Cell-Specific Pathways Supporting Persistent Fibrosis in Heart Failure

Only limited data exist describing the histologic and noncardiomyocyte function of human myocardium in end-stage heart failure (HF). The authors sought to determine changes in noncardiomyocyte cellular activity in patients with end-stage HF after left ventricular assist device (LVAD)-induced remodel...

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Veröffentlicht in:	Journal of the American College of Cardiology 2017-07, Vol.70 (3), p.344-354
Hauptverfasser:	Farris, Stephen D., Don, Creighton, Helterline, Deri, Costa, Christopher, Plummer, Tabitha, Steffes, Susanne, Mahr, Claudius, Mokadam, Nahush A., Stempien-Otero, April
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiology Catheterization Collagen Collagen - biosynthesis Density Echocardiography Extracellular matrix Female Fibroblasts Fibrosis Fibrosis - etiology Fibrosis - metabolism Fibrosis - pathology Follow-Up Studies Gene expression Heart Heart diseases Heart failure Heart Failure - complications Heart Failure - diagnosis Heart Failure - therapy Heart transplantation Heart-Assist Devices Histology Human subjects Humans Immunohistochemistry left ventricular assist device Leukocytes (mononuclear) Macrophages Male Mechanical unloading Middle Aged myocardial biology Myocardium Myocardium - metabolism Myocardium - pathology Polarization Polymerase chain reaction Prospective Studies remodeling Reverse transcription Studies translational studies Transplantation Transplants & implants Variance analysis Ventricle Ventricular Remodeling
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