Postsorafenib systemic treatments for hepatocellular carcinoma: questions and opportunities after the regorafenib trial

The search for systemic therapies for hepatocellular carcinoma has been characterized by difficulties and failures. Despite recent progresses, many issues are still to be settled. In particular, the development of drugs inhibiting different neoplastic pathways remains a priority for patients intoler...

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Veröffentlicht in:	Future oncology (London, England) England), 2017-09, Vol.13 (21), p.1893-1905
Hauptverfasser:	Tovoli, Francesco, Lorenzo, Stefania De, Barbera, Maria Aurelia, Garajova, Ingrid, Frega, Giorgio, Palloni, Andrea, Pantaleo, Maria Abbondanza, Biasco, Guido, Brandi, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use cabozantinib Cancer therapies Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - therapy Clinical trials Clinical Trials as Topic Combined Modality Therapy Drug dosages hepatocellular carcinoma Humans Immunotherapy Inhibitor drugs Life expectancy Liver cancer Liver Neoplasms - mortality Liver Neoplasms - pathology Liver Neoplasms - therapy Medical prognosis Melanoma Molecular Targeted Therapy Monoclonal antibodies Niacinamide - analogs & derivatives Niacinamide - therapeutic use nivolumab Phenylurea Compounds - administration & dosage Phenylurea Compounds - adverse effects Phenylurea Compounds - therapeutic use Pyridines - administration & dosage Pyridines - adverse effects Pyridines - therapeutic use ramucirumab RECIST regorafenib Researchers Retreatment sorafenib Studies Targeted cancer therapy Treatment Failure Treatment Outcome Tumors
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