The apparently very variable potency of the anti-depressant fluoxetine
•Different aquatic species appear to have very different sensitivities to fluoxetine.•Some species of invertebrate appear to be extremely sensitive to fluoxetine.•Many published studies have major limitations.•It is currently unclear whether or not fluoxetine presents an environmental risk. The anti...
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| Veröffentlicht in: | Aquatic toxicology 2014-06, Vol.151, p.57-60 |
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| container_title | Aquatic toxicology |
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| creator | Sumpter, J.P. Donnachie, R.L. Johnson, A.C. |
| description | •Different aquatic species appear to have very different sensitivities to fluoxetine.•Some species of invertebrate appear to be extremely sensitive to fluoxetine.•Many published studies have major limitations.•It is currently unclear whether or not fluoxetine presents an environmental risk.
The anti-depressant fluoxetine is widely present in the aquatic environment. Typical river concentrations are in the low ng/L range. Many ecotoxicity studies have assessed the effects of this pharmaceutical on a range of aquatic species. Some studies report that ng, or even pg, per litre concentrations cause effects, whereas other studies report that effects only occur when the water concentration is in the μg/L range. It seems unlikely that all reported effects will be repeatable. Many of the studies have considerable limitations. Currently it is impossible to ascertain what environmental concentrations of fluoxetine pose a risk to aquatic organisms. The key question can be answered only by high quality, reproducible research. |
| doi_str_mv | 10.1016/j.aquatox.2013.12.010 |
| format | Article |
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The anti-depressant fluoxetine is widely present in the aquatic environment. Typical river concentrations are in the low ng/L range. Many ecotoxicity studies have assessed the effects of this pharmaceutical on a range of aquatic species. Some studies report that ng, or even pg, per litre concentrations cause effects, whereas other studies report that effects only occur when the water concentration is in the μg/L range. It seems unlikely that all reported effects will be repeatable. Many of the studies have considerable limitations. Currently it is impossible to ascertain what environmental concentrations of fluoxetine pose a risk to aquatic organisms. The key question can be answered only by high quality, reproducible research.</description><identifier>ISSN: 0166-445X</identifier><identifier>EISSN: 1879-1514</identifier><identifier>DOI: 10.1016/j.aquatox.2013.12.010</identifier><identifier>PMID: 24411166</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Fish ; Fishes ; Fluoxetine ; Fluoxetine - toxicity ; Freshwater ; Invertebrates ; Invertebrates - drug effects ; Research - standards ; Species Specificity ; Toxicology - standards ; Variable potency ; Water Pollutants, Chemical - toxicity</subject><ispartof>Aquatic toxicology, 2014-06, Vol.151, p.57-60</ispartof><rights>2014 The Authors</rights><rights>Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-652d69c16f39beb50c142e78b5c85dce003c9a780df370c8b9cfa00725685d6b3</citedby><cites>FETCH-LOGICAL-c478t-652d69c16f39beb50c142e78b5c85dce003c9a780df370c8b9cfa00725685d6b3</cites><orcidid>0000-0002-1290-6980</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.aquatox.2013.12.010$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24411166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sumpter, J.P.</creatorcontrib><creatorcontrib>Donnachie, R.L.</creatorcontrib><creatorcontrib>Johnson, A.C.</creatorcontrib><title>The apparently very variable potency of the anti-depressant fluoxetine</title><title>Aquatic toxicology</title><addtitle>Aquat Toxicol</addtitle><description>•Different aquatic species appear to have very different sensitivities to fluoxetine.•Some species of invertebrate appear to be extremely sensitive to fluoxetine.•Many published studies have major limitations.•It is currently unclear whether or not fluoxetine presents an environmental risk.
The anti-depressant fluoxetine is widely present in the aquatic environment. Typical river concentrations are in the low ng/L range. Many ecotoxicity studies have assessed the effects of this pharmaceutical on a range of aquatic species. Some studies report that ng, or even pg, per litre concentrations cause effects, whereas other studies report that effects only occur when the water concentration is in the μg/L range. It seems unlikely that all reported effects will be repeatable. Many of the studies have considerable limitations. Currently it is impossible to ascertain what environmental concentrations of fluoxetine pose a risk to aquatic organisms. The key question can be answered only by high quality, reproducible research.</description><subject>Animals</subject><subject>Fish</subject><subject>Fishes</subject><subject>Fluoxetine</subject><subject>Fluoxetine - toxicity</subject><subject>Freshwater</subject><subject>Invertebrates</subject><subject>Invertebrates - drug effects</subject><subject>Research - standards</subject><subject>Species Specificity</subject><subject>Toxicology - standards</subject><subject>Variable potency</subject><subject>Water Pollutants, Chemical - toxicity</subject><issn>0166-445X</issn><issn>1879-1514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAQgIMouj5-gtKjl9ZMmqTNSUR8geBFwVtI0ylm6bY1ScX992bZ1atzmBmYb2bgI-QcaAEU5NWyMJ-zieN3wSiUBbCCAt0jC6grlYMAvk8WiZM55-L9iByHsKQpGFeH5IhxDpCGC3L_-oGZmSbjcYj9OvtCn5LxzjQ9ZtMYcbDrbOyyuOGG6PIWJ48hpD7r-nn8xugGPCUHnekDnu3qCXm7v3u9fcyfXx6ebm-ec8urOuZSsFYqC7IrVYONoBY4w6puhK1Fa5HS0ipT1bTtyoraulG2M5RWTMg0l015Qi63dyc_fs4Yol65YLHvzYDjHDQoUEqIktb_o5JVikslZULFFrV-DMFjpyfvVsavNVC9sa2Xemdbb2xrYDrZTnsXuxdzs8L2b-tXbwKutwAmJ18OvQ7WJaPYOo826nZ0_7z4AcOpk2s</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Sumpter, J.P.</creator><creator>Donnachie, R.L.</creator><creator>Johnson, A.C.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7ST</scope><scope>7TV</scope><scope>7U1</scope><scope>7U2</scope><scope>7U7</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>SOI</scope><orcidid>https://orcid.org/0000-0002-1290-6980</orcidid></search><sort><creationdate>20140601</creationdate><title>The apparently very variable potency of the anti-depressant fluoxetine</title><author>Sumpter, J.P. ; 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| fulltext | fulltext |
| identifier | ISSN: 0166-445X |
| ispartof | Aquatic toxicology, 2014-06, Vol.151, p.57-60 |
| issn | 0166-445X 1879-1514 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Fish Fishes Fluoxetine Fluoxetine - toxicity Freshwater Invertebrates Invertebrates - drug effects Research - standards Species Specificity Toxicology - standards Variable potency Water Pollutants, Chemical - toxicity |
| title | The apparently very variable potency of the anti-depressant fluoxetine |
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