First trimester exposure to corticosteroids and oral clefts
BACKGROUND The possible association between oral cleft in the newborn and maternal exposure to corticoids during pregnancy is still controversial. The aim of this study was to test this association by a case‐control analysis using the large multicentric MADRE database. METHODS The MADRE database is...
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| Veröffentlicht in: | Birth defects research. A Clinical and molecular teratology 2003-12, Vol.67 (12), p.968-970 |
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| container_title | Birth defects research. A Clinical and molecular teratology |
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| creator | Pradat, Pierre Robert-Gnansia, Elisabeth Di Tanna, Gian Luca Rosano, Aldo Lisi, Alessandra Mastroiacovo, Pierpaolo |
| description | BACKGROUND
The possible association between oral cleft in the newborn and maternal exposure to corticoids during pregnancy is still controversial. The aim of this study was to test this association by a case‐control analysis using the large multicentric MADRE database.
METHODS
The MADRE database is a collection of information on malformed infants with a history of maternal first‐trimester drug exposure. Nine malformation registries participate in the data collection. Cases were defined as infants presenting with a cleft palate or cleft lip, and exposure was defined by the use of corticosteroids during the first trimester of pregnancy.
RESULTS
After 12 years of data collection, the database includes data on 11,150 malformed infants. A slight association is observed between exposure to corticoids for systemic use and the occurrence of cleft lip with or without cleft palate (OR, 2.59; 95% CI, 1.18–5.67).
CONCLUSIONS
If the observed association is real, an interpretation is suggested, based on a likely interaction between corticosteroids and environmental dioxins. It is indeed possible that human fetuses may become sensitive to the teratogenic effect of corticosteroids when they are exposed in utero to environmental pesticides as well. Birth Defects Research (Part A), 2003. © 2003 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/bdra.10134 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_19198167</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19198167</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5154-59da91efcf0c9621300c58a1230038bda5dc6b5f013d1c0cbf66e24bbc4cc3323</originalsourceid><addsrcrecordid>eNp9kEtPAjEUhRujEUQ3_gAzG12YjPYxnUdcIQpqUBODYdl07nSS6kCxnYnw7y0Ows7VPbn57uMchE4JviIY0-u8sNIrwqI91CU8oiFOYry_1Zx20JFzH55lSZIcog6JkohnhHfRzVBbVwe11TPlamUDtVwY11gV1CYAY2sNZt03unCBnBeBsbIKoFJl7Y7RQSkrp042tYfeh_eTwUM4fh09DvrjELj_IORZITOiSigxZDElDGPgqSTUC5bmheQFxDkvvYGCAIa8jGNFozyHCIAxynroot27sOar8W-KmXagqkrOlWmcIBnJUhInHrxsQbDGOatKsfC-pF0JgsU6KrGOSvxG5eGzzdYmn6lih26y8cD5BpAOZFVaOQftdhxnaZyyzHOk5b51pVb_nBS3d2_9v-NhO6N9uMvtjLSfwvtIuJi-jEQ0eabTJ8YEYz_T4I97</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19198167</pqid></control><display><type>article</type><title>First trimester exposure to corticosteroids and oral clefts</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Pradat, Pierre ; Robert-Gnansia, Elisabeth ; Di Tanna, Gian Luca ; Rosano, Aldo ; Lisi, Alessandra ; Mastroiacovo, Pierpaolo</creator><creatorcontrib>Pradat, Pierre ; Robert-Gnansia, Elisabeth ; Di Tanna, Gian Luca ; Rosano, Aldo ; Lisi, Alessandra ; Mastroiacovo, Pierpaolo ; Contributors to the MADRE database ; all contributors to the MADRE database</creatorcontrib><description>BACKGROUND
The possible association between oral cleft in the newborn and maternal exposure to corticoids during pregnancy is still controversial. The aim of this study was to test this association by a case‐control analysis using the large multicentric MADRE database.
METHODS
The MADRE database is a collection of information on malformed infants with a history of maternal first‐trimester drug exposure. Nine malformation registries participate in the data collection. Cases were defined as infants presenting with a cleft palate or cleft lip, and exposure was defined by the use of corticosteroids during the first trimester of pregnancy.
RESULTS
After 12 years of data collection, the database includes data on 11,150 malformed infants. A slight association is observed between exposure to corticoids for systemic use and the occurrence of cleft lip with or without cleft palate (OR, 2.59; 95% CI, 1.18–5.67).
CONCLUSIONS
If the observed association is real, an interpretation is suggested, based on a likely interaction between corticosteroids and environmental dioxins. It is indeed possible that human fetuses may become sensitive to the teratogenic effect of corticosteroids when they are exposed in utero to environmental pesticides as well. Birth Defects Research (Part A), 2003. © 2003 Wiley‐Liss, Inc.</description><identifier>ISSN: 1542-0752</identifier><identifier>EISSN: 1542-0760</identifier><identifier>DOI: 10.1002/bdra.10134</identifier><identifier>PMID: 14745915</identifier><identifier>CODEN: BDRPBT</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Abnormalities, Drug-Induced - epidemiology ; Abnormalities, Drug-Induced - etiology ; Adult ; Biological and medical sciences ; Cleft Lip - epidemiology ; Cleft Lip - etiology ; Cleft Palate - epidemiology ; Cleft Palate - etiology ; Embryology: invertebrates and vertebrates. Teratology ; Female ; Fundamental and applied biological sciences. Psychology ; Global Health ; Glucocorticoids - adverse effects ; Humans ; Infant, Newborn ; Maternal Exposure - adverse effects ; Pregnancy ; Pregnancy Trimester, First ; Registries ; Teratology. Teratogens ; World Health Organization</subject><ispartof>Birth defects research. A Clinical and molecular teratology, 2003-12, Vol.67 (12), p.968-970</ispartof><rights>Copyright © 2003 Wiley‐Liss, Inc.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2003 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5154-59da91efcf0c9621300c58a1230038bda5dc6b5f013d1c0cbf66e24bbc4cc3323</citedby><cites>FETCH-LOGICAL-c5154-59da91efcf0c9621300c58a1230038bda5dc6b5f013d1c0cbf66e24bbc4cc3323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbdra.10134$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbdra.10134$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15386839$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14745915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pradat, Pierre</creatorcontrib><creatorcontrib>Robert-Gnansia, Elisabeth</creatorcontrib><creatorcontrib>Di Tanna, Gian Luca</creatorcontrib><creatorcontrib>Rosano, Aldo</creatorcontrib><creatorcontrib>Lisi, Alessandra</creatorcontrib><creatorcontrib>Mastroiacovo, Pierpaolo</creatorcontrib><creatorcontrib>Contributors to the MADRE database</creatorcontrib><creatorcontrib>all contributors to the MADRE database</creatorcontrib><title>First trimester exposure to corticosteroids and oral clefts</title><title>Birth defects research. A Clinical and molecular teratology</title><addtitle>Birth Defects Research Part A: Clinical and Molecular Teratology</addtitle><description>BACKGROUND
The possible association between oral cleft in the newborn and maternal exposure to corticoids during pregnancy is still controversial. The aim of this study was to test this association by a case‐control analysis using the large multicentric MADRE database.
METHODS
The MADRE database is a collection of information on malformed infants with a history of maternal first‐trimester drug exposure. Nine malformation registries participate in the data collection. Cases were defined as infants presenting with a cleft palate or cleft lip, and exposure was defined by the use of corticosteroids during the first trimester of pregnancy.
RESULTS
After 12 years of data collection, the database includes data on 11,150 malformed infants. A slight association is observed between exposure to corticoids for systemic use and the occurrence of cleft lip with or without cleft palate (OR, 2.59; 95% CI, 1.18–5.67).
CONCLUSIONS
If the observed association is real, an interpretation is suggested, based on a likely interaction between corticosteroids and environmental dioxins. It is indeed possible that human fetuses may become sensitive to the teratogenic effect of corticosteroids when they are exposed in utero to environmental pesticides as well. Birth Defects Research (Part A), 2003. © 2003 Wiley‐Liss, Inc.</description><subject>Abnormalities, Drug-Induced - epidemiology</subject><subject>Abnormalities, Drug-Induced - etiology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cleft Lip - epidemiology</subject><subject>Cleft Lip - etiology</subject><subject>Cleft Palate - epidemiology</subject><subject>Cleft Palate - etiology</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Global Health</subject><subject>Glucocorticoids - adverse effects</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Maternal Exposure - adverse effects</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Registries</subject><subject>Teratology. Teratogens</subject><subject>World Health Organization</subject><issn>1542-0752</issn><issn>1542-0760</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPAjEUhRujEUQ3_gAzG12YjPYxnUdcIQpqUBODYdl07nSS6kCxnYnw7y0Ows7VPbn57uMchE4JviIY0-u8sNIrwqI91CU8oiFOYry_1Zx20JFzH55lSZIcog6JkohnhHfRzVBbVwe11TPlamUDtVwY11gV1CYAY2sNZt03unCBnBeBsbIKoFJl7Y7RQSkrp042tYfeh_eTwUM4fh09DvrjELj_IORZITOiSigxZDElDGPgqSTUC5bmheQFxDkvvYGCAIa8jGNFozyHCIAxynroot27sOar8W-KmXagqkrOlWmcIBnJUhInHrxsQbDGOatKsfC-pF0JgsU6KrGOSvxG5eGzzdYmn6lih26y8cD5BpAOZFVaOQftdhxnaZyyzHOk5b51pVb_nBS3d2_9v-NhO6N9uMvtjLSfwvtIuJi-jEQ0eabTJ8YEYz_T4I97</recordid><startdate>200312</startdate><enddate>200312</enddate><creator>Pradat, Pierre</creator><creator>Robert-Gnansia, Elisabeth</creator><creator>Di Tanna, Gian Luca</creator><creator>Rosano, Aldo</creator><creator>Lisi, Alessandra</creator><creator>Mastroiacovo, Pierpaolo</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>200312</creationdate><title>First trimester exposure to corticosteroids and oral clefts</title><author>Pradat, Pierre ; Robert-Gnansia, Elisabeth ; Di Tanna, Gian Luca ; Rosano, Aldo ; Lisi, Alessandra ; Mastroiacovo, Pierpaolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5154-59da91efcf0c9621300c58a1230038bda5dc6b5f013d1c0cbf66e24bbc4cc3323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Abnormalities, Drug-Induced - epidemiology</topic><topic>Abnormalities, Drug-Induced - etiology</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cleft Lip - epidemiology</topic><topic>Cleft Lip - etiology</topic><topic>Cleft Palate - epidemiology</topic><topic>Cleft Palate - etiology</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Global Health</topic><topic>Glucocorticoids - adverse effects</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Maternal Exposure - adverse effects</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Registries</topic><topic>Teratology. Teratogens</topic><topic>World Health Organization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pradat, Pierre</creatorcontrib><creatorcontrib>Robert-Gnansia, Elisabeth</creatorcontrib><creatorcontrib>Di Tanna, Gian Luca</creatorcontrib><creatorcontrib>Rosano, Aldo</creatorcontrib><creatorcontrib>Lisi, Alessandra</creatorcontrib><creatorcontrib>Mastroiacovo, Pierpaolo</creatorcontrib><creatorcontrib>Contributors to the MADRE database</creatorcontrib><creatorcontrib>all contributors to the MADRE database</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Birth defects research. A Clinical and molecular teratology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pradat, Pierre</au><au>Robert-Gnansia, Elisabeth</au><au>Di Tanna, Gian Luca</au><au>Rosano, Aldo</au><au>Lisi, Alessandra</au><au>Mastroiacovo, Pierpaolo</au><aucorp>Contributors to the MADRE database</aucorp><aucorp>all contributors to the MADRE database</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First trimester exposure to corticosteroids and oral clefts</atitle><jtitle>Birth defects research. A Clinical and molecular teratology</jtitle><addtitle>Birth Defects Research Part A: Clinical and Molecular Teratology</addtitle><date>2003-12</date><risdate>2003</risdate><volume>67</volume><issue>12</issue><spage>968</spage><epage>970</epage><pages>968-970</pages><issn>1542-0752</issn><eissn>1542-0760</eissn><coden>BDRPBT</coden><abstract>BACKGROUND
The possible association between oral cleft in the newborn and maternal exposure to corticoids during pregnancy is still controversial. The aim of this study was to test this association by a case‐control analysis using the large multicentric MADRE database.
METHODS
The MADRE database is a collection of information on malformed infants with a history of maternal first‐trimester drug exposure. Nine malformation registries participate in the data collection. Cases were defined as infants presenting with a cleft palate or cleft lip, and exposure was defined by the use of corticosteroids during the first trimester of pregnancy.
RESULTS
After 12 years of data collection, the database includes data on 11,150 malformed infants. A slight association is observed between exposure to corticoids for systemic use and the occurrence of cleft lip with or without cleft palate (OR, 2.59; 95% CI, 1.18–5.67).
CONCLUSIONS
If the observed association is real, an interpretation is suggested, based on a likely interaction between corticosteroids and environmental dioxins. It is indeed possible that human fetuses may become sensitive to the teratogenic effect of corticosteroids when they are exposed in utero to environmental pesticides as well. Birth Defects Research (Part A), 2003. © 2003 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>14745915</pmid><doi>10.1002/bdra.10134</doi><tpages>3</tpages></addata></record> |
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| ispartof | Birth defects research. A Clinical and molecular teratology, 2003-12, Vol.67 (12), p.968-970 |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Abnormalities, Drug-Induced - epidemiology Abnormalities, Drug-Induced - etiology Adult Biological and medical sciences Cleft Lip - epidemiology Cleft Lip - etiology Cleft Palate - epidemiology Cleft Palate - etiology Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Global Health Glucocorticoids - adverse effects Humans Infant, Newborn Maternal Exposure - adverse effects Pregnancy Pregnancy Trimester, First Registries Teratology. Teratogens World Health Organization |
| title | First trimester exposure to corticosteroids and oral clefts |
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