Deletion of Fstl1 (Follistatin-Like 1) From the Endocardial/Endothelial Lineage Causes Mitral Valve Disease

OBJECTIVE—Fstl1 (Follistatin-like 1) is a secreted protein that is expressed in the atrioventricular valves throughout embryonic development, postnatal maturation, and adulthood. In this study, we investigated the loss of Fstl1 in the endocardium/endothelium and their derived cells. APPROACH AND RES...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2017-09, Vol.37 (9), p.e116-e130
Hauptverfasser:	Prakash, Stuti, Borreguero, Luis J.J, Sylva, Marc, Flores Ruiz, Lorena, Rezai, Fereshte, Gunst, Quinn D, de la Pompa, José-Luis, Ruijter, Jan M, van den Hoff, Maurice J.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Morphogenetic Proteins - metabolism Cell Lineage Cell Proliferation Disease Models, Animal Disease Progression Endocardium - metabolism Endocardium - pathology Endothelial Cells - metabolism Endothelial Cells - pathology Epithelial-Mesenchymal Transition Follistatin-Related Proteins - deficiency Follistatin-Related Proteins - genetics Genetic Predisposition to Disease Heart Conduction System - metabolism Heart Conduction System - physiopathology Heart Failure - genetics Heart Failure - metabolism Heart Failure - pathology Heart Failure - physiopathology Integrases - genetics Mice, Knockout Mitral Valve - metabolism Mitral Valve - pathology Mitral Valve - physiopathology Mitral Valve Insufficiency - genetics Mitral Valve Insufficiency - metabolism Mitral Valve Insufficiency - pathology Mitral Valve Insufficiency - physiopathology Mitral Valve Prolapse - genetics Mitral Valve Prolapse - metabolism Mitral Valve Prolapse - pathology Mitral Valve Prolapse - physiopathology Phenotype Receptor, TIE-2 - genetics Signal Transduction Time Factors Transcription Factors - metabolism Transforming Growth Factor beta - metabolism Ventricular Dysfunction, Left - genetics Ventricular Dysfunction, Left - metabolism Ventricular Dysfunction, Left - pathology Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left Ventricular Remodeling
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