Fatal Clostridium septicum multifocal myonecrosis in a previously healthy 25-year-old man: Role of NSAIDs?
We report a fatal septic shock due to a multifocal clostridial myonecrosis in a previously healthy young patient whose presentation and outcome may have been affected by Non-Steroidal Anti-Inflammatory Drug (NSAID) exposure. Death occurred 12 hours after his admission to the Emergency Department (ED...
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| Veröffentlicht in: | Médecine et maladies infectieuses 2017-10, Vol.47 (6), p.432-434 |
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| creator | Contou, D. Lecronier, M. Bitot, V. Hersant, B. Zakine, A. Hua, C. de Prost, N. |
| description | We report a fatal septic shock due to a multifocal clostridial myonecrosis in a previously healthy young patient whose presentation and outcome may have been affected by Non-Steroidal Anti-Inflammatory Drug (NSAID) exposure. Death occurred 12 hours after his admission to the Emergency Department (ED) despite prompt surgical debridement and appropriate antibiotics. A previously healthy 25-year-old male patient presented to the ED for a sudden pain of the right forearm and left buttock that had appeared simultaneously 24 hours earlier. Re also reported a 48-hour history of pharyngitis for which he had taken oral ibuprofen. There was no recent trauma but the patient used to practice intensive bodybuilding. Clostridial myonecrosis is a rare but life-threatening condition. In the absence of trauma, Clostridiurn septicum is the leading microorganism mostly observed in patients presenting with hematological malignancies or colon cancer. Prompt surgical debridement and timely antibiotic administration are needed. Clinical presentation and outcome may be altered by NSAID consumption. |
| doi_str_mv | 10.1016/j.medmal.2017.06.002 |
| format | Article |
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Death occurred 12 hours after his admission to the Emergency Department (ED) despite prompt surgical debridement and appropriate antibiotics. A previously healthy 25-year-old male patient presented to the ED for a sudden pain of the right forearm and left buttock that had appeared simultaneously 24 hours earlier. Re also reported a 48-hour history of pharyngitis for which he had taken oral ibuprofen. There was no recent trauma but the patient used to practice intensive bodybuilding. Clostridial myonecrosis is a rare but life-threatening condition. In the absence of trauma, Clostridiurn septicum is the leading microorganism mostly observed in patients presenting with hematological malignancies or colon cancer. Prompt surgical debridement and timely antibiotic administration are needed. Clinical presentation and outcome may be altered by NSAID consumption.</description><identifier>ISSN: 0399-077X</identifier><identifier>EISSN: 1769-6690</identifier><identifier>DOI: 10.1016/j.medmal.2017.06.002</identifier><identifier>PMID: 28705640</identifier><language>eng</language><publisher>France: Elsevier SAS</publisher><subject>Adult ; Anti-inflammatoires non stéroïdiens ; Anti-Inflammatory Agents, Non-Steroidal - adverse effects ; Antibiotics ; Bodybuilding ; Clostridium septicum ; Colon ; Colon cancer ; Drug overdose ; Emergency medical services ; Fatal Outcome ; Fatalities ; Forearm ; Gas Gangrene - chemically induced ; Gas Gangrene - complications ; Gas Gangrene - diagnosis ; Gas Gangrene - therapy ; Hematology ; Humans ; Ibuprofen ; Inflammation ; Male ; Muscle, Skeletal - pathology ; Myonecrosis ; Myonécrose ; Necrosis - chemically induced ; Necrosis - complications ; Non-steroidal anti-inflammatory drugs ; Nonsteroidal anti-inflammatory drugs ; Pain ; Pharyngitis ; Septic shock ; Surgery ; Trauma</subject><ispartof>Médecine et maladies infectieuses, 2017-10, Vol.47 (6), p.432-434</ispartof><rights>2017 Elsevier Masson SAS</rights><rights>Copyright Elsevier Science Ltd. 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Death occurred 12 hours after his admission to the Emergency Department (ED) despite prompt surgical debridement and appropriate antibiotics. A previously healthy 25-year-old male patient presented to the ED for a sudden pain of the right forearm and left buttock that had appeared simultaneously 24 hours earlier. Re also reported a 48-hour history of pharyngitis for which he had taken oral ibuprofen. There was no recent trauma but the patient used to practice intensive bodybuilding. Clostridial myonecrosis is a rare but life-threatening condition. In the absence of trauma, Clostridiurn septicum is the leading microorganism mostly observed in patients presenting with hematological malignancies or colon cancer. Prompt surgical debridement and timely antibiotic administration are needed. Clinical presentation and outcome may be altered by NSAID consumption.</description><subject>Adult</subject><subject>Anti-inflammatoires non stéroïdiens</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</subject><subject>Antibiotics</subject><subject>Bodybuilding</subject><subject>Clostridium septicum</subject><subject>Colon</subject><subject>Colon cancer</subject><subject>Drug overdose</subject><subject>Emergency medical services</subject><subject>Fatal Outcome</subject><subject>Fatalities</subject><subject>Forearm</subject><subject>Gas Gangrene - chemically induced</subject><subject>Gas Gangrene - complications</subject><subject>Gas Gangrene - diagnosis</subject><subject>Gas Gangrene - therapy</subject><subject>Hematology</subject><subject>Humans</subject><subject>Ibuprofen</subject><subject>Inflammation</subject><subject>Male</subject><subject>Muscle, Skeletal - pathology</subject><subject>Myonecrosis</subject><subject>Myonécrose</subject><subject>Necrosis - chemically induced</subject><subject>Necrosis - complications</subject><subject>Non-steroidal anti-inflammatory drugs</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Pain</subject><subject>Pharyngitis</subject><subject>Septic shock</subject><subject>Surgery</subject><subject>Trauma</subject><issn>0399-077X</issn><issn>1769-6690</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2L1TAUhoMoznX0H4gE3LhpTdI0aVwow3VmHBgU_AB3IU1OmZS0uSbtQP-9udzRhQuzSeA85-TwvAi9pKSmhIq3Yz2Bm0yoGaGyJqImhD1COyqFqoRQ5DHakUapikj58ww9y3ksQGHJU3TGOklawckOjVdmMQHvQ8xL8s6vE85wWLwtj2kNix-iLfVpizPYFLPP2M_Y4EOCex_XHDZ8ByYsdxtmbbWBSVUMDk9mfoe_xgA4Dvjzt4ubj_nDc_RkMCHDi4f7HP24uvy-_1Tdfrm-2V_cVrZhZKmY4HZQTrZs6DvV2r51wDmBTvZGUmoluEa1nDNLHBuA2r6xrJGko33PjBXNOXpzmntI8dcKedGTzxZCMDOUjTVVxYLiTaMK-vofdIxrmst2mtFyGOt4Wyh-oo4CcoJBH5KfTNo0JfqYhR71KQt9zEIToYvq0vbqYfjal_Lfpj_yC_D-BECxce8h6Ww9zBacT2AX7aL__w-_AUowm9w</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Contou, D.</creator><creator>Lecronier, M.</creator><creator>Bitot, V.</creator><creator>Hersant, B.</creator><creator>Zakine, A.</creator><creator>Hua, C.</creator><creator>de Prost, N.</creator><general>Elsevier SAS</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201710</creationdate><title>Fatal Clostridium septicum multifocal myonecrosis in a previously healthy 25-year-old man: Role of NSAIDs?</title><author>Contou, D. ; Lecronier, M. ; Bitot, V. ; Hersant, B. ; Zakine, A. ; Hua, C. ; de Prost, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-264cf9d752fb895cb5de440e87ba711c7ed395442c0d2fe1cb3c237081bb2ac63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Anti-inflammatoires non stéroïdiens</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</topic><topic>Antibiotics</topic><topic>Bodybuilding</topic><topic>Clostridium septicum</topic><topic>Colon</topic><topic>Colon cancer</topic><topic>Drug overdose</topic><topic>Emergency medical services</topic><topic>Fatal Outcome</topic><topic>Fatalities</topic><topic>Forearm</topic><topic>Gas Gangrene - chemically induced</topic><topic>Gas Gangrene - complications</topic><topic>Gas Gangrene - diagnosis</topic><topic>Gas Gangrene - therapy</topic><topic>Hematology</topic><topic>Humans</topic><topic>Ibuprofen</topic><topic>Inflammation</topic><topic>Male</topic><topic>Muscle, Skeletal - pathology</topic><topic>Myonecrosis</topic><topic>Myonécrose</topic><topic>Necrosis - chemically induced</topic><topic>Necrosis - complications</topic><topic>Non-steroidal anti-inflammatory drugs</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Pain</topic><topic>Pharyngitis</topic><topic>Septic shock</topic><topic>Surgery</topic><topic>Trauma</topic><toplevel>online_resources</toplevel><creatorcontrib>Contou, D.</creatorcontrib><creatorcontrib>Lecronier, M.</creatorcontrib><creatorcontrib>Bitot, V.</creatorcontrib><creatorcontrib>Hersant, B.</creatorcontrib><creatorcontrib>Zakine, A.</creatorcontrib><creatorcontrib>Hua, C.</creatorcontrib><creatorcontrib>de Prost, N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Médecine et maladies infectieuses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Contou, D.</au><au>Lecronier, M.</au><au>Bitot, V.</au><au>Hersant, B.</au><au>Zakine, A.</au><au>Hua, C.</au><au>de Prost, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fatal Clostridium septicum multifocal myonecrosis in a previously healthy 25-year-old man: Role of NSAIDs?</atitle><jtitle>Médecine et maladies infectieuses</jtitle><addtitle>Med Mal Infect</addtitle><date>2017-10</date><risdate>2017</risdate><volume>47</volume><issue>6</issue><spage>432</spage><epage>434</epage><pages>432-434</pages><issn>0399-077X</issn><eissn>1769-6690</eissn><abstract>We report a fatal septic shock due to a multifocal clostridial myonecrosis in a previously healthy young patient whose presentation and outcome may have been affected by Non-Steroidal Anti-Inflammatory Drug (NSAID) exposure. Death occurred 12 hours after his admission to the Emergency Department (ED) despite prompt surgical debridement and appropriate antibiotics. A previously healthy 25-year-old male patient presented to the ED for a sudden pain of the right forearm and left buttock that had appeared simultaneously 24 hours earlier. Re also reported a 48-hour history of pharyngitis for which he had taken oral ibuprofen. There was no recent trauma but the patient used to practice intensive bodybuilding. Clostridial myonecrosis is a rare but life-threatening condition. In the absence of trauma, Clostridiurn septicum is the leading microorganism mostly observed in patients presenting with hematological malignancies or colon cancer. Prompt surgical debridement and timely antibiotic administration are needed. Clinical presentation and outcome may be altered by NSAID consumption.</abstract><cop>France</cop><pub>Elsevier SAS</pub><pmid>28705640</pmid><doi>10.1016/j.medmal.2017.06.002</doi><tpages>3</tpages></addata></record> |
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| ispartof | Médecine et maladies infectieuses, 2017-10, Vol.47 (6), p.432-434 |
| issn | 0399-077X 1769-6690 |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adult Anti-inflammatoires non stéroïdiens Anti-Inflammatory Agents, Non-Steroidal - adverse effects Antibiotics Bodybuilding Clostridium septicum Colon Colon cancer Drug overdose Emergency medical services Fatal Outcome Fatalities Forearm Gas Gangrene - chemically induced Gas Gangrene - complications Gas Gangrene - diagnosis Gas Gangrene - therapy Hematology Humans Ibuprofen Inflammation Male Muscle, Skeletal - pathology Myonecrosis Myonécrose Necrosis - chemically induced Necrosis - complications Non-steroidal anti-inflammatory drugs Nonsteroidal anti-inflammatory drugs Pain Pharyngitis Septic shock Surgery Trauma |
| title | Fatal Clostridium septicum multifocal myonecrosis in a previously healthy 25-year-old man: Role of NSAIDs? |
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