Spirograterpene A, a Tetracyclic Spiro-Diterpene with a Fused 5/5/5/5 Ring System from the Deep-Sea-Derived Fungus Penicillium granulatum MCCC 3A00475
A novel spiro-tetracyclic diterpene, spirograterpene A (1), was isolated from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475, together with two biosynthetically related cyclopianes, conidiogenone I (2) and conidiogenone C (3). The relative configuration of 1 was elucidated by extens...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2017-07, Vol.80 (7), p.2174-2177 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | Niu, Siwen Fan, Zuo-Wang Xie, Chun-Lan Liu, Qingmei Luo, Zhu-Hua Liu, Guangming Yang, Xian-Wen |
| description | A novel spiro-tetracyclic diterpene, spirograterpene A (1), was isolated from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475, together with two biosynthetically related cyclopianes, conidiogenone I (2) and conidiogenone C (3). The relative configuration of 1 was elucidated by extensive spectroscopic analyses, and the absolute structure was established by the modified Mosher’s method. Compound 1 is the second example of a diterpene featuring a 5/5/5/5 spirocyclic carbon skeleton. It showed modest antiallergic activity. |
| doi_str_mv | 10.1021/acs.jnatprod.7b00475 |
| format | Article |
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Nat. Prod</addtitle><date>2017-07-28</date><risdate>2017</risdate><volume>80</volume><issue>7</issue><spage>2174</spage><epage>2177</epage><pages>2174-2177</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><abstract>A novel spiro-tetracyclic diterpene, spirograterpene A (1), was isolated from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475, together with two biosynthetically related cyclopianes, conidiogenone I (2) and conidiogenone C (3). The relative configuration of 1 was elucidated by extensive spectroscopic analyses, and the absolute structure was established by the modified Mosher’s method. Compound 1 is the second example of a diterpene featuring a 5/5/5/5 spirocyclic carbon skeleton. 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| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2017-07, Vol.80 (7), p.2174-2177 |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Anti-Allergic Agents - chemistry Anti-Allergic Agents - isolation & purification Anti-Allergic Agents - pharmacology Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Marine Biology Molecular Structure Penicillium - chemistry Spiro Compounds |
| title | Spirograterpene A, a Tetracyclic Spiro-Diterpene with a Fused 5/5/5/5 Ring System from the Deep-Sea-Derived Fungus Penicillium granulatum MCCC 3A00475 |
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