Patients diagnosed of RC with resectable or potentially resectable SLM were included. Data collected prospectively were analyzed with an intention-to-treat perspective, adjusting for between-sample differences (propensity score). The complete resection rate (CRR) was the main outcome variable.
Results
During a 5-year period, 23 patients underwent the LF strategy and 24 patients the RF strategy. Median overall survival (OS) was 32 months in the LF group and 41 months in the RF group (
p
= 0.499), and was 51 and 17 months, respectively, for patients achieving or not achieving CR of both tumors (
p
|
| doi_str_mv | 10.1007/s12094-017-1712-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1920201380</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1920201380</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-c426e15bf245aedfa4f1488602baf81ee8031b0696842e2912031792d456072a3</originalsourceid><addsrcrecordid>eNp9kctqHDEQRUWIiZ1xPiCboGU2nVSp1S_vgvELDNnY4J3QaKrHbbqlsUodM7-Qr7acnmQZEEhVuvcg1RXiM8I3BGi-MyrodAHYFNigKvQ7cYJ11xUlVNX7wxl0-3AsPjI_Qe7WiB_EsWobaKCsT8Tvu0g2TeST5BRtou1ALPsQZSSX7Cid9Y6ifBnSo-S9d48x-DCzHIdfuT1RspwX8ZnkOW4Hly3Wb2TwLoxhqcOcXJgy9g9kF8OOPA9pX7ALkbLcjnse-FQc9XZk-nTYV-L-8uLu_Lq4_Xl1c_7jtnCl1qlwWtWE1bpXurK06a3uUbdtDWpt-xaJWihxDXVXt1qR6vKMSmw6tdFVDY2y5Up8Xbj5Jc8zcTLTwI7G0XrKPzPYKVCAZeasBC5SFwNzpN7s4jDZuDcI5i0Cs0RgcgTmLQKjs-fLAT-vJ9r8c_ydeRaoRcD5ym8pmqcwxzwE_g_1FYtrlJw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1920201380</pqid></control><display><type>article</type><title>Treatment strategies for rectal cancer with synchronous liver metastases: surgical and oncological outcomes with propensity-score analysis</title><source>SpringerNature Complete Journals</source><creator>Salvador-Rosés, H. ; López-Ben, S. ; Planellas, P. ; Canals, E. ; Casellas-Robert, M. ; Farrés, R. ; Ramos, E. ; Codina-Cazador, A. ; Figueras, J.</creator><creatorcontrib>Salvador-Rosés, H. ; López-Ben, S. ; Planellas, P. ; Canals, E. ; Casellas-Robert, M. ; Farrés, R. ; Ramos, E. ; Codina-Cazador, A. ; Figueras, J.</creatorcontrib><description>Background
The optimal sequence of surgery for rectal cancer (RC) with synchronous liver metastases (SLM) is controversial.
Objectives
The primary objective was to explore differences between the rectum first (RF) and the liver first strategy (LF) to achieve the complete resection (CR) of both tumors.
Methods
Patients diagnosed of RC with resectable or potentially resectable SLM were included. Data collected prospectively were analyzed with an intention-to-treat perspective, adjusting for between-sample differences (propensity score). The complete resection rate (CRR) was the main outcome variable.
Results
During a 5-year period, 23 patients underwent the LF strategy and 24 patients the RF strategy. Median overall survival (OS) was 32 months in the LF group and 41 months in the RF group (
p
= 0.499), and was 51 and 17 months, respectively, for patients achieving or not achieving CR of both tumors (
p
< 0.001). CRR’s were 65% in liver first group and 63% in rectum first group, (
p
= 0.846). No between-strategy differences in morbidity or duration of treatment were observed.
Conclusions
This study supports the notion that the achievement of CR of RC and SLM should be the goal of oncological treatment. Both RF and LF strategies are feasible and safe, but no between-strategy differences have been found in the CRR.</description><identifier>ISSN: 1699-048X</identifier><identifier>EISSN: 1699-3055</identifier><identifier>DOI: 10.1007/s12094-017-1712-4</identifier><identifier>PMID: 28707036</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Medicine ; Medicine & Public Health ; Oncology ; Research Article</subject><ispartof>Clinical & translational oncology, 2018-02, Vol.20 (2), p.221-229</ispartof><rights>Federación de Sociedades Españolas de Oncología (FESEO) 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-c426e15bf245aedfa4f1488602baf81ee8031b0696842e2912031792d456072a3</citedby><cites>FETCH-LOGICAL-c344t-c426e15bf245aedfa4f1488602baf81ee8031b0696842e2912031792d456072a3</cites><orcidid>0000-0002-6527-8674</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12094-017-1712-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12094-017-1712-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28707036$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salvador-Rosés, H.</creatorcontrib><creatorcontrib>López-Ben, S.</creatorcontrib><creatorcontrib>Planellas, P.</creatorcontrib><creatorcontrib>Canals, E.</creatorcontrib><creatorcontrib>Casellas-Robert, M.</creatorcontrib><creatorcontrib>Farrés, R.</creatorcontrib><creatorcontrib>Ramos, E.</creatorcontrib><creatorcontrib>Codina-Cazador, A.</creatorcontrib><creatorcontrib>Figueras, J.</creatorcontrib><title>Treatment strategies for rectal cancer with synchronous liver metastases: surgical and oncological outcomes with propensity-score analysis</title><title>Clinical & translational oncology</title><addtitle>Clin Transl Oncol</addtitle><addtitle>Clin Transl Oncol</addtitle><description>Background
The optimal sequence of surgery for rectal cancer (RC) with synchronous liver metastases (SLM) is controversial.
Objectives
The primary objective was to explore differences between the rectum first (RF) and the liver first strategy (LF) to achieve the complete resection (CR) of both tumors.
Methods
Patients diagnosed of RC with resectable or potentially resectable SLM were included. Data collected prospectively were analyzed with an intention-to-treat perspective, adjusting for between-sample differences (propensity score). The complete resection rate (CRR) was the main outcome variable.
Results
During a 5-year period, 23 patients underwent the LF strategy and 24 patients the RF strategy. Median overall survival (OS) was 32 months in the LF group and 41 months in the RF group (
p
= 0.499), and was 51 and 17 months, respectively, for patients achieving or not achieving CR of both tumors (
p
< 0.001). CRR’s were 65% in liver first group and 63% in rectum first group, (
p
= 0.846). No between-strategy differences in morbidity or duration of treatment were observed.
Conclusions
This study supports the notion that the achievement of CR of RC and SLM should be the goal of oncological treatment. Both RF and LF strategies are feasible and safe, but no between-strategy differences have been found in the CRR.</description><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Research Article</subject><issn>1699-048X</issn><issn>1699-3055</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kctqHDEQRUWIiZ1xPiCboGU2nVSp1S_vgvELDNnY4J3QaKrHbbqlsUodM7-Qr7acnmQZEEhVuvcg1RXiM8I3BGi-MyrodAHYFNigKvQ7cYJ11xUlVNX7wxl0-3AsPjI_Qe7WiB_EsWobaKCsT8Tvu0g2TeST5BRtou1ALPsQZSSX7Cid9Y6ifBnSo-S9d48x-DCzHIdfuT1RspwX8ZnkOW4Hly3Wb2TwLoxhqcOcXJgy9g9kF8OOPA9pX7ALkbLcjnse-FQc9XZk-nTYV-L-8uLu_Lq4_Xl1c_7jtnCl1qlwWtWE1bpXurK06a3uUbdtDWpt-xaJWihxDXVXt1qR6vKMSmw6tdFVDY2y5Up8Xbj5Jc8zcTLTwI7G0XrKPzPYKVCAZeasBC5SFwNzpN7s4jDZuDcI5i0Cs0RgcgTmLQKjs-fLAT-vJ9r8c_ydeRaoRcD5ym8pmqcwxzwE_g_1FYtrlJw</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Salvador-Rosés, H.</creator><creator>López-Ben, S.</creator><creator>Planellas, P.</creator><creator>Canals, E.</creator><creator>Casellas-Robert, M.</creator><creator>Farrés, R.</creator><creator>Ramos, E.</creator><creator>Codina-Cazador, A.</creator><creator>Figueras, J.</creator><general>Springer International Publishing</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6527-8674</orcidid></search><sort><creationdate>20180201</creationdate><title>Treatment strategies for rectal cancer with synchronous liver metastases: surgical and oncological outcomes with propensity-score analysis</title><author>Salvador-Rosés, H. ; López-Ben, S. ; Planellas, P. ; Canals, E. ; Casellas-Robert, M. ; Farrés, R. ; Ramos, E. ; Codina-Cazador, A. ; Figueras, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-c426e15bf245aedfa4f1488602baf81ee8031b0696842e2912031792d456072a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Research Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salvador-Rosés, H.</creatorcontrib><creatorcontrib>López-Ben, S.</creatorcontrib><creatorcontrib>Planellas, P.</creatorcontrib><creatorcontrib>Canals, E.</creatorcontrib><creatorcontrib>Casellas-Robert, M.</creatorcontrib><creatorcontrib>Farrés, R.</creatorcontrib><creatorcontrib>Ramos, E.</creatorcontrib><creatorcontrib>Codina-Cazador, A.</creatorcontrib><creatorcontrib>Figueras, J.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical & translational oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salvador-Rosés, H.</au><au>López-Ben, S.</au><au>Planellas, P.</au><au>Canals, E.</au><au>Casellas-Robert, M.</au><au>Farrés, R.</au><au>Ramos, E.</au><au>Codina-Cazador, A.</au><au>Figueras, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment strategies for rectal cancer with synchronous liver metastases: surgical and oncological outcomes with propensity-score analysis</atitle><jtitle>Clinical & translational oncology</jtitle><stitle>Clin Transl Oncol</stitle><addtitle>Clin Transl Oncol</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>20</volume><issue>2</issue><spage>221</spage><epage>229</epage><pages>221-229</pages><issn>1699-048X</issn><eissn>1699-3055</eissn><abstract>Background
The optimal sequence of surgery for rectal cancer (RC) with synchronous liver metastases (SLM) is controversial.
Objectives
The primary objective was to explore differences between the rectum first (RF) and the liver first strategy (LF) to achieve the complete resection (CR) of both tumors.
Methods
Patients diagnosed of RC with resectable or potentially resectable SLM were included. Data collected prospectively were analyzed with an intention-to-treat perspective, adjusting for between-sample differences (propensity score). The complete resection rate (CRR) was the main outcome variable.
Results
During a 5-year period, 23 patients underwent the LF strategy and 24 patients the RF strategy. Median overall survival (OS) was 32 months in the LF group and 41 months in the RF group (
p
= 0.499), and was 51 and 17 months, respectively, for patients achieving or not achieving CR of both tumors (
p
< 0.001). CRR’s were 65% in liver first group and 63% in rectum first group, (
p
= 0.846). No between-strategy differences in morbidity or duration of treatment were observed.
Conclusions
This study supports the notion that the achievement of CR of RC and SLM should be the goal of oncological treatment. Both RF and LF strategies are feasible and safe, but no between-strategy differences have been found in the CRR.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>28707036</pmid><doi>10.1007/s12094-017-1712-4</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6527-8674</orcidid></addata></record> |
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| source | SpringerNature Complete Journals |
| subjects | Medicine Medicine & Public Health Oncology Research Article |
| title | Treatment strategies for rectal cancer with synchronous liver metastases: surgical and oncological outcomes with propensity-score analysis |
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