CD73‐derived adenosine and tenascin‐C control cytokine production by epicardium‐derived cells formed after myocardial infarction

ABSTRACT Epicardium‐derived cells (EPDCs) play a fundamental role in embryonic cardiac development and are reactivated in the adult heart in response to myocardial infarction (MI). In this study, EPDCs from post‐MI rat hearts highly expressed the ectoenzyme CD73 and secreted the profibrotic matricel...

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Veröffentlicht in:	The FASEB journal 2017-07, Vol.31 (7), p.3040-3053
Hauptverfasser:	Hesse, Julia, Leberling, Stella, Boden, Elisabeth, Friebe, Daniela, Schmidt, Timo, Ding, Zhaoping, Dieterich, Peter, Deussen, Andreas, Roderigo, Claudia, Rose, Christine R., Floss, Doreen M., Scheller, Jürgen, Schrader, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	5'-Nucleotidase - metabolism A2B receptor Adenosine Adenosine - metabolism Adenosine triphosphate Animals ATP Brefeldin A CD73 antigen Control theory Cytokines Cytokines - metabolism Embryogenesis Epicardium Feedback loops Gene Expression Regulation - physiology Heart Heart attacks Heart diseases IL‐6 inflammasome Inflammasomes Inflammation Interleukin 11 Interleukin 6 Intracellular signalling Male mesenchymal cells Myocardial infarction Myocardial Infarction - metabolism Myocardial Infarction - pathology NAD Nucleotides P2X7 receptor Pericardium - cytology Rats Rats, Wistar Receptors, Purinergic P2X - genetics Receptors, Purinergic P2X - metabolism Receptors, Purinergic P2Y - genetics Receptors, Purinergic P2Y - metabolism Rodents Tenascin Tenascin - metabolism Tenascin C TLR4 protein Toll-like receptors Vascular endothelial growth factor
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