Melatonin protects against the pathological cardiac hypertrophy induced by transverse aortic constriction through activating PGC‐1β: In vivo and in vitro studies

Melatonin, a circadian molecule secreted by the pineal gland, confers a protective role against cardiac hypertrophy induced by hyperthyroidism, chronic hypoxia, and isoproterenol. However, its role against pressure overload‐induced cardiac hypertrophy and the underlying mechanisms remains elusive. I...

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Veröffentlicht in:	Journal of pineal research 2017-10, Vol.63 (3), p.n/a
Hauptverfasser:	Zhai, Mengen, Liu, Zhenhua, Zhang, Bin, Jing, Lin, Li, Buying, Li, Kaifeng, Chen, Xiuju, Zhang, Meng, Yu, Bo, Ren, Kai, Yang, Yang, Yi, Wei, Yang, Jian, Liu, Jincheng, Yi, Dinghua, Liang, Hongliang, Jin, Zhenxiao, Reiter, Russel J., Duan, Weixun, Yu, Shiqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Animals Antioxidants - pharmacology Antioxidants - therapeutic use cardiac hypertrophy Cardiomegaly - metabolism Cardiomegaly - pathology Cardiomegaly - prevention & control Disease Models, Animal Drug Evaluation, Preclinical Fibrosis Heart - drug effects Lung Diseases - prevention & control Male melatonin Melatonin - pharmacology Melatonin - therapeutic use Mice, Inbred C57BL Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - drug effects oxidative stress Oxidative Stress - drug effects Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism PGC‐1β Primary Cell Culture Transcriptional Activation - drug effects transverse aortic constriction
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