Design and Synthesis of α, β-Epoxyketones as New Anticancer Agents

As epoxy functional group has high anticancer activity, α, β-epoxyketones were designed and synthesized as new anticancer agents, and their structures were confirmed by UV, 1H NMR, IR, MS technigeces and elemental analysis. Their in vitro anticancer activities were evaluated by MTF method and the re...

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Veröffentlicht in:	Chinese journal of chemistry 2011-04, Vol.29 (4), p.757-764
1. Verfasser:	马正月 张兴华 王士奎 何洋 杨更亮 李蓓蕾 杨俊杰 鲁悦娟 孙杰威
Format:	Artikel
Sprache:	eng
Schlagworte:	anticancer activity Darzens condensation reaction Hela HepG2细胞 IC50 thiochromanones α,β‐epoxyketones β-epoxyketones 元素分析 抗癌活性 抗癌药物
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