Clonal evolution in paired endometrial intraepithelial neoplasia/atypical hyperplasia and endometrioid adenocarcinoma

Endometrial intraepithelial neoplasia (EIN) and atypical endometrial hyperplasia (AH) are histomorphologically defined precursors to endometrioid adenocarcinoma, which are unified as EIN/AH by the World Health Organization. EIN/AH harbors a constellation of molecular alterations similar to those fou...

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Veröffentlicht in:	Human pathology 2017-09, Vol.67, p.69-77
Hauptverfasser:	Russo, Mariano, Broach, James, Sheldon, Kathryn, Houser, Kenneth R., Liu, Dajiang J., Kesterson, Joshua, Phaeton, Rebecca, Hossler, Carrie, Hempel, Nadine, Baker, Maria, Newell, Jordan M., Zaino, Richard, Warrick, Joshua I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Biopsy Cancer Carcinoma in Situ - enzymology Carcinoma in Situ - genetics Carcinoma in Situ - pathology Carcinoma in Situ - surgery Carcinoma, Endometrioid - enzymology Carcinoma, Endometrioid - genetics Carcinoma, Endometrioid - pathology Carcinoma, Endometrioid - surgery Cell Proliferation Clonal Evolution Deoxyribonucleic acid Disease Progression DNA DNA Copy Number Variations DNA Mismatch Repair DNA Repair Enzymes - analysis Endometrial cancer Endometrial hyperplasia Endometrial Hyperplasia - enzymology Endometrial Hyperplasia - genetics Endometrial Hyperplasia - pathology Endometrial Hyperplasia - surgery Endometrial intraepithelial neoplasia Endometrial Neoplasms - enzymology Endometrial Neoplasms - genetics Endometrial Neoplasms - pathology Endometrial Neoplasms - surgery Endometrioid adenocarcinoma Esophagus Female Gene Dosage Genes Genetic Predisposition to Disease Genomes Gynecology High-Throughput Nucleotide Sequencing Humans Hysterectomy Immunohistochemistry Microsatellite Instability Middle Aged Mutation Next generation sequencing Phenotype Proteins
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