TRPML1: The Ca(2+)retaker of the lysosome

[Display omitted] •Release of Ca2+ from the lysosome is emerging as an important signalling mechanism to modulate autophagy and lysosomal biogenesis.•The lysosomal non selective cation channel TRPML1 plays a major role in such signaling, being involved in vesicular trafficking, lysosomal exocytosis...

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Veröffentlicht in:	Cell calcium (Edinburgh) 2018-01, Vol.69, p.112-121
Hauptverfasser:	Di Paola, Simone, Scotto-Rosato, Anna, Medina, Diego Luis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Calcium - metabolism Humans LSDs Lysosomal calcium Lysosomal function Lysosomes - metabolism Molecular Targeted Therapy Mucolipidoses - metabolism Mucolipidosis type IV TRPM Cation Channels - metabolism TRPMLs
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