Investigation of L-leucine in reducing the moisture-induced deterioration of spray-dried salbutamol sulfate power for inhalation

[Display omitted] The aim of this study was to investigate the ability of L-leucine (LL) in preventing moisture-induced deterioration in the in vitro aerosolization performance of spray-dried (SD) salbutamol sulfate (SS). Increasing mass fraction of LL (5–80%) were co-spray dried with SS, and the ph...

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Veröffentlicht in:	International journal of pharmaceutics 2017-09, Vol.530 (1-2), p.30-39
Hauptverfasser:	Li, Liang, Leung, Sharon Shui Yee, Gengenbach, Thomas, Yu, Jiaqi, Gao, Ge (Fiona), Tang, Patricia, Zhou, Qi (Tony), Chan, Hak-Kim
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Aerosols Albuterol - administration & dosage Chemistry, Pharmaceutical Dry powder inhalers L-leucine Leucine - chemistry Moisture protection Particle Size Powders Recrystallization Salbutamol sulfate Spray drying
Online-Zugang:	Volltext
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