A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors

Pyrrolidine‐based iminocyclitols are a promising class of glycosidase inhibitors. Reported herein is a convenient epimerization strategy that provides direct access to a range of stereoisomeric iminocyclitol inhibitors of O‐GlcNAcase (OGA), the enzyme responsible for catalyzing removal of O‐GlcNAc f...

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Veröffentlicht in:	Angewandte Chemie 2015-12, Vol.127 (51), p.15649-15653
Hauptverfasser:	Bergeron-Brlek, Milan, Goodwin-Tindall, Jake, Cekic, Nevena, Roth, Christian, Zandberg, Wesley F., Shan, Xiaoyang, Varghese, Vimal, Chan, Sherry, Davies, Gideon J., Vocadlo, David J., Britton, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Binding Brain Chemistry Enzyme Glycosidases Glykoside Heterocyclen Hydrolasen Inhibitoren Inhibitors Proteins Rodents Strategy
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