Perinatal protein deprivation facilitates morphine cross-sensitization to cocaine and enhances ΔFosB expression in adult rats

•Early malnutrition may increase vulnerability to drug abuse in adult animals.•D-rats showed greater responsiveness to rewarding effects of cocaine.•D-rats elicited morphine cross-sensitization to the rewarding effects of cocaine.•D-rats significantly increased ΔFosB levels in the brain reward netwo...

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Veröffentlicht in:	Behavioural brain research 2017-08, Vol.333, p.203-210
Hauptverfasser:	Perondi, María Cecilia, Gutiérrez, María Cecilia, Valdomero, Analía, Cuadra, Gabriel Ricardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - administration & dosage Analysis of Variance Animals Cocaine Cocaine - pharmacology Conditioned place preference Conditioning, Operant Cross-sensitization Dopamine Uptake Inhibitors - pharmacology Dose-Response Relationship, Drug Drug Administration Schedule Drug Interactions Female Gene Expression Regulation - drug effects Male Morphine Morphine - administration & dosage Perinatal undernutrition Pregnancy Prenatal Nutritional Physiological Phenomena - physiology Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Wistar Reward ΔFosB expression
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