Microbiome and pediatric atopic dermatitis
Atopic dermatitis is a chronic inflammatory skin condition with drastic impacts on pediatric health. The pathogenesis of this common disease is not well understood, and the complex role of the skin microbiome in the pathogenesis and progression of atopic dermatitis is being elucidated. Skin commensa...
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| Veröffentlicht in: | Journal of dermatology 2015-12, Vol.42 (12), p.1137-1142 |
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| container_issue | 12 |
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| container_title | Journal of dermatology |
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| creator | Powers, Claire E. McShane, Diana B. Gilligan, Peter H. Burkhart, Craig N. Morrell, Dean S. |
| description | Atopic dermatitis is a chronic inflammatory skin condition with drastic impacts on pediatric health. The pathogenesis of this common disease is not well understood, and the complex role of the skin microbiome in the pathogenesis and progression of atopic dermatitis is being elucidated. Skin commensal organisms promote normal immune system functions and prevent the colonization of pathogens. Alterations in the skin microbiome may lead to increased Staphylococcus aureus colonization and atopic dermatitis progression. Despite the evidence for their important role, probiotics have not been deemed efficacious for the treatment of atopic dermatitis, although studies suggest that probiotics may be effective at preventing the development of atopic dermatitis when given to young infants. This review will cover the most recent published work on the microbiome and pediatric atopic dermatitis. |
| doi_str_mv | 10.1111/1346-8138.13072 |
| format | Article |
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The pathogenesis of this common disease is not well understood, and the complex role of the skin microbiome in the pathogenesis and progression of atopic dermatitis is being elucidated. Skin commensal organisms promote normal immune system functions and prevent the colonization of pathogens. Alterations in the skin microbiome may lead to increased Staphylococcus aureus colonization and atopic dermatitis progression. Despite the evidence for their important role, probiotics have not been deemed efficacious for the treatment of atopic dermatitis, although studies suggest that probiotics may be effective at preventing the development of atopic dermatitis when given to young infants. 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The pathogenesis of this common disease is not well understood, and the complex role of the skin microbiome in the pathogenesis and progression of atopic dermatitis is being elucidated. Skin commensal organisms promote normal immune system functions and prevent the colonization of pathogens. Alterations in the skin microbiome may lead to increased Staphylococcus aureus colonization and atopic dermatitis progression. Despite the evidence for their important role, probiotics have not been deemed efficacious for the treatment of atopic dermatitis, although studies suggest that probiotics may be effective at preventing the development of atopic dermatitis when given to young infants. This review will cover the most recent published work on the microbiome and pediatric atopic dermatitis.</description><subject>antimicrobial cationic peptides</subject><subject>atopic dermatitis</subject><subject>Child</subject><subject>Dermatitis</subject><subject>Dermatitis, Atopic - etiology</subject><subject>Dermatitis, Atopic - microbiology</subject><subject>Dermatitis, Atopic - therapy</subject><subject>Eczema</subject><subject>Humans</subject><subject>Microbiota</subject><subject>Pathogenesis</subject><subject>Probiotics</subject><subject>Probiotics - therapeutic use</subject><subject>Quality of life</subject><subject>Skin - microbiology</subject><subject>Staphylococcal Skin Infections - complications</subject><subject>Staphylococcal Skin Infections - microbiology</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - isolation & purification</subject><subject>Staphylococcus aureus - pathogenicity</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEURoMoWqtrd1JwI8K0Se7kMUup2vou4mMZkmkGop1OTWbQ_ntTR7tw491cuJzvg3sQOiC4T-IMCKQ8kQRknwAWdAN11pdN1MEgWUJTLHbQbgivGNOMEbyNdigHKRnhHXRy63JfGVeVtqfn097CTp2uvct7uq4WcU2tL3Xtahf20FahZ8Hu_-wuero4fxyOk5v70eXw9CbJeQo0KTRQYiRIkzJdWGILygwGQwkXIrUYMCMZYbjIsDFaEgMEOCMpEznoVFDoouO2d-Gr98aGWpUu5HY203NbNUHFdJZxKbj4HxUcS8YhhYge_UFfq8bP4yORYoJRKviKGrRUlBKCt4VaeFdqv1QEq5VxtfKrVn7Vt_GYOPzpbUxpp2v-V3EEWAt8uJld_tenrs7Of4uTNudCbT_XOe3fVPxcMPVyN1LXz_hiPHmYqDF8AXVjlZk</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Powers, Claire E.</creator><creator>McShane, Diana B.</creator><creator>Gilligan, Peter H.</creator><creator>Burkhart, Craig N.</creator><creator>Morrell, Dean S.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201512</creationdate><title>Microbiome and pediatric atopic dermatitis</title><author>Powers, Claire E. ; McShane, Diana B. ; Gilligan, Peter H. ; Burkhart, Craig N. ; Morrell, Dean S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6432-fa321b838b45afe1ef25b03b216774e030519150f90bba81b313651457c3a4723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>antimicrobial cationic peptides</topic><topic>atopic dermatitis</topic><topic>Child</topic><topic>Dermatitis</topic><topic>Dermatitis, Atopic - etiology</topic><topic>Dermatitis, Atopic - microbiology</topic><topic>Dermatitis, Atopic - therapy</topic><topic>Eczema</topic><topic>Humans</topic><topic>Microbiota</topic><topic>Pathogenesis</topic><topic>Probiotics</topic><topic>Probiotics - therapeutic use</topic><topic>Quality of life</topic><topic>Skin - microbiology</topic><topic>Staphylococcal Skin Infections - complications</topic><topic>Staphylococcal Skin Infections - microbiology</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - isolation & purification</topic><topic>Staphylococcus aureus - pathogenicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Powers, Claire E.</creatorcontrib><creatorcontrib>McShane, Diana B.</creatorcontrib><creatorcontrib>Gilligan, Peter H.</creatorcontrib><creatorcontrib>Burkhart, Craig N.</creatorcontrib><creatorcontrib>Morrell, Dean S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Powers, Claire E.</au><au>McShane, Diana B.</au><au>Gilligan, Peter H.</au><au>Burkhart, Craig N.</au><au>Morrell, Dean S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microbiome and pediatric atopic dermatitis</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2015-12</date><risdate>2015</risdate><volume>42</volume><issue>12</issue><spage>1137</spage><epage>1142</epage><pages>1137-1142</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>Atopic dermatitis is a chronic inflammatory skin condition with drastic impacts on pediatric health. 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| subjects | antimicrobial cationic peptides atopic dermatitis Child Dermatitis Dermatitis, Atopic - etiology Dermatitis, Atopic - microbiology Dermatitis, Atopic - therapy Eczema Humans Microbiota Pathogenesis Probiotics Probiotics - therapeutic use Quality of life Skin - microbiology Staphylococcal Skin Infections - complications Staphylococcal Skin Infections - microbiology Staphylococcus aureus Staphylococcus aureus - isolation & purification Staphylococcus aureus - pathogenicity |
| title | Microbiome and pediatric atopic dermatitis |
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