Prediction of Clinically Relevant Herb-Drug Clearance Interactions Using Sandwich-Cultured Human Hepatocytes: Schisandra spp. Case Study

The Schisandraceae family is reported to have a range of pharmacological activities, including anti-inflammatory effects. As with all herbal preparations, extracts of Schisandra species are mixtures composed of >50 lignans, especially schizandrins, deoxyschizandrins, and gomisins. In China, Schis...

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Veröffentlicht in:	Drug metabolism and disposition 2017-09, Vol.45 (9), p.1019-1026
Hauptverfasser:	Jackson, Jonathan P., Freeman, Kimberly M., Friley, Weslyn W., Herman, Ashley G., Black, Christopher B., Brouwer, Kenneth R., Roe, Amy L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Assessments Case studies Cells, Cultured Diet Dietary supplements Drug metabolism Hepatocytes Hepatocytes - cytology Hepatocytes - metabolism Herb-Drug Interactions Herbs Humans Inflammation Lignans Lignans - pharmacokinetics Lignans - pharmacology Liver Metabolism Midazolam Midazolam - pharmacokinetics Midazolam - pharmacology mRNA Pharmacology Plant Extracts - pharmacokinetics Plant Extracts - pharmacology Predictions Schisandra Schisandra - chemistry Transport
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