The sinomenine enteric-coated microspheres suppressed the TLR/NF-κB signaling in DSS-induced experimental colitis

Sinomenine is a pure alkaloid with immunosuppressive effects that is extracted from the Chinese medicinal plant Sinomenium acutum. We studied the therapeutic effects of sinomenine on inflammatory bowel disease. In this study, we randomly divided mice into the following ten groups: Control group; DSS...

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Veröffentlicht in:	International immunopharmacology 2017-09, Vol.50, p.251-262
Hauptverfasser:	Xiong, Huifang, Tian, Liang, Zhao, Zihan, Chen, Shuping, Zhao, Qiaoyun, Hong, Junbo, Xie, Yong, Zhou, Nanjin, Fu, Yingjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - therapeutic use Chitosan Colitis Colitis - chemically induced Colitis - drug therapy Colon - drug effects Colon - pathology Dextran Sulfate Disease Models, Animal Disease Progression Down-Regulation Drug Delivery Systems Female Inflammatory bowel disease Inflammatory Bowel Diseases - drug therapy Medicine, Chinese Traditional Mice Mice, Inbred BALB C Microspheres Morphinans - therapeutic use Myeloid Differentiation Factor 88 - metabolism NF-kappa B - metabolism Sinomenine Sinomenium - immunology Toll-Like Receptor 4 - metabolism Toll-like receptors
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