Targeting VEGFR and FGFR in head and neck squamous cell carcinoma in vitro

Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease characterized by a tumor microenvironment (TME) that overexpresses vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR), which can lead to neovascularization, tumor growth and metasta...

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Veröffentlicht in:	Oncology reports 2017-09, Vol.38 (3), p.1877-1885
Hauptverfasser:	Brands, Roman C, Knierim, Luise M, De Donno, Francesco, Steinacker, Valentin, Hartmann, Stefan, Seher, Axel, Kübler, Alexander C, Müller-Richter, Urs D.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzimidazoles - pharmacology Cancer therapies Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - metabolism Care and treatment Cell growth Cell Line, Tumor Cell Proliferation - drug effects Development and progression fibroblast growth factor receptor Fibroblasts Gene expression Genetic aspects Genomes Growth factor receptors Head & neck cancer Head and neck cancer Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - metabolism head and neck squamous cell carcinoma Health aspects Humans Indoles - pharmacology Innovations Kinases Male Metastasis Molecular targeted therapy Patients Polymerase chain reaction Protein Kinase Inhibitors - pharmacology Pyrimidines - pharmacology Quinolones - pharmacology Receptor Protein-Tyrosine Kinases - metabolism Receptors, Vascular Endothelial Growth Factor - metabolism Signal Transduction - drug effects Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck Studies Sulfonamides - pharmacology Tumors Vascular endothelial growth factor vascular endothelial growth factor receptor
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